Project description DEENESFRITPL Your heart needs a good night’s sleep Obstructive sleep apnoea (OSA) increases risks for cardiovascular disease – coronary artery disease, congestive heart failure and stroke. The underlying reasons behind this complex association between sleep disordered breathing and cardiovascular disease are not entirely defined. Experimental observation and data analysis are crucial to identify the mechanisms at work. The EU-funded DEEPDREAM project is combining advanced computational modelling, signal processing and interpretation techniques to assess the activation of the neural mechanisms related to intermittent hypoxia. The results will bring us one step closer to the prevention of cardiovascular diseases. Show the project objective Hide the project objective Objective Prediction is crucial to reduce the risk of cardiovascular complications caused by CRDs, a significant public health issue. Intermittent hypoxia caused by obstructive sleep apnea (OSA) is known to contribute to impaired autonomic cardiac function, but the impact of apneas severity on autonomic cardiac function remains unclear. Prediction is performed by using biomarkers, which can be proposed only if the pathophysiological mechanisms which link the severity of sleep apneas with heart rate variability alterations become clearer. A crucial condition to clarify these mechanisms is a close and continuous interaction between experimental observations and data analysis/modeling. This project, which combined advanced computational modeling and signal processing and interpretation techniques to assess the activation of the neural mechanisms related to intermittent hypoxia, offers a concrete possibility to go one step further in the prevention of cardiovascular diseases in OSA. Fields of science medical and health sciencesclinical medicinepsychiatrysleep disordersmedical and health scienceshealth sciencespublic healthmedical and health scienceshealth sciencesinfectious diseasesRNA virusescoronavirusesnatural sciencescomputer and information sciencescomputational sciencemedical and health sciencesclinical medicinecardiologycardiovascular diseases Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2018 - Individual Fellowships Call for proposal H2020-MSCA-IF-2018 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Net EU contribution € 172 932,48 Address Carrer baldiri reixac planta 2a 10-12 08028 Barcelona Spain See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
