Personalized immunotherapy in sepsis: a precision medicine based approach

Project Information

ImmunoSep

Grant agreement ID: 847422

DOI 10.3030/847422

Project closed

EC signature date 5 December 2019

Start date 1 January 2020

End date 30 June 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 10 081 333,75

EU contribution € 10 081 333,75

Coordinated by

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands

Deliverables

Websites, patent fillings, videos etc. (2)

Audio-visual material

Audiovisual material

Public project website

Documents, reports (1)

First study approval package: final version of study protocol as approved by first regulator / ethics committee, registration in a WHO- or ICMJE- approved registry, approval for enrolment of first subject in at least one clinical centre

Publications

Peer reviewed articles (9)

Modes of action and diagnostic value of miRNAs in sepsis

Author(s): Nikolaos Antonakos, Charly Gilbert, Charlotte Théroude, Irene T Schrijver, Thierry Roger
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2022.951798

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol

Author(s): Antigone Kotsaki; Peter Pickkers; Michael Bauer; Thierry Calandra; Mihaela Lupse; W Joost Wiersinga; Sylvain Meylan; Frank Bloos; Tom van der Poll; Marleen A Slim; Niels van Mourik; Marcella C A Müller; Lonneke van Vught; Alexander P J Vlaar; Aline de Nooijer; Lieke Bakkerus; Sebastian Weis; Nikolaos Antonakos; Mihai G Netea; Evangelos J Giamarellos-Bourboulis
Published in: BMJ Open, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2022-067251

Editorial: Macrophage Plasticity in Sterile and Pathogen-Induced Inflammation

Author(s): Kourtzelis, Ioannis; Hewitson, James; Roger, Thierry
Published in: Frontiers in Immunology, Issue 4, 2021, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2021.823023

An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

Author(s): Amit Frishberg, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Leo AB Joosten, Joost HW Rutten, Adrian C Iancu, Ioana M Dregoesc, Bogdan A Tigu, Mihai G Netea, Niels P Riksen, Irit Gat-Viks
Published in: eLife, Issue 10, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.61710

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

Author(s): George Dimopoulos, Quirijn de Mast, Nikolaos Markou, Maria Theodorakopoulou, Apostolos Komnos, Maria Mouktaroudi, Mihai G. Netea, Themistoklis Spyridopoