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Pathogenetic pathways in age-related neurodegenerations as novel therapeutic targets for Parkinson’s disease

Project description

Oxidative stress and ageing-related pathways as the targets to prevent Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder and affects an estimated 1 % of the world's population over 60. The pathogenetic triggers of PD are mostly unknown, and current treatments only partially alleviate symptoms and do not restore normal neuronal function. The EU-funded PARNANT project will capitalise on the partners' expertise in C. elegans genetics and cell-based PD models to find the genetic pathways that mediate protection against neurodegeneration during oxidative stress and ageing. Previous studies identified 51 candidate genetic loci associated with age-related neurodegeneration in PD models and patients. Researchers aim to target these genes to alleviate the oxidative stress in the dopaminergic neurons and protect them against degeneration.


Net EU contribution
€ 183 473,28
Viale Druso 1
39100 Bolzano

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Nord-Est Provincia Autonoma di Bolzano/Bozen Bolzano-Bozen
Activity type
Research Organisations
Other funding
€ 0,00