Description du projet
Une meilleure compréhension de la perturbation du chronotype
Chaque personne possède un chronotype unique, un rythme de sommeil individuel. Il s’agit du rythme circadien naturel qui régule les niveaux d’activité et de sommeil. Malheureusement, le désalignement circadien est devenu un phénomène courant, principalement en raison de facteurs environnementaux pouvant modifier considérablement le temps et l’expression du sommeil et de l’éveil. Le projet CHRONO, financé par l’UE, examinera les causes et les conséquences de la perturbation du chronotype provoquée par l’utilisation généralisée de dispositifs électroniques, la lumière artificielle et les pressions liées au travail dans une économie opérationnelle 24 heures sur 24. Il cherchera à expliquer le rôle de la biologie, de la société, de l’environnement naturel et leurs interactions sur la prédiction et la compréhension de la résilience à la perturbation du chronotype. CHRONO élaborera un modèle théorique interdisciplinaire et multifactoriel. En outre, il produira de manière participative un ensemble de données sociogénomiques à l’aide de mesures innovantes.
Objectif
The widespread use of electronic devices, artificial light and rise of the 24-hour economy means that more individuals experience disruption of their chronotype, which is the natural circadian rhythm that regulates sleep and activity levels. The natural and medical sciences focus on the natural environment (e.g. light exposure), genetics, biology and health consequences, whereas the social sciences have largely explored the socio-environment (e.g. working regulations) and psychological and familial consequences of nonstandard work schedules. For the first time CHRONO bridges these disparate disciplines to ask: What is the role of biology, the natural and socio-environment and their interaction on predicting and understanding resilience to chronotype disruption and how does this in turn impact an individual’s health (sleep, cancer, obesity, digestive problems) and family (partnership, children) outcomes? I propose to: (1) develop a multifactor interdisciplinary theoretical model; (2) disrupt data collection by crowdsourcing a sociogenomic dataset with novel measures; (3) discover and validate with informed machine learning innovative measures of chronotype (molecular genetic, accelerometer, microbiome, patient-record, self-reported) and the natural and socio-environment; (4) ask fundamentally new substantive questions to determine how chronotype disruption influences health and family outcomes and, via Biology x Environment interaction (BxE), whether this is moderated by the natural or socio-environment; and, (5) develop new statistical models and methods to cope with contentious issues, answer longitudinal questions and engage in novel quasi-experiments (e.g. policy and life course changes) to transcend description to identify endogenous factors and causal mechanisms. Interdisciplinary in the truest sense, CHRONO will overturn long-held substantive findings of the causes and consequences of chronotype disruption.
Champ scientifique
- natural sciencesbiological sciencesgenetics
- natural sciencesmathematicsapplied mathematicsstatistics and probability
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
- natural sciencesbiological sciencesmicrobiology
- medical and health scienceshealth sciencesnutritionobesity
Mots‑clés
Programme(s)
Thème(s)
Régime de financement
ERC-ADG - Advanced GrantInstitution d’accueil
OX1 2JD Oxford
Royaume-Uni