Brain Cancer Therapy Monitoring using a Novel Quantitative and Rapid Magnetic Resonance Imaging-based Method

Project description

MRI-based monitoring of oncolytic virotherapy in brain tumour models

Glioblastoma multiforme (GBM) is the most common type of fatal brain tumour found in adults. A promising therapeutic approach for GBM involves oncolytic viruses (OV) that selectively infect, multiply in and specifically destroy only tumour cells. Successful oncolytic virotherapy requires frequent non-invasive monitoring of the whole process. The goal of the EU-funded OncoViroMRI project is to develop an MRI-based application for accurate, quantitative and rapid imaging of OV delivery and spread in relevant tumour models. The proposed interdisciplinary methodology involves the genetic modification of the virus for MRI detection, the development of machine-learning methods to enhance the virus image-monitoring process and finally the evaluation using mice models of brain tumour therapy.

Fields of science

• natural sciences › biological sciences › microbiology › virology
• engineering and technology › medical engineering › diagnostic imaging › magnetic resonance imaging

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD

Address

The Senate Building Technion City 1
32000 Haifa
Israel

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU contribution

€ 269 998,08

Partners (1)

Athinoula A. Martinos Center for Biomedical Imaging

United States

Address

Thirteenth Street, Suite 2301 149
02129 Charlestown

Activity type

Research Organisations