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Identification and characterisation of new class of PI3K modulators in oncology

Project description

PI3K signalling activation as an anti-cancer strategy

Phosphoinositide 3-kinase (PI3K) signalling is central for many biological functions and exhibits aberrant regulation in cancer. The EU-funded PI3K MODULATORS project aims to hyper-activate PI3K signalling in white blood cells as a therapeutic intervention for haematological malignancies. For this purpose, researchers will undertake a high-throughput screening approach to discover small-molecule PI3K activators specific for the white blood cell isoform of PI3K. They will study the mode of action of these activators as well as the mechanism of PI3K-mediated cancer cell death through various structural and biochemical analyses. The project's results will pave the way for the exploitation of PI3K drugs in cancer therapy.


Net EU contribution
€ 212 933,76
Gower Street
WC1E 6BT London
United Kingdom

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London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00