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THE IMPACT OF THE ENVIRONMENT AND ONCOGENESIS ON CANCER CELL DIVISIONS

Project description

Insight into the ability of cancer cells to divide in challenging microenvironments

Mammalian cells must round up to divide, providing the space to develop a mitotic spindle for symmetric chromosomal segregation. If mitotic rounding is impeded by physical confinement or malfunction in adhesion remodelling, mitotic cell death may ensue. The EU-funded IEOCCD project aims to identify the mechanisms that allow epithelial cancer cells to divide in a challenging physical environment. Ras-activated epithelial cells are able to round better compared to normal cells, suggesting that Ras-ERK signalling plays a role in the mitotic rounding of cancer cells. The project will study a connection between Ras-ERK signalling and mitotic progression, linking oncogenesis to the ability of cancer cells to divide in a wide range of environments.

Coordinator

UNIVERSITY COLLEGE LONDON
Net EU contribution
€ 212 933,76
Address
Gower Street
WC1E 6BT London
United Kingdom

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00