Project description
Metabolic and immune responses crosstalk in the course of tuberculosis
Tuberculosis (TB) is a major health problem worldwide. Promising TB treatments with host-directed therapeutics require a comprehensive understanding of host-pathogen interactions' impact on signalling pathways and cellular responses related to disease outcome. Metabolic reprogramming of immune cells that occurs during infection results in active glycolysis and lactate production. Lactate is a signalling molecule, and macrophages can respond to it through different transporters. The goal of the EU-funded Lac-TB project is to investigate the crosstalk between metabolic and immune responses during TB infection with a particular focus on the macrophage responses to lactate. The project has the potential to identify new host immune-metabolic therapeutic targets for TB.
Objective
Tuberculosis (TB) is a major global public health problem in which one-fourth of the world’s population is latently infected. Host-directed therapeutics are a promising approach; however, we require a comprehensive understanding of how host-pathogen interactions impact signalling pathways and cellular responses to dictate disease outcome.
Metabolic reprogramming of immune cells has been described during Mycobacterium tuberculosis (M.tb) infection, resulting in active glycolysis and lactate production. Lactate is an active signalling molecule and macrophages, the main M.tb cell target, can respond to it through different transporters.
The main aim of this project is to investigate the crosstalk between metabolic and immune responses in the context of M.tb infection, with a particular focus on macrophage responses to lactate. This project has the potential of revealing new host immune-metabolic therapeutic targets for TB disease.
Birmingham has one of the highest rates of TB in the UK and University of Birmingham (UoB) is a world-reference institution for metabolic and metabolomic studies. Dr Llibre has a strong background in immunology and moving to Dr Mauro’s laboratory at UoB will provide her with a rare opportunity to obtain a unique skillset, allowing her to study cell metabolism in high resolution. The expertise, facilities and supervisory team at the host institution, together with Dr Llibre’s extensive knowledge on immunology and infectious disease ensure the feasibility of this project. UoB will provide Dr Llibre a privileged environment to fully develop all the skills required to lead a successful research group, including training in scientific communication; opportunities for supervising and teaching, for learning how to coordinate a project and protect intellectual property. At the end of the fellowship, Dr Llibre will be at the forefront of the much needed and exciting field of immuno-metabolism, equipped to secure funding as an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine pneumology tuberculosis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.