GPCR-based biosensor for synthetic biology applications

Project description

Novel biosensors for the microbial production factories

Microbial cell factories represent an economical and sustainable alternative for the production of pharmaceuticals and industrial chemicals. The lack of high-throughput methods for monitoring product accumulation is one of the obstacles in this process. The EU-funded GPCR-Sensor project aims to use G-protein coupled receptors (GPCRs), the eukaryotes' environmental sensors, to create a versatile in vivo biosensor. The research will apply synthetic biology and an interdisciplinary approach to develop a yeast-based GPCR biosensor for the engineering of enzymes and production hosts. The modular biosensor structure will allow any GPCR to be plugged in, enabling a variety of applications, both biomedical and environmental.

Fields of science

• engineering and technology › industrial biotechnology › metabolic engineering
• engineering and technology › chemical engineering › biochemical engineering
• engineering and technology › environmental biotechnology › biosensing
• natural sciences › biological sciences › synthetic biology
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

See other projects for this call

Funding Scheme

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

Coordinator

KOBENHAVNS UNIVERSITET

Net EU contribution

€ 207 312,00

Address

Norregade 10
1165 Kobenhavn
Denmark

Region

Danmark › Hovedstaden › Byen København

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00