Periodic Reporting for period 1 - HarmonizATforms (Defining the antithrombin measurand: role of proteoforms in harmonisation of diagnostic tests in thrombosis)
Berichtszeitraum: 2019-05-01 bis 2021-04-30
Based on this work we were able to present to researchers and clinicians at several (online) conferences, including the annual symposium of the American Society for Mass Spectrmetry, The Dutch Society for Clinical Chemistry and in July 2021 the International Society for Thrombosis and Hemostasis. Moreover, based on our work, we have initiated collaborations with the University of Murcia on the characterization of AT in clinical samples, and within the LUMC, the department of internal medicine, with whom we collaborate on the application of the development strategy established in our work on other proteins in the coagulation cascade. The work has thus far resulted in 2 peer reviewed publications, and we were also able to guide 3 bachelor and master students during their final internships. Due to the COVID pandemic, and the not yet clinical applicability of the current results, the outreach of to the general public has been limited.
Besides the direct impact on antithrombin testing, we are now also involved in collaborations addressing the biochemical functionality of antithrombin as well as the expansion of the developed method to other proteins in the coagulation cascade and fibrinolytic system.