Pathogenetic pathways in age-related neurodegenerations as novel therapeutic targets for Parkinson’s disease

Project description

Oxidative stress and ageing-related pathways as the targets to prevent Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder and affects an estimated 1 % of the world's population over 60. The pathogenetic triggers of PD are mostly unknown, and current treatments only partially alleviate symptoms and do not restore normal neuronal function. The EU-funded PARNANT project will capitalise on the partners' expertise in C. elegans genetics and cell-based PD models to find the genetic pathways that mediate protection against neurodegeneration during oxidative stress and ageing. Previous studies identified 51 candidate genetic loci associated with age-related neurodegeneration in PD models and patients. Researchers aim to target these genes to alleviate the oxidative stress in the dopaminergic neurons and protect them against degeneration.

Fields of science

• natural sciences › biological sciences › neurobiology
• natural sciences › biological sciences › genetics
• medical and health sciences › basic medicine › neurology › dementia › alzheimer
• medical and health sciences › basic medicine › neurology › parkinson

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

ACCADEMIA EUROPEA DI BOLZANO

Net EU contribution

€ 183 473,28

Address

Viale Druso 1
39100 Bolzano
Italy

Region

Nord-Est › Provincia Autonoma di Bolzano/Bozen › Bolzano-Bozen

Activity type

Research Organisations

Links

Other funding

€ 0,00