The pathogen genetics behind the clinical forms of leprosy
Leprosy is caused by Mycobacterium leprae and Mycobacterium lepromatosis, which are difficult to study as they cannot be cultivated in the laboratory. The recent sequencing of different bacterial isolates has identified hypermutated genes with potential roles in drug resistance and species adaptation. The scope of the EU-funded LEPVORS project is to associate these genetic changes with clinical phenotype and drug resistance. Moreover, using recent molecular advances such as next generation sequencing, researchers will study additional strains isolated from rarer clinical forms of leprosy. Results will provide unprecedented insight into the biology and host adaptation of the causative agent of leprosy.
Fields of science
Funding SchemeMSCA-IF-GF - Global Fellowships
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
80523 2001 Fort Collins
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