Project description DEENESFRITPL A novel automated assembly line turns out complex compounds that resemble natural products Protein synthesis is a complex multistep process that synthetic chemists have successfully harnessed to produce oligopeptides and oligonucleotides. A similar automated procedure opening the door to complex natural products is currently lacking. With the support of the Marie Skłodowska-Curie Actions programme, the PROTEAS project is combining two cutting-edge methodologies to address this barrier. The technology will enable rapid ‘assembly-line’ synthesis of linear terpene or terpenoid precursors followed by head-to-tail cyclisation using a novel supramolecular capsule catalyst. This will open the door to automated and rapid production of terpene-based compounds, the largest and most diverse group of naturally occurring compounds that form the major constituents of essential oils from plants. Show the project objective Hide the project objective Objective Recent advances in the development of iterative synthetic methodology (“assembly-line synthesis”) have the potential to bring about a paradigm shift in small molecule synthesis, by providing automated protocols similar to those used for oligopeptide and oligonucleotide synthesis. However, a clear limitation of such systems has been the synthesis of topologically complex frameworks. Drawing inspiration from Nature, this project aims to address this issue by providing an innovative protocol for the automated synthesis of complex natural product-like scaffolds. This will be done by combining two cutting-edge methodologies: (i) the automated synthetic platform developed by the Burke group in the University of Illinois at Urbana-Champaign, which can rapidly provide libraries of small molecules by the iterative coupling of N-methyliminodiacetic acid (MIDA) boronate building blocks, and (ii) a novel supramolecular capsule catalyst developed by the Tiefenbacher group at the University of Basel, which has the unique capability to catalyse the tail-to-head terpene cyclization, the same transformation employed by Nature to give rise to the myriad of known terpene structures. The Burke group’s small molecule synthesizer will thus be used to rapidly assemble linear terpenoid precursors, which will then be subjected to tail-to-head terpene cyclization via the Tiefenbacher group’s catalyst to form cyclized terpenoid structures. The project will identify factors that influence the course of the cyclization and develop methods to control it so that desired scaffolds are produced on-demand. At its conclusion, it aims to provide a platform for the automated preparation of natural product-like compounds that will greatly impact chemical biology and medicinal chemistry research. Fields of science medical and health sciencesbasic medicinemedicinal chemistrynatural scienceschemical sciencesorganic chemistryheterocyclic compounds Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2018 - Individual Fellowships Call for proposal H2020-MSCA-IF-2018 See other projects for this call Funding Scheme MSCA-IF-GF - Global Fellowships Coordinator UNIVERSITAT BASEL Net EU contribution € 260 840,64 Address Petersplatz 1 4051 Basel Switzerland See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS United States Net EU contribution € 0,00 Address 506 s. wright street, 209 hab, mc 339 61801 Urbana il See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 165 265,92
