Mitochondrial Cristae Biogenesis

Informazioni relative al progetto

MitoCRISTAE

ID dell’accordo di sovvenzione: 835102

DOI

10.3030/835102

Progetto chiuso

Data della firma CE 12 Giugno 2019

Data di avvio 1 Ottobre 2019

Data di completamento 30 Settembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 286 248,00

Contributo UE

€ 2 286 248,00

Coordinato da

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (29)

Light microscopy of mitochondria at the nanoscale

Autori: Stefan Jakobs, Till Stephan, Peter Ilgen, Christian Brüser
Pubblicato in: Annual review of biophysics, Numero 49, 2020, Pagina/e 289-308, ISSN 1936-122X
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-121219-081550

Structural insights into crista junction formation by the Mic60-Mic19 complex

Autori: Tobias Bock-Bierbaum, Kathrin Funck, Florian Wollweber, Elisa Lisicki, Karina von der Malsburg, Alexander von der Malsburg, Janina Laborenz, Jeffrey K. Noel, Manuel Hessenberger, Sibylle Jungbluth, Carola Bernert, Séverine Kunz, Dietmar Riedel, Hauke Lilie, Stefan Jakobs, Martin van der Laan, Oliver Daumke
Pubblicato in: Science Advances, Numero 8/35, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.abo4946

MINSTED fluorescence localization and nanoscopy

Autori: Michael Weber, Marcel Leutenegger, Stefan Stoldt, Stefan Jakobs, Tiberiu S. Mihaila, Alexey N. Butkevich, Stefan W. Hell
Pubblicato in: Nature Photonics, Numero 15/5, 2021, Pagina/e 361-366, ISSN 1749-4885
Editore: Nature Pub. Group
DOI: 10.1038/s41566-021-00774-2

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation.

Autori: Stephan T, Brüser C, Deckers M, Steyer AM, Balzarotti F, Barbot M, Behr TS, Heim G, Hübner W, Ilgen P, Lange F, Pacheu-Grau D, Pape JK, Stoldt S, Huser T, Hell SW, Möbius W, Rehling P, Riedel D, Jakobs S
Pubblicato in: The EMBO Journal, Numero 39/14, 2020, ISSN 1460-2075
Editore: EMBO journal
DOI: 10.15252/embj.2019104105

An aldehyde-crosslinking mitochondrial probe for STED imaging in fixed cells

Autori: Jingting Chen, Till Stephan, Felix Gaedke, Tianyan Liu, Yiyan Li, Astrid Schauss, Peng Chen, Veronika Wulff, Stefan Jakobs, Christian Jüngst, Zhixing Chen
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 121, 2025, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2317703121

Monitoring mitochondrial translation in living cells.

Autori: Roya Yousefi Eugenio F Fornasiero Lukas Cyganek Julio Montoya Stefan Jakobs Silvio O Rizzoli Peter Rehling David Pacheu‐Grau
Pubblicato in: EMBO Reports, 2021, ISSN 1469-3178
Editore: EMBO Press
DOI: 10.15252/embr.202051635

Drosophila MIC10b can polymerize into cristae-shaping filaments

Autori: Till Stephan Stefan Stoldt Mariam Barbot Travis D Carney Felix Lange Mark Bates Peter Bou Dib Kaushik Inamdar Halyna R Shcherbata Michael Meinecke Dietmar Riedel Sven Dennerlein Peter Rehling Stefan Jakobs
Pubblicato in: Life Science Alliance, 2024, ISSN 2575-1077
Editore: Life Science Alliance LLC
DOI: 10.26508/lsa.202302177

MultiMatch: geometry-informed colocalization in multi-color super-resolution microscopy

Autori: Julia Naas, Giacomo Nies, Housen Li, Stefan Stoldt, Bernhard Schmitzer, Stefan Jakobs, Axel Munk
Pubblicato in: Communications Biology, Numero 7, 2024, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-06772-8

