From GWAS to functional studies: Tackling the complex nature of brain disorders

Resultado final

After 6 months the initial data management plan will be delivered and updated during the lifespan of the project.

Publicaciones

An integrated framework for local genetic correlation analysis

Autores: Josefin Werme, Sophie van der Sluis, Danielle Posthuma, Christiaan de Leeuw
Publicado en: Nature Genetics, Edición March 14, 2022, 2022, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1101/2020.12.31.424652

Statistical testing in transcriptomic-neuroimaging studies: A how-to and evaluation of methods assessing spatial and gene specificity

Autores: Yongbin Wei, Siemon C. de Lange, Rory Pijnenburg, Lianne H. Scholtens, Dirk Jan Ardesch, Kyoko Watanabe, Danielle Posthuma, Martijn P. van den Heuvel
Publicado en: Human Brain Mapping, Edición Feb 15 2022, 2021, Página(s) 885-901, ISSN 1097-0193
Editor: Wiley Online Library
DOI: 10.1002/hbm.25711

Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health

Autores: Elleke Tissink; Siemon C. de Lange; Jeanne E. Savage; Douglas P. Wightman; Christiaan A. de Leeuw; Kristen M. Kelly; Mats Nagel; Martijn P. van den Heuvel; Danielle Posthuma
Publicado en: Communications Biology, Edición 5(710), 2022, ISSN 2399-3642
Editor: Springer Nature
DOI: 10.1038/s42003-022-03672-7

Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers

Autores: Jansen, Iris; van der Lee, Sven J; Bellenguez, Céline; Ramakers, Inez; Rodriguez-Rodriguez, Eloy; Rujescu, Dan; Saltvedt, Ingvild; Sanchez-Juan, Pascual; Scheltens, Philip; Scherbaum, Norbert; Schmid, Matthias; Schneider, Anja; Selbæk, Geir; Kleineidam, Luca; Selnes, Per; Shadrin, Alexey; Skoog, Ingmar; Soininen, Hilkka; Tárraga, Lluís; Teipel, Stefan; group, GR@ACE study; Tijms, Betty; Tsolak
Publicado en: Acta Neuropathologica, Edición Volume 144, 2022, Página(s) 821-842, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-022-02454-z

The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks

Autores: Elleke Tissink; Josefin Werme; Siemon C. de Lange; Jeanne E. Savage; Yongbin Wei; Christiaan A. de Leeuw; Mats Nagel; Danielle Posthuma; Martijn P. van den Heuvel
Publicado en: eNeuro, Edición 10(4), 2023, ISSN 2373-2822
Editor: Society for Neuroscience
DOI: 10.1523/eneuro.0242-22.2023

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Autores: Philip R. Jansen, Mats Nagel, Kyoko Watanabe, Yongbin Wei, Jeanne E. Savage, Christiaan A. de Leeuw, Martijn P. van den Heuvel, Sophie van der Sluis & Danielle Posthuma
Publicado en: Nature Communications, Edición November 5, 2020, 2020, Página(s) Article Number: 5606, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19378-5

Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

Autores: Emil Uffelmann, Danielle Posthuma, Wouter J. Peyrot
Publicado en: Scientific Reports - Nature, Edición 4219 (2023), 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-29428-9

Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways

Autores: Kyoko Watanabe; Philip R. Jansen; Jeanne E. Savage; Priyanka Nandakumar; Xin Wang; Michelle Agee; Stella Aslibekyan; Adam Auton; Robert K. Bell; Katarzyna Bryc; Sarah K. Clark; Sarah L. Elson; Kipper Fletez-Brant; Pierre Fontanillas; Nicholas A. Furlotte; Pooja M. Gandhi; Karl Heilbron; Barry Hicks; Karen E. Huber; Ethan M. Jewett; Yunxuan Jiang; Aaron Kleinman; Keng-Han Lin; Nadia K. Litterman; J
Publicado en: Nature Genetics, Edición 54(8), 2022, Página(s) 1125-1132, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-022-01124-w

The genetic overlap between Alzheimer’s disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson’s disease

Autores: Douglas P. Wightman, Jeanne E. Savage, Elleke Tissink, Cato Romero, Iris E. Jansen, Danielle Posthuma
Publicado en: Neurobiology of Aging, Edición Volume 127, 2023, Página(s) 99-112, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2023.03.004

Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal

Autores: Emil Uffelmann, Danielle Posthuma
Publicado en: Biological Psychiatry, Edición 89/1, 2021, Página(s) 41-53, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2020.05.022

Genome-wide gene-environment interactions in neuroticism: an exploratory study across 25 environments

Autores: Josefin Werme, Sophie van der Sluis, Danielle Posthuma & Christiaan A. de Leeuw
Publicado en: Translational Psychiatry, Edición March 22, 2021, 2021, Página(s) Article number: 180, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-021-01334-6

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Autores: Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Dominic Holland, Arvid Rongve, Sigrid Børte, Bendik S. Winsvold, Ole Kristian Drange, Amy E. Martinsen, Anne Heidi Skogholt, Cristen Willer, Geir Bråthen, Ingunn Bosnes, Jonas Bille Nielsen, Lars G. Fritsche, Laurent F. Thomas, Linda M. Pedersen, Maiken E. Gabrielsen, Marianne Bakke Johnsen, Tore Wergeland
Publicado en: Nature Genetics, Edición September 7, 2021, 2021, Página(s) 1276–1282, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-021-00977-x

