Oxidative stress and ageing-related pathways as the targets to prevent Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder and affects an estimated 1 % of the world's population over 60. The pathogenetic triggers of PD are mostly unknown, and current treatments only partially alleviate symptoms and do not restore normal neuronal function. The EU-funded PARNANT project will capitalise on the partners' expertise in C. elegans genetics and cell-based PD models to find the genetic pathways that mediate protection against neurodegeneration during oxidative stress and ageing. Previous studies identified 51 candidate genetic loci associated with age-related neurodegeneration in PD models and patients. Researchers aim to target these genes to alleviate the oxidative stress in the dopaminergic neurons and protect them against degeneration.
Fields of science
Call for proposalSee other projects for this call
Funding SchemeMSCA-IF-EF-RI - RI – Reintegration panel
See on map