Personalized immunotherapy in sepsis: a precision medicine based approach

Project Information

ImmunoSep

Grant agreement ID: 847422

DOI

10.3030/847422

Project closed

EC signature date 5 December 2019

Start date 1 January 2020

End date 30 June 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 10 081 333,75

EU contribution

€ 10 081 333,75

Coordinated by

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (2)

Audio-visual material

Audiovisual material

Public project website

Documents, reports (3)

Report on the value proposition for future uptake of personalized immunotherapy in sepsis in ICU practice
First study approval package: final version of study protocol as approved by first regulator / ethics committee, registration in a WHO- or ICMJE- approved registry, approval for enrolment of first subject in at least one clinical centre
Report on status of posting results

Publications

Peer reviewed articles (14)

Modes of action and diagnostic value of miRNAs in sepsis

Author(s): Nikolaos Antonakos, Charly Gilbert, Charlotte Théroude, Irene T Schrijver, Thierry Roger
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2022.951798

The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation

Author(s): Rainer Knoll, Elisa T. Helbig, Kilian Dahm, Olufemi Bolaji, Frederik Hamm, Oliver Dietrich, Martina van Uelft, Sophie Müller, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Lev Petrov, Benjamin Krämer, Michael Kraut, Paula Stubbemann, Charlotte Thibeault, Sophia Brumhard, Heidi Theis, Gudrun Hack, Elena De Domenico, Jacob Nattermann, Matthias Becker, Marc D. Beyer, David Hillus, Philipp Georg, Cons
Published in: Cell, Issue 187, 2024, Page(s) 4318-4335.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.06.014

Whole blood stimulation as a tool for studying the human immune system

Author(s): Sophie Müller, Charlotte Kröger, Joachim L. Schultze, Anna C. Aschenbrenner
Published in: European Journal of Immunology, Issue 54, 2024, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202350519

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

Author(s): Antigone Kotsaki; Peter Pickkers; Michael Bauer; Thierry Calandra; Mihaela Lupse; W Joost Wiersinga; Sylvain Meylan; Frank Bloos; Tom van der Poll; Marleen A Slim; Niels van Mourik; Marcella C A Müller; Lonneke van Vught; Alexander P J Vlaar; Aline de Nooijer; Lieke Bakkerus; Sebastian Weis; Nikolaos Antonakos; Mihai G Netea; Evangelos J Giamarellos-Bourboulis
Published in: BMJ Open, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2022-067251

Editorial: Macrophage Plasticity in Sterile and Pathogen-Induced Inflammation

Author(s): Kourtzelis, Ioannis; Hewitson, James; Roger, Thierry
Published in: Frontiers in Immunology, Issue 4, 2021, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2021.823023

An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

Author(s): Amit Frishberg, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Leo AB Joosten, Joost HW Rutten, Adrian C Iancu, Ioana M Dregoesc, Bogdan A Tigu, Mihai G Netea, Niels P Riksen, Irit Gat-Viks
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61710

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

Author(s): George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G. Netea, Themistoklis Spyridopoulos, Rebecca J. Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L. van de Veerdonk, Evangelos J. Giamarellos-Bourboulis
Published in: Cell Host & Microbe, Issue 28/1, 2020, Page(s) 117-123.e1, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.05.007

Personalised immunotherapy in sepsis: a scoping review protocol

Author(s): Marleen A Slim; Niels van Mourik; Joanna C Dionne; Simon J W Oczkowski; M G Netea; Peter Pickkers; Evangelos J Giamarellos-Bourboulis; Marcella C A Müller; Tom van der Poll; W Joost Wiersinga; Alexander P J Vlaar; Lonneke A van Vught
Published in: BMJ Open, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-060411

Myeloid-Derived Suppressor-like Cells as a Prognostic Marker in Critically Ill Patients: Insights from Experimental Endotoxemia and Intensive Care Patients

Author(s): Irene T. Schrijver, Jacobus Herderschee, Charlotte Théroude, Antonios Kritikos, Guus Leijte, Didier Le Roy, Maelick Brochut, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Benoit Guery, Matthijs Kox, Peter Pickkers, Thierry Calandra, Thierry Roger
Published in: Cells, 2024, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells13040314

Sepsis: deriving biological meaning and clinical applications from high-dimensional data.

Author(s): Alex R. Schuurman; Tom D Y Reijnders; Robert F. J. Kullberg; Joe M. Butler; Tom van der Poll; W. Joost Wiersinga
Published in: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-15 (2021), 2021, ISSN 2197-425X
Publisher: Springer
DOI: 10.1186/s40635-021-00383-x

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Author(s): Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini
Published in: Cell Host & Microbe, Issue 27/6, 2020, Page(s) 992-1000.e3, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.04.009

The pathophysiology of sepsis and precision-medicine-based immunotherapy

Author(s): Evangelos J. Giamarellos-Bourboulis, Anna C. Aschenbrenner, Michael Bauer, Christoph Bock, Thierry Calandra, Irit Gat-Viks, Evdoxia Kyriazopoulou, Mihaela Lupse, Guillaume Monneret, Peter Pickkers, Joachim L. Schultze, Tom van der Poll, Frank L. van de Veerdonk, Alexander P. J. Vlaar, Sebastian Weis, W. Joost Wiersinga, Mihai G. Netea
Published in: Nature Immunology, Issue 25, 2024, Page(s) 19-28, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-023-01660-5

Reconstructing disease dynamics for mechanistic insights and clinical benefit

Author(s): Amit Frishberg, Neta Milman, Ayelet Alpert, Hannah Spitzer, Ben Asani, Johannes B. Schiefelbein, Evgeny Bakin, Karen Regev-Berman, Siegfried G. Priglinger, Joachim L. Schultze, Fabian J. Theis, Shai S. Shen-Orr
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42354-8

Towards personalized medicine: a scoping review of immunotherapy in sepsis

Author(s): Marleen A. Slim, Niels van Mourik, Lieke Bakkerus, Katherine Fuller, Lydia Acharya, Tatiana Giannidis, Joanna C. Dionne, Simon J. W. Oczkowski, Mihai G. Netea, Peter Pickkers, Evangelos J. Giamarellos-Bourboulis, Marcella C. A. Müller, Tom van der Poll, W. Joost Wiersinga, null null, Bart-Jan Kullberg, Aline Nooijer, Frank Veerdonk, Jaap Oever, Jacobien Hoogerwerf, Marlies Hulscher, Mihai Netea,
Published in: Critical Care, Issue 28, 2024, ISSN 1364-8535
Publisher: Springer Nature
DOI: 10.1186/s13054-024-04964-6

Non-peer reviewed articles (2)

Editorial: Beneficial and pathological roles of myeloid cells during COVID-19.

Author(s): Lokesh Sharma; Shaon Sengupta; Thierry Roger
Published in: Frontiers in immunology, vol. 14, pp. 1194826, Issue 4, 2023, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1194826

Editorial: The Immunology of Sepsis-Understanding Host Susceptibility, Pathogenesis of Disease, and Avenues for Future Treatment.

Author(s): Luregn J. Schlapbach; Luregn J. Schlapbach; Johannes Trück; Thierry Roger
Published in: Frontiers in Immunology, Issue 6, 2020, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.01263