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

Autori: Sabine Poerschke; Sven Dennerlein; Silke Oeljeklaus; Cong Wang; Ricarda Richter-Dennerlein; Johannes Sattmann; Diana Bauermeister; Elisa Hanitsch; Stefan Stoldt; Thomas Langer; Stefan Jakobs; Bettina Warscheid; Peter Rehling
Pubblicato in: eLife, Numero 1, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.68213

Decisive role of mDia-family formins in cell cortex function of highly adherent cells

Autori: Jonas Scholz, Till Stephan, Aina Gallemí Pérez, Agnes Csiszár, Nils Hersch, Lisa S. Fischer, Stefan Brühmann, Sarah Körber, Christof Litschko, Lucija Mijanovic, Thomas Kaufmann, Felix Lange, Ronald Springer, Andreas Pich, Stefan Jakobs, Michelle Peckham, Marco Tarantola, Carsten Grashoff, Rudolf Merkel, Jan Faix
Pubblicato in: Science Advances, Numero 10, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adp5929

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models

Autori: Hafiza Nosheen Saleem, Nadezda Ignatyeva, Christiaan Stuut, Stefan Jakobs, Michael Habeck, Antje Ebert
Pubblicato in: Cells, Numero 13, 2025, Pagina/e 923, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells13110923

Super-resolution microscopy of mitochondrial mRNAs

Autori: Stefan Stoldt, Frederike Maass, Michael Weber, Sven Dennerlein, Peter Ilgen, Jutta Gärtner, Aysenur Canfes, Sarah V. Schweighofer, Daniel C. Jans, Peter Rehling, Stefan Jakobs
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-61577-5

Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins

Autori: Jasmin K. Pape, Till Stephan, Francisco Balzarotti, Rebecca Büchner, Felix Lange, Dietmar Riedel, Stefan Jakobs, Stefan W. Hell
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/34, 2020, Pagina/e 20607-20614, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2009364117

Colocalization for super-resolution microscopy via optimal transport

Autori: Carla Tameling, Stefan Stoldt, Till Stephan, Julia Naas, Stefan Jakobs, Axel Munk
Pubblicato in: Nature Computational Science, 2021, ISSN 2662-8457
Editore: Nature
DOI: 10.1038/s43588-021-00050-x

DNA-PAINT MINFLUX nanoscopy.

Autori: Lynn M. Ostersehlt Daniel C. Jans Anna Wittek Jan Keller-Findeisen Kaushik Inamdar Steffen J. Sahl Stefan W. Hell Stefan Jakobs
Pubblicato in: Nature Methods, 2022, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-022-01577-1

Deep learning enables fast, gentle STED microscopy

Autori: Vahid Ebrahimi Till Stephan Jiah Kim Pablo Carravilla Christian Eggeling Stefan Jakobs Kyu Young Han
Pubblicato in: communications biology, 2023, ISSN 2399-3642
Editore: Springer Nature
DOI: 10.1038/s42003-023-05054-z

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain

Autori: Tianyan Liu; Till Stephan; Peng Chen; Jan Keller-Findeisen; Jingting Chen; Dietmar Riedel; Zhongtian Yang; Stefan Jakobs; Zhixing Chen
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America, Numero 2, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2215799119

In situ architecture of the human prohibitin complex

Autori: Felix Lange, Michael Ratz, Jan-Niklas Dohrke, Maxence Le Vasseur, Dirk Wenzel, Peter Ilgen, Dietmar Riedel, Stefan Jakobs
Pubblicato in: Nature Cell Biology, Numero 27, 2025, Pagina/e 633-640, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-025-01620-1

Silencing mitochondrial gene expression in living cells

Autori: Luis Daniel Cruz-Zaragoza, Drishan Dahal, Mats Koschel, Angela Boshnakovska, Aiturgan Zheenbekova, Mehmet Yilmaz, Marcel Morgenstern, Jan-Niklas Dohrke, Julian Bender, Anusha Valpadashi, Kristine A. Henningfeld, Silke Oeljeklaus, Laura Sophie Kremer, Mirjam Breuer, Oliver Urbach, Sven Dennerlein, Michael Lidschreiber, Stefan Jakobs, Bettina Warscheid, Peter Rehling
Pubblicato in: Science, Numero 389, 2025, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adr3498

