Description du projet
Faire progresser la surveillance et le traitement de la neurodégénérescence
Les maladies neurodégénératives telles que la maladie d’Alzheimer et la maladie de Parkinson touchent des millions de personnes dans le monde. Elles sont incurables et entraînent progressivement la perte de la structure ou de la fonction des neurones. La surveillance et la régulation précises de la fonction neuronale, tant dans le système nerveux périphérique que dans le système nerveux central, constituent des défis majeurs mais sont porteuses d’espoir pour un diagnostic et un traitement rapides de ces maladies. Le projet e-NeuroPharma, financé par l’UE, soutient la mise en œuvre de matériaux et de dispositifs électroniques organiques en tant que technologie clé permettant de traduire les signaux électroniques en entités de signalisation endogènes du système nerveux. L’objectif global est de développer des matériaux capables de traverser la barrière hémato-encéphalique et d’enregistrer et de réguler divers paramètres pertinents pour les maladies neurodégénératives.
Objectif
As the population ages, neurodegenerative diseases (ND) will have a devastating impact on individuals and society. Despite enormous research efforts there is still no cure for these diseases, only care! The origin of ND is hugely complex, spanning from the molecular level to systemic processes, causing malfunctioning of signalling in the central nervous system (CNS). This signalling includes the coupled processing of biochemical and electrical signals, however current approaches for symptomatic- and disease modifying treatments are all based on biochemical approaches, alone.
Organic bioelectronics has arisen as a promising technology providing signal translation, as sensors and modulators, across the biology-technology interface; especially, it has proven unique in neuronal applications. There is great opportunity with organic bioelectronics since it can complement biochemical pharmacology to enable a twinned electric-biochemical therapy for ND and neurological disorders. However, this technology is traditionally manufactured on stand-alone substrates. Even though organic bioelectronics has been manufactured on flexible and soft carriers in the past, current technology consume space and volume, that when applied to CNS, rule out close proximity and amalgamation between the bioelectronics technology and CNS components – features that are needed in order to reach high therapeutic efficacy.
e-NeuroPharma includes development of innovative organic bioelectronics, that can be in-vivo-manufactured within the brain. The overall aim is to evaluate and develop electrodes, delivery devices and sensors that enable a twinned biochemical-electric therapy approach to combat ND and other neurological disorders. e-NeuroPharma will focus on the development of materials that can cross the blood-brain-barrier, that self-organize and -polymerize along CNS components, and that record and regulate relevant electrical, electrochemical and physical parameters relevant to ND and disorders
Champ scientifique
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Régime de financement
ERC-ADG - Advanced GrantInstitution d’accueil
581 83 Linkoping
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