Exploring the genetic overlap between twelve psychiatric disorders

Autores: ato Romero, Josefin Werme, Philip R. Jansen, Joel Gelernter, Murray B. Stein, Daniel Levey, Renato Polimanti, Christiaan de Leeuw, Danielle Posthuma, Mats Nagel, Sophie van der Sluis
Publicado en: Nature Genetics, Edición 54, 2022, Página(s) 1795-1802, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-022-01245-2

On the interpretation of transcriptome-wide association studies

Autores: Christiaan de Leeuw, Josefin Werme, Jeanne E. Savage, Wouter J. Peyrot, Danielle Posthuma
Publicado en: PLOS Genetics, Edición 19(9): e101092, 2023, ISSN 1553-7390
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1010921

Genome-wide association studies

Autores: Emil Uffelmann, Qin Qin Huang, Nchangwi Syntia Munung, Jantina de Vries, Yukinori Okada, Alicia R. Martin, Hilary C. Martin, Tuuli Lappalainen & Danielle Posthuma
Publicado en: Nature Reviews Methods Primers, Edición August 29, 2021, 2021, Página(s) Article number: 59, ISSN 2662-8449
Editor: Nature portfolio
DOI: 10.1038/s43586-021-00056-9

Demystifying non-coding GWAS variants: an overview of computational tools and methods

Autores: Marijn Schipper, Danielle Posthuma
Publicado en: Human Molecular Genetics, Edición Volume 31, Edición R1, 2022, Página(s) R73-R83, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddac198

Mapping the genetic evolutionary timeline of human neural and cognitive traits

Autores: Ilan Libedinsky; Yongbin Wei; Christiaan de Leeuw; James K. Rilling; Danielle Posthuma; Martijn P. van den Heuvel
Publicado en: bioRxiv, Edición Sep 28, 2023, 2023
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.05.525539

Genome-wide association study of cerebellar volume

Autores: E.P. Tissink, S.C. de Lange, J.E. Savage, D.P. Wightman, K.M. Kelly, M. Nagel, M.P. van den Heuvel, D. Posthuma
Publicado en: bioRxiv, Edición November 4, 2021, 2021
Editor: bioRxiv
DOI: 10.1101/2021.11.04.467250

Patient iPSC-derived astrocytes with high polygenic risk for schizophrenia reveals a role for mitochondrial glutamate carrier SLC25A18

Autores: Stephanie Beekhuis-Hoekstra; Karen Laupman; Yongbin Wei; Kyoko Watanabe; Paulien Cornelissen-Steijger; Patrick Sullivan; Danielle Posthuma; Vivi Heine
Publicado en: Research Square, Edición 15 JUl, 2022, 2022, ISSN 2693-5015
Editor: Research Square
DOI: 10.21203/rs.3.rs-1811182/v1

Reconsidering the validity of transcriptome-wide association studies

Autores: Christiaan de Leeuw, Josefin Werme, Jeanne Savage, Wouter Peyrot, Danielle Posthuma
Publicado en: BioRxiv, Edición August 15, 2021, 2021
Editor: BioRxiv
DOI: 10.1101/2021.08.15.456414

Estimating Disorder Probability Based on Polygenic Prediction Using the BPC Approach

Autores: Emil Uffelmann, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Alkes L. Price, Danielle Posthuma, Wouter J. Peyrot
Publicado en: medRxiv, Edición January 14, 2024, 2024
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.01.12.24301157

Local Genetic Sex Differences in Quantitative Traits

Autores: Emil Uffelmann, Christiaan de Leeuw, Danielle Posthuma
Publicado en: medRxiv, Edición May 4, 2023, 2023
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.04.539410

Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer’s Disease

Autores: Douglas P Wightman, Jeanne E Savage, Christiaan A de Leeuw, Iris E Jansen, Danielle Posthuma
Publicado en: medRxiv, Edición October 18, 2021, 2021
Editor: medRxiv
DOI: 10.1101/2021.10.17.21265070

Genome-wide meta-analysis of insomnia in over 2.3 million individuals implicates involvement of specific biological pathways through gene-prioritization

Autores: Kyoko Watanabe, Philip R. Jansen, Jeanne E. Savage, Priyanka Nandakumar, Xin Wang, 23andMe Research Team, David A. Hinds, Joel Gelernter, Daniel F. Levey, Renato Polimanti, Murray B. Stein, Eus J.W. Van Someren, August B. Smit, Danielle Posthuma
Publicado en: medRxiv, Edición December 7, 2020, 2020
Editor: bioRxiv
DOI: 10.1101/2020.12.07.20245209

Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Autores: E.P. Tissink; A.A. Shadrin; D. van der Meer; N. Parker; G. Hindley; D. Roelfs; O. Frei; C.C. Fan; M. Nagel; T. Nærland; M. Budisteanu; S. Djurovic; L. T. Westlye; M.P. van den Heuvel; D. Posthuma; T. Kaufmann; A.M. Dale; O.A. Andreassen
Publicado en: bioRxiv, Edición 20 December, 2022, 2022
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.12.20.521181

Local genetic correlation analysis links depression with molecular and brain imaging endophenotypes

Autores: J. Werme; E.P. Tissink; S.C. de Lange; M.P. van den Heuvel; D. Posthuma; C.A. de Leeuw
Publicado en: medRxiv, Edición March 3, 2023, 2023
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.03.01.23286613

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