The near-infrared bacteriophytochrome-derived fluorescent protein PENELOPE enables RESOLFT superresolution microscopy

Autori: Daniel Stumpf, Nickels Jensen, Cédric Mittelheisser, Jan Keller-Findeisen, Alexey I. Chizhik, Maria Kamper, Timo Diekmann, Florian Habenstein, Isabelle Jansen, Jörg Enderlein, Michel Sliwa, Kaushik Inamdar, Stefan W. Hell, Stefan Jakobs
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2504748122

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase

Autori: Praveenraj Elancheliyan, Klaudia K. Maruszczak, Remigiusz Adam Serwa, Till Stephan, Ahmet Sadik Gulgec, Mayra A. Borrero-Landazabal, Sonia Ngati, Aleksandra Gosk, Stefan Jakobs, Michal Wasilewski, Agnieszka Chacinska
Pubblicato in: Cell Reports, Numero 43, 2025, Pagina/e 115038, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2024.115038

Optimal precision and accuracy in 4Pi-STORM using dynamic spline PSF models

Autori: Mark Bates, Jan Keller-Findeisen, Adrian Przybylski, Andreas Hüper, Till Stephan, Peter Ilgen, Angel R. Cereceda Delgado, Elisa D’Este, Alexander Egner, Stefan Jakobs, Steffen J. Sahl, Stefan W. Hell
Pubblicato in: Nature Methods, Numero 19, 2022, Pagina/e 603-612, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-022-01465-8

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels

Autori: Christian Brüser, Jan Keller-Findeisen, Stefan Jakobs
Pubblicato in: Cell Reports, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.110000

Developmental changes of the mitochondria in the murine anteroventral cochlear nucleus

Autori: Hintze, A.; Lange, F.; Steyer, A.; Anstatt, J.; Möbius, W.; Jakobs, S. ; https://orcid.org/0000-0002-8028-3121; Wichmann, C.
Pubblicato in: iScience, Numero 2, 2024, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2023.108700

Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria

Autori: Sarah V. Schweighofer, Daniel C. Jans, Jan Keller-Findeisen, Anne Folmeg, Peter Ilgen, Mark Bates, Stefan Jakobs
Pubblicato in: Cell Death & Differentiation, Numero 31, 2024, Pagina/e 469-478, ISSN 1350-9047
Editore: Nature Publishing Group
DOI: 10.1038/s41418-024-01273-x

Mitochondrial Protein Abundance Gradients Require the Distribution of Separated Mitochondria.

Autori: Franziska Bollmann; Jan-Niklas Dohrke; Jan-Niklas Dohrke; Christian A. Wurm; Daniel C. Jans; Daniel C. Jans; Stefan Jakobs; Stefan Jakobs; Stefan Jakobs
Pubblicato in: Biology (Basel), Numero 1, 2021, ISSN 2079-7737
Editore: Basel: MDPI AG
DOI: 10.3390/biology10070572

Mitochondrial dysfunction and impaired oxidative stress defense as potential trigger of cerebral X-linked adrenoleukodystrophy

Autori: L.M. Marten, M.S. Lüttgens, B. Berečić, M. Tiburcy, C. Brüser, S. Gupta, S. Jakobs, E. Ammer, A. Ohlenbusch, R. Krätzner, H. Rosewich, J. Gärtner
Pubblicato in: Free Radical Biology and Medicine, Numero 242, 2025, Pagina/e 654-666, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2025.10.289

Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation

Autori: Benedikt S. Saller, Svenja Wöhrle, Larissa Fischer, Clara Dufossez, Isabella L. Ingerl, Susanne Kessler, Maria Mateo-Tortola, Oliver Gorka, Felix Lange, Yurong Cheng, Emilia Neuwirt, Adinarayana Marada, Christoph Koentges, Chiara Urban, Philipp Aktories, Peter Reuther, Sebastian Giese, Susanne Kirschnek, Carolin Mayer, Johannes Pilic, Hugo Falquez-Medina, Aline Oelgeklaus, Veerasikku Gopal Deepag
Pubblicato in: Immunity, Numero 58, 2025, Pagina/e 90-107.e11, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2024.10.012

