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Identification and characterisation of new class of PI3K modulators in oncology

Project description

PI3K signalling activation as an anti-cancer strategy

Phosphoinositide 3-kinase (PI3K) signalling is central for many biological functions and exhibits aberrant regulation in cancer. The EU-funded PI3K MODULATORS project aims to hyper-activate PI3K signalling in white blood cells as a therapeutic intervention for haematological malignancies. For this purpose, researchers will undertake a high-throughput screening approach to discover small-molecule PI3K activators specific for the white blood cell isoform of PI3K. They will study the mode of action of these activators as well as the mechanism of PI3K-mediated cancer cell death through various structural and biochemical analyses. The project's results will pave the way for the exploitation of PI3K drugs in cancer therapy.

Coordinator

UNIVERSITY COLLEGE LONDON
Net EU contribution
€ 212 933,76
Address
Gower Street
WC1E 6BT London
United Kingdom

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00