From GWAS to functional studies: Tackling the complex nature of brain disorders

Deliverables

Open Research Data Pilot (1)

Data Management Plan

After 6 months the initial data management plan will be delivered and updated during the lifespan of the project.

Publications

Peer reviewed articles (7)

An integrated framework for local genetic correlation analysis

Author(s): Josefin Werme, Sophie van der Sluis, Danielle Posthuma, Cristiaan de Leeuw
Published in: Nature Genetics, March 14, 2022, 2022, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1101/2020.12.31.424652

Statistical testing in transcriptomic-neuroimaging studies: A how-to and evaluation of methods assessing spatial and gene specificity

Author(s): Yongbin Wei, Siemon C. de Lange, Rory Pijnenburg, Lianne H. Scholtens, Dirk Jan Ardesch, Kyoko Watanabe, Danielle Posthuma, Martijn P. van den Heuvel
Published in: Human Brain Mapping, Feb 15 2022, 2021, Page(s) 885-901, ISSN 1097-0193
Publisher: Wiley Online Library
DOI: 10.1002/hbm.25711

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Author(s): Philip R. Jansen, Mats Nagel, Kyoko Watanabe, Yongbin Wei, Jeanne E. Savage, Christiaan A. de Leeuw, Martijn P. van den Heuvel, Sophie van der Sluis & Danielle Posthuma
Published in: Nature Communications, November 5, 2020, 2020, Page(s) Article Number: 5606, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19378-5

Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal

Author(s): Emil Uffelmann, Danielle Posthuma
Published in: Biological Psychiatry, 89/1, 2021, Page(s) 41-53, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2020.05.022

Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Author(s): Josefin Werme, Sophie van der Sluis, Danielle Posthuma & Christiaan A. de Leeuw
Published in: Translational Psychiatry, March 22, 2021, 2021, Page(s) Article number: 180, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-021-01334-6

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Author(s): Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Dominic Holland, Arvid Rongve, Sigrid Børte, Bendik S. Winsvold, Ole Kristian Drange, Amy E. Martinsen, Anne Heidi Skogholt, Cristen Willer, Geir Bråthen, Ingunn Bosnes, Jonas Bille Nielsen, Lars G. Fritsche, Laurent F. Thomas, Linda M. Pedersen, Maiken E. Gabrielsen, Marianne Bakke Johnsen, Tore Wergeland
Published in: Nature Genetics, September 7, 2021, 2021, Page(s) 1276–1282, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00977-x

Genome-wide association studies

Author(s): Emil Uffelmann, Qin Qin Huang, Nchangwi Syntia Munung, Jantina de Vries, Yukinori Okada, Alicia R. Martin, Hilary C. Martin, Tuuli Lappalainen & Danielle Posthuma
Published in: Nature Reviews Methods Primers, August 29, 2021, 2021, Page(s) Article number: 59, ISSN 2662-8449
Publisher: Nature portfolio
DOI: 10.1038/s43586-021-00056-9

Other (4)

Genome-wide association study of cerebellar volume

Author(s): E.P. Tissink, S.C. de Lange, J.E. Savage, D.P. Wightman, K.M. Kelly, M. Nagel, M.P. van den Heuvel, D. Posthuma
Published in: bioRxiv, November 4, 2021, 2021
Publisher: bioRxiv
DOI: 10.1101/2021.11.04.467250

Reconsidering the validity of transcriptome-wide association studies

Author(s): Christiaan de Leeuw, Josefin Werme, Jeanne Savage, Wouter Peyrot, Danielle Posthuma
Published in: BioRxiv, August 15, 2021, 2021
Publisher: BioRxiv
DOI: 10.1101/2021.08.15.456414

Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer’s Disease

Author(s): Douglas P Wightman, Jeanne E Savage, Christiaan A de Leeuw, Iris E Jansen, Danielle Posthuma
Published in: medRxiv, October 18, 2021, 2021
Publisher: medRxiv
DOI: 10.1101/2021.10.17.21265070

Genome-wide meta-analysis of insomnia in over 2.3 million individuals implicates involvement of specific biological pathways through gene-prioritization

Author(s): Kyoko Watanabe, Philip R. Jansen, Jeanne E. Savage, Priyanka Nandakumar, Xin Wang, 23andMe Research Team, David A. Hinds, Joel Gelernter, Daniel F. Levey, Renato Polimanti, Murray B. Stein, Eus J.W. Van Someren, August B. Smit, Danielle Posthuma
Published in: medRxiv, December 7, 2020, 2020
Publisher: bioRxiv
DOI: 10.1101/2020.12.07.20245209