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Identification and characterization of new drug resistance and host adaptation mechanisms in Mycobacterium leprae

Project description

The pathogen genetics behind the clinical forms of leprosy

Leprosy is caused by Mycobacterium leprae and Mycobacterium lepromatosis, which are difficult to study as they cannot be cultivated in the laboratory. The recent sequencing of different bacterial isolates has identified hypermutated genes with potential roles in drug resistance and species adaptation. The scope of the EU-funded LEPVORS project is to associate these genetic changes with clinical phenotype and drug resistance. Moreover, using recent molecular advances such as next generation sequencing, researchers will study additional strains isolated from rarer clinical forms of leprosy. Results will provide unprecedented insight into the biology and host adaptation of the causative agent of leprosy.

Coordinator

SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT
Net EU contribution
€ 153 916,20
Address
Kreuzstrasse 2
4123 Allschwil
Switzerland

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Landschaft
Activity type
Research Organisations
Other funding
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BOARD OF GOVERNORS OF THE COLORADO STATE UNIVERSITY SYSTEM
United States
Net EU contribution
€ 0,00
Address
Colorado State University
80523 2001 Fort Collins

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 93 828,84