Novel biosensors for the microbial production factories
Microbial cell factories represent an economical and sustainable alternative for the production of pharmaceuticals and industrial chemicals. The lack of high-throughput methods for monitoring product accumulation is one of the obstacles in this process. The EU-funded GPCR-Sensor project aims to use G-protein coupled receptors (GPCRs), the eukaryotes' environmental sensors, to create a versatile in vivo biosensor. The research will apply synthetic biology and an interdisciplinary approach to develop a yeast-based GPCR biosensor for the engineering of enzymes and production hosts. The modular biosensor structure will allow any GPCR to be plugged in, enabling a variety of applications, both biomedical and environmental.
Fields of science
- engineering and technologyindustrial biotechnologymetabolic engineering
- engineering and technologychemical engineeringbiochemical engineering
- engineering and technologyenvironmental biotechnologybiosensing
- natural sciencesbiological sciencessynthetic biology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes