A Data-drivEn computational mEthod for PersonalizeD healthcare in chronic REspiratory diseases through big-dAta analytics and dynamical Modelling.

Project Information

DEEPDREAM

Grant agreement ID: 846636

DOI 10.3030/846636

Project closed

EC signature date 19 March 2019

Start date 1 March 2020

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 172 932,48

EU contribution € 172 932,48

Coordinated by

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

Project description

Your heart needs a good night’s sleep

Obstructive sleep apnoea (OSA) increases risks for cardiovascular disease – coronary artery disease, congestive heart failure and stroke. The underlying reasons behind this complex association between sleep disordered breathing and cardiovascular disease are not entirely defined. Experimental observation and data analysis are crucial to identify the mechanisms at work. The EU-funded DEEPDREAM project is combining advanced computational modelling, signal processing and interpretation techniques to assess the activation of the neural mechanisms related to intermittent hypoxia. The results will bring us one step closer to the prevention of cardiovascular diseases.

Objective

Prediction is crucial to reduce the risk of cardiovascular complications caused by CRDs, a significant public health issue. Intermittent hypoxia caused by obstructive sleep apnea (OSA) is known to contribute to impaired autonomic cardiac function, but the impact of apneas severity on autonomic cardiac function remains unclear.

Prediction is performed by using biomarkers, which can be proposed only if the pathophysiological mechanisms which link the severity of sleep apneas with heart rate variability alterations become clearer. A crucial condition to clarify these mechanisms is a close and continuous interaction between experimental observations and data analysis/modeling.

This project, which combined advanced computational modeling and signal processing and interpretation techniques to assess the activation of the neural mechanisms related to intermittent hypoxia, offers a concrete possibility to go one step further in the prevention of cardiovascular diseases in OSA.

Fields of science

• medical and health sciences › clinical medicine › psychiatry › sleep disorders
• medical and health sciences › health sciences › public health
• medical and health sciences › health sciences › infectious diseases › RNA viruses › coronaviruses
• natural sciences › computer and information sciences › computational science
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2018 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2018

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA

• Net EU contribution: € 172 932,48
• Address: CARRER BALDIRI REIXAC PLANTA 2A 10-12 ; 08028 Barcelona ; Spain
• Region: Este › Cataluña › Barcelona
• Activity type: Research Organisations
• Total cost: € 172 932,48