Descripción del proyecto
Mejora de la supervisión y tratamiento de la neurodegeneración
Las enfermedades neurodegenerativas, como la enfermedad de Alzheimer y la enfermedad de Parkinson, afectan a millones de personas en todo el mundo. No tienen cura y conducen progresivamente a la pérdida de estructura o función de las neuronas. La supervisión y la regulación precisas de la función neuronal, tanto del sistema nervioso central como del periférico, son procedimientos muy complejos pero prometedores para el diagnóstico y tratamiento rápidos de estas enfermedades. El proyecto e-NeuroPharma, financiado con fondos europeos, respalda el uso de materiales y dispositivos electrónicos orgánicos como tecnologías facilitadoras esenciales para traducir señales electrónicas en entidades de señalización endógenas del sistema nervioso. Su objetivo principal es desarrollar materiales que puedan atravesar la barrera hematoencefálica y puedan registrar y regular varios parámetros relevantes en las enfermedades neurodegenerativas.
Objetivo
As the population ages, neurodegenerative diseases (ND) will have a devastating impact on individuals and society. Despite enormous research efforts there is still no cure for these diseases, only care! The origin of ND is hugely complex, spanning from the molecular level to systemic processes, causing malfunctioning of signalling in the central nervous system (CNS). This signalling includes the coupled processing of biochemical and electrical signals, however current approaches for symptomatic- and disease modifying treatments are all based on biochemical approaches, alone.
Organic bioelectronics has arisen as a promising technology providing signal translation, as sensors and modulators, across the biology-technology interface; especially, it has proven unique in neuronal applications. There is great opportunity with organic bioelectronics since it can complement biochemical pharmacology to enable a twinned electric-biochemical therapy for ND and neurological disorders. However, this technology is traditionally manufactured on stand-alone substrates. Even though organic bioelectronics has been manufactured on flexible and soft carriers in the past, current technology consume space and volume, that when applied to CNS, rule out close proximity and amalgamation between the bioelectronics technology and CNS components – features that are needed in order to reach high therapeutic efficacy.
e-NeuroPharma includes development of innovative organic bioelectronics, that can be in-vivo-manufactured within the brain. The overall aim is to evaluate and develop electrodes, delivery devices and sensors that enable a twinned biochemical-electric therapy approach to combat ND and other neurological disorders. e-NeuroPharma will focus on the development of materials that can cross the blood-brain-barrier, that self-organize and -polymerize along CNS components, and that record and regulate relevant electrical, electrochemical and physical parameters relevant to ND and disorders
Ámbito científico
Palabras clave
Programa(s)
Régimen de financiación
ERC-ADG - Advanced GrantInstitución de acogida
581 83 Linkoping
Suecia