Descripción del proyecto
Nanopartículas catalíticas para una activación farmacológica localizada
En la administración de fármacos, los nuevos métodos de administración focal pueden sumarse a los sistemas convencionales de administración y a las estrategias con profármacos y, de este modo, evitar los efectos secundarios y la farmacorresistencia, así como aumentar la eficacia. El proyecto GOLDEN, financiado con fondos europeos, propone sortear la maquinaria metabólica de las células y producir moléculas bioactivas en ubicaciones específicas en el organismo mediante nanopartículas (NP) metálicas. Las NP basadas en el oro sirven como catalizadores biocompatibles y pueden diseñarse para alcanzar específicamente las células cancerosas y convertir en fármacos los precursores bioactivos administrados de forma sistemática. Los investigadores utilizarán el pez cebra como modelo para probar la eficacia de la estrategia basada en NP de GOLDEN de activar tintes y neuromoduladores en el encéfalo y de allanar el camino para el tratamiento de trastornos localizados y dolor crónico.
Objetivo
"Despite recent advances in cancer therapy, many challenges remain to reduce the systemic adverse effects of antineoplastic therapeutics. A major goal in the field is to make nanomedical devices that could bypass the metabolic machinery of cells and perform tasks that are not possible with biological entities, such as the manufacture of bioactive molecules at specific locations in a continuous, atomically precise manner. The use of metallic nanoparticles (NPs) as biocompatible catalysts provides the opportunity to carry out abiotic catalysis inside cancer cells or tissues. Such bioorthogonal reactivity opens up new unprecedented ways of mediating artificial transformations in complex biological systems.
Solid supported Au-NPs have recently demonstrated a novel, very promising role as heterogeneous catalysts able to generate bioactive compounds in biological environments. Herein I propose an innovative approach to develop catalytically- active Au-NPs immobilized within implants or ""protected"" under self-assembling monolayers to enable the activation of systemically-administered bioactive precursors at specific locations via novel Au-mediated deprotection chemistry. To confirm the in vivo functional capabilities of the devices, I will test the capacity of the novel devices to activate dyes and neuromodulators in the brain of zebrafish. This highly innovative multidisciplinary approach could offer a unique and safe method to release bioactive molecules in exact anatomical locations for the treatment of localized disorders including cancer or chronic pain and, in doing so, promote Scientific Excellence in Europe. As the recipient of the advanced training required to perform such a novel programme of research and developer of such tools, at the end of this fellowship I will reach a privileged position for establishing myself as an independent researcher and starting cross-disciplinary collaborations with academics and Pharma across Europe."
Ámbito científico
Programa(s)
Régimen de financiación
MSCA-IF-EF-ST - Standard EFCoordinador
EH8 9YL Edinburgh
Reino Unido