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ASTRocyte Adrenoceptors: Light on Intracellular Signaling

Project description

Research sheds light on how astrocytes govern neural connections

Funded by the Marie Skłodowska-Curie Actions programme, the ASTRALIS project seeks to increase understanding of how intracellular signalling complexity is generated in the brain. The project will focus on brain cells called astrocytes that are highly interconnected but electrically silent and signal through G protein-coupled receptors and second messengers in response to norepinephrine. These brain cells will be used as models to study whether intracellular signalling in vivo is governed extrinsically or intrinsically. Elucidating the largely disregarded contribution of astrocytes in noradrenergic signalling at the cellular and network level should further understanding of the pathophysiology of related disorders and help conceive better therapeutic strategies.

Coordinator

MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Net EU contribution
€ 264 669,12
Address
Robert Rossle Strasse 10
13125 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Research Organisations
Other funding
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Net EU contribution
€ 0,00
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 177 265,92