Project description
Miniature soft robots could soon be reaching the unreachable in the human body
In the 1966 film Fantastic Voyage, a submarine and its crew are shrunken and injected into the bloodstream of a scientist to repair damage to his brain. More than 50 years later, SoMMoR is bringing the concept to life, this time with miniature wireless soft robots. Technology has advanced tremendously over the years. It is now possible to make miniature wireless machines down to micron scale. Smart, soft, magnetic and multifunctional micro/nanomaterials enable loading and targeted controlled release of therapeutics. SoMMoR is taking the next step, integrating soft microrobotic smart materials, multimodal robot locomotion and control, medical functionality, and human safety for solving challenging medical problems in a minimally invasive manner. The project plans to achieve the preliminary in vivo testing of new soft milli/microscale robot designs in small animal models. Potential diagnostic and therapeutic applications are virtually limitless as these tiny robots can reach unprecedented and risky regions inside the human body with minimal invasion.
Objective
Untethered mobile milli/microrobots would have a radical impact in medicine. Such untethered tiny machines could access smaller regions inside the body, remain inside the body for long durations as semi-implantable medical devices, and enable diagnostic and therapeutic medical operations in hard or currently not possible to reach regions inside the body with minimal or no invasion. While many groups have been working intensely on creating such new machines for potential medical applications, there are still many significant challenges that must be addressed: 3D design, fabrication and materials of safe and multi-functional medical mobile robots down to tens of micrometer size scale, robust locomotion of these robots inside the complex human body, precise navigation control under medical imaging modalities, integrating diagnostic and therapeutic medical functions to them, and demonstrating their clinically relevant medical applications in in vivo animal models. To address these challenges, we propose to create new soft-bodied mobile milli/microrobots with medical functions and sizes down to tens of micron scale to address the above challenges of untethered miniature robots. Such shape-programmable tiny soft machines will be created from biocompatible magnetic soft composite materials, will be actuated by external magnetic fields or gradients, will have multimodal robust locomotion capability, integrated medical functions and safe interactions inside the human body, will be tracked by real-time medical imaging systems, and will be demonstrated in clinically relevant active local cargo (e.g. drug) delivery, remote heating-based coagulation and hyperthermia, and deliberate vessel and tube clogging applications. Research tasks of the robot design, fabrication and materials, robot actuation, locomotion and control, robot medical functions, and robot characterization and in vitro, ex vivo and in vivo testing will be performed to achieve our research objectives.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-ADG - Advanced Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2018-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
34450 Istanbul
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.