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Gold-Functionalized Devices and Engineered Nanoparticles: Bioorthogonal Tools for Unprecedented Biomedical Applications

Projektbeschreibung

Katalytische Nanopartikel für eine lokalisierte Wirkstoffaktivierung

Bei der Wirkstoffabgabe können neue zentrale Abgabeansätze entsprechende konventionelle Systeme und Prodrug-Strategien ergänzen, wodurch Nebenwirkungen und Arzneimittelresistenz vermieden werden und eine höhere Wirksamkeit erzielt wird. Das EU-finanzierte Projekt GOLDEN schlägt vor, mithilfe metallischer Nanopartikel den Zellstoffwechsel zu umgehen und bioaktive Moleküle an bestimmten Stellen im Körper zu produzieren. Nanopartikel auf Goldbasis dienen als biokompatible Katalysatoren und können so konstruiert werden, dass sie insbesondere Krebszellen erreichen und systemisch verabreichte bioaktive Vorstufen in Wirkstoffe umwandeln. Das Forschungsteam wird die Wirksamkeit der Nanopartikel-Strategie von GOLDEN anhand eines Zebrafischmodells bei aktivierenden Farbstoffen und Neuromodulatoren im Hirn prüfen und damit den Weg für die Behandlung lokalisierter Erkrankungen und chronischer Schmerzen bereiten.

Ziel

"Despite recent advances in cancer therapy, many challenges remain to reduce the systemic adverse effects of antineoplastic therapeutics. A major goal in the field is to make nanomedical devices that could bypass the metabolic machinery of cells and perform tasks that are not possible with biological entities, such as the manufacture of bioactive molecules at specific locations in a continuous, atomically precise manner. The use of metallic nanoparticles (NPs) as biocompatible catalysts provides the opportunity to carry out abiotic catalysis inside cancer cells or tissues. Such bioorthogonal reactivity opens up new unprecedented ways of mediating artificial transformations in complex biological systems.
Solid supported Au-NPs have recently demonstrated a novel, very promising role as heterogeneous catalysts able to generate bioactive compounds in biological environments. Herein I propose an innovative approach to develop catalytically- active Au-NPs immobilized within implants or ""protected"" under self-assembling monolayers to enable the activation of systemically-administered bioactive precursors at specific locations via novel Au-mediated deprotection chemistry. To confirm the in vivo functional capabilities of the devices, I will test the capacity of the novel devices to activate dyes and neuromodulators in the brain of zebrafish. This highly innovative multidisciplinary approach could offer a unique and safe method to release bioactive molecules in exact anatomical locations for the treatment of localized disorders including cancer or chronic pain and, in doing so, promote Scientific Excellence in Europe. As the recipient of the advanced training required to perform such a novel programme of research and developer of such tools, at the end of this fellowship I will reach a privileged position for establishing myself as an independent researcher and starting cross-disciplinary collaborations with academics and Pharma across Europe."

Koordinator

THE UNIVERSITY OF EDINBURGH
Netto-EU-Beitrag
€ 212 933,76
Adresse
OLD COLLEGE, SOUTH BRIDGE
EH8 9YL Edinburgh
Vereinigtes Königreich

Auf der Karte ansehen

Region
Scotland Eastern Scotland Edinburgh
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 212 933,76