Descripción del proyecto
Una comprensión más profunda de la alteración del cronotipo
Cada persona posee un cronotipo único, una pauta individual de sueño. El ritmo circadiano natural regula el sueño y los niveles de actividad. Lamentablemente, el desajuste circadiano se ha convertido en un fenómeno habitual, principalmente debido a factores medioambientales que pueden alterar considerablemente la cronología y la expresión del sueño y la vigilia. El proyecto CHRONO, financiado con fondos europeos, revisará las causas y consecuencias de la alteración del cronotipo provocadas por el uso generalizado de dispositivos electrónicos, la luz artificial y las presiones relacionadas con el trabajo en un entorno económico activo las veinticuatro horas del día. Intentará explicar el papel de la biología, la sociedad y el medio natural y su interacción a la hora de predecir y comprender la resiliencia a la alteración del cronotipo. CHRONO desarrollará un modelo teórico interdisciplinario multifactorial. Además, mediante la colaboración masiva generará un conjunto de datos sociogenómicos con medidas novedosas.
Objetivo
The widespread use of electronic devices, artificial light and rise of the 24-hour economy means that more individuals experience disruption of their chronotype, which is the natural circadian rhythm that regulates sleep and activity levels. The natural and medical sciences focus on the natural environment (e.g. light exposure), genetics, biology and health consequences, whereas the social sciences have largely explored the socio-environment (e.g. working regulations) and psychological and familial consequences of nonstandard work schedules. For the first time CHRONO bridges these disparate disciplines to ask: What is the role of biology, the natural and socio-environment and their interaction on predicting and understanding resilience to chronotype disruption and how does this in turn impact an individual’s health (sleep, cancer, obesity, digestive problems) and family (partnership, children) outcomes? I propose to: (1) develop a multifactor interdisciplinary theoretical model; (2) disrupt data collection by crowdsourcing a sociogenomic dataset with novel measures; (3) discover and validate with informed machine learning innovative measures of chronotype (molecular genetic, accelerometer, microbiome, patient-record, self-reported) and the natural and socio-environment; (4) ask fundamentally new substantive questions to determine how chronotype disruption influences health and family outcomes and, via Biology x Environment interaction (BxE), whether this is moderated by the natural or socio-environment; and, (5) develop new statistical models and methods to cope with contentious issues, answer longitudinal questions and engage in novel quasi-experiments (e.g. policy and life course changes) to transcend description to identify endogenous factors and causal mechanisms. Interdisciplinary in the truest sense, CHRONO will overturn long-held substantive findings of the causes and consequences of chronotype disruption.
Ámbito científico
- natural sciencesbiological sciencesgenetics
- natural sciencesmathematicsapplied mathematicsstatistics and probability
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
- natural sciencesbiological sciencesmicrobiology
- medical and health scienceshealth sciencesnutritionobesity
Palabras clave
Programa(s)
Régimen de financiación
ERC-ADG - Advanced GrantInstitución de acogida
OX1 2JD Oxford
Reino Unido