DNA nanotechnology for improved diabetes management
The rapid advancement of sensing technologies requires biosensors capable of continuous monitoring in a single-step process. The performance of available biosensors is hampered by the binding strength of the molecular recognition unit, which limits the dynamic range of the sensor and is often connected to the signal output. The EU-funded GlucOrigami project proposes to decouple the molecular recognition and signal transduction units of the biosensor, using self-assembled and programmable DNA origami nanostructures. The solution will be demonstrated by the model of a glucose biosensor for disease monitoring in diabetic patients, with the DNA origami used to accurately position all biosensor elements: a multifluorophore pair as a signal transduction and amplification unit, and glucose/galactose binding proteins as a molecular recognition unit.
Fields of science
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesclinical medicineendocrinologydiabetes
- natural sciencesphysical sciencesopticsspectroscopy
- natural sciencesbiological sciencesmolecular biology