Projektbeschreibung
Fortschritte bei der Überwachung und Behandlung von Neurodegeneration
Neurodegenerative Erkrankungen wie die Alzheimer- und die Parkinson-Krankheit betreffen weltweit Millionen Menschen. Sie sind unheilbar und bewirken den fortschreitenden Verlust der Struktur oder Funktion von Neuronen. Die neuronale Funktion sowohl im peripheren als auch im zentralen Nervensystem genau zu überwachen und zu regulieren, stellt eine große Herausforderung dar, lässt jedoch auch auf eine schnelle Diagnose und Behandlung dieser Krankheiten hoffen. Das EU-finanzierte Projekt e-NeuroPharma unterstützt die Einführung organischer elektronischer Materialien und Bauelemente als eine Schlüsseltechnologie für die Weitergabe elektronischer Signale in die endogenen Signaleinheiten des Nervensystems. Übergeordnetes Ziel ist die Entwicklung von Materialien, welche die Blut-Hirn-Schranke überwinden und verschiedene für neurodegenerative Erkrankungen relevante Parameter aufzeichnen und regulieren können.
Ziel
As the population ages, neurodegenerative diseases (ND) will have a devastating impact on individuals and society. Despite enormous research efforts there is still no cure for these diseases, only care! The origin of ND is hugely complex, spanning from the molecular level to systemic processes, causing malfunctioning of signalling in the central nervous system (CNS). This signalling includes the coupled processing of biochemical and electrical signals, however current approaches for symptomatic- and disease modifying treatments are all based on biochemical approaches, alone.
Organic bioelectronics has arisen as a promising technology providing signal translation, as sensors and modulators, across the biology-technology interface; especially, it has proven unique in neuronal applications. There is great opportunity with organic bioelectronics since it can complement biochemical pharmacology to enable a twinned electric-biochemical therapy for ND and neurological disorders. However, this technology is traditionally manufactured on stand-alone substrates. Even though organic bioelectronics has been manufactured on flexible and soft carriers in the past, current technology consume space and volume, that when applied to CNS, rule out close proximity and amalgamation between the bioelectronics technology and CNS components – features that are needed in order to reach high therapeutic efficacy.
e-NeuroPharma includes development of innovative organic bioelectronics, that can be in-vivo-manufactured within the brain. The overall aim is to evaluate and develop electrodes, delivery devices and sensors that enable a twinned biochemical-electric therapy approach to combat ND and other neurological disorders. e-NeuroPharma will focus on the development of materials that can cross the blood-brain-barrier, that self-organize and -polymerize along CNS components, and that record and regulate relevant electrical, electrochemical and physical parameters relevant to ND and disorders
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Finanzierungsplan
ERC-ADG - Advanced GrantGastgebende Einrichtung
581 83 Linkoping
Schweden