Periodic Reporting for period 1 - MetALS (Investigating the pharmacokinetic properties of toxic metals and heat shock proteins as risk factors in Amyotrophic Lateral Sclerosis)
Berichtszeitraum: 2019-10-01 bis 2021-09-30
The aim of the MetALS study has been to collect single time point as well as longitudinal blood and urine samples from ALS patients and control participants for the purpose of lab measurement of toxic metals and potential ALS biomarkers such as creatinine and heat shock proteins. Subsequent statistical modelling is to be performed to determine if longitudinal trends differ in patients vs controls, to determine the prognostic importance if any of toxic metal concentrations, and to explore longitudinal heat shock proteins concentrations as biomarkers of progression in ALS.
Results of this Action will be reported in forthcoming research papers that will address 1) normative reference data for urinary metals in healthy Irish individuals, 2) a comparison of heat shock proteins between ALS patients and health controls at a single timepoint, 3) an analysis of the longitudinal trends in toxic metals and HSP’s in ALS cases versus controls, and 4) an analysis to determine if any of the metal concentrations or heat shock proteins have prognostic importance in ALS patients.