Detecting Polygenic Adaptation Targeting Gene Expression Regulation In Humans Using eQTL Networks.

Project description

New insights into human genetic variation

Many human traits are highly polygenic and are governed by multiple genetic loci. The adaptation of such complex phenotypes takes place through small changes in allele frequencies at these loci. The EU-funded PATTERNS project proposes to study how polygenic adaptation may act on complex phenotypes through gene expression regulation, an aspect that has largely been overlooked. Scientists will combine network biology and population genetics methods to study the impact of polygenic adaptation on gene expression regulation. Results will provide a better understanding of how polygenic adaptation drives genetic diversity in humans and the extent to which it contributes to diseases.

Fields of science

• natural sciences › biological sciences › genetics
• natural sciences › mathematics › pure mathematics › discrete mathematics › graph theory

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Net EU contribution

€ 184 707,84

Address

Rue Michel Ange 3
75794 Paris
France

Region

Ile-de-France › Ile-de-France › Paris

Activity type

Research Organisations

Links

Other funding

€ 0,00