A data-driven model for mitochondrial inner membrane remodeling as a driving force of organelle shaping

Autori: Noga Preminger, Ben Zucker, Sarah Hassdenteufel, Till Stephan, Stefan Jakobs, Michael M. Kozlov, Maya Schuldiner
Pubblicato in: Journal of Cell Science, Numero 138, 2025, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.263850

Non-peer reviewed articles (9)

MINSTED fluorescence localization and nanoscopy

Autori: Michael Weber, Marcel Leutenegger, Stefan Stoldt, Stefan Jakobs, Tiberiu S. Mihaila, Alexey N. Butkevich, Stefan W. Hell
Pubblicato in: BioRxiv, 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.10.31.363424

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain

Autori: Tianyan Liu, Till Stephan, Peng Chen, Jingting Chen, Dietmar Riedel, Zhongtian Yang, Stefan Jakobs, Zhixing Chen
Pubblicato in: BioRxiv, Numero 26928205, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.05.09.491019

In-situ architecture of the human prohibitin complex

Autori: Felix Lange, Michael Ratz, Jan-Niklas Dohrke, Dirk Wenzel, Peter Ilgen, Dietmar Riedel, Stefan Jakobs
Pubblicato in: BioRxiv, 2025, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.14.579514

The Drosophila MIC10 orthologue has a propensity to polymerize into cristae-shaping filaments

Autori: Till Stephan, Stefan Stoldt, Mariam Barbot, Travis D. Carney, Felix Lange, Mark Bates, Peter Bou Dib, Halyna R. Shcherbata, Michael Meinecke, Dietmar Riedel, Sven Dennerlein, Peter Rehling, Stefan Jakobs
Pubblicato in: BioRxiv, 2023, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.04.17.537183

Optimal Precision and Accuracy in 4Pi-STORM using Dynamic Spline PSF Models

Autori: Mark Bates, Jan Keller-Findeisen, Adrian Przybylski, Andreas Hüper, Till Stephan, Peter Ilgen, Angel R. Cereceda Delgado, Elisa D’Este, Stefan Jakobs, Steffen J. Sahl, Stefan W. Hell
Pubblicato in: BioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.10.19.464803

Super-resolution microscopy of mitochondrial mRNAs

Autori: Stefan Stoldt, Frederike Maass, Michael Weber, Sven Dennerlein, Peter Ilgen, Jutta Gärtner, Aysenur Canfes, Sarah V. Schweighofer, Daniel C. Jans, Peter Rehling, Stefan Jakobs
Pubblicato in: BioRxiv, 2025, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.23.634455

Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria

Autori: Sarah Vanessa Schweighofer, Daniel C. Jans, Jan Keller-Findeisen, Anne Folmeg, Mark Bates, Stefan Jakobs
Pubblicato in: BioRxiv, 2025, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.08.18.553869

Structural insights into crista junction formation by the Mic60-Mic19 complex

Autori: Tobias Bock-Bierbaum, Kathrin Funck, Florian Wollweber, Elisa Lisicki, Janina Laborenz, Jeffrey K. Noel, Manuel Hessenberger, Alexander von der Malsburg, Karina von der Malsburg, Carola Bernert, Séverine Kunz, Dietmar Riedel, Hauke Lilie, Stefan Jakobs, Martin van der Laan, Oliver Daumke
Pubblicato in: BioRxiv, 2022, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.03.30.486340

MultiMatch: Geometry-Informed Colocalization in Multi-Color Super-Resolution Microscopy

Autori: Julia Naas, Giacomo Nies, Housen Li, Stefan Stoldt, Bernhard Schmitzer, Stefan Jakobs, Axel Munk
Pubblicato in: BioRxiv, 2025, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.28.581557