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Brain Cancer Therapy Monitoring using a Novel Quantitative and Rapid Magnetic Resonance Imaging-based Method

Project description

MRI-based monitoring of oncolytic virotherapy in brain tumour models

Glioblastoma multiforme (GBM) is the most common type of fatal brain tumour found in adults. A promising therapeutic approach for GBM involves oncolytic viruses (OV) that selectively infect, multiply in and specifically destroy only tumour cells. Successful oncolytic virotherapy requires frequent non-invasive monitoring of the whole process. The goal of the EU-funded OncoViroMRI project is to develop an MRI-based application for accurate, quantitative and rapid imaging of OV delivery and spread in relevant tumour models. The proposed interdisciplinary methodology involves the genetic modification of the virus for MRI detection, the development of machine-learning methods to enhance the virus image-monitoring process and finally the evaluation using mice models of brain tumour therapy.

Call for proposal

H2020-MSCA-IF-2018
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Coordinator

TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD
Address
The Senate Building Technion City 1
32000 Haifa
Israel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 269 998,08

Partners (1)

Athinoula A. Martinos Center for Biomedical Imaging
United States
Address
Thirteenth Street, Suite 2301 149
02129 Charlestown
Activity type
Research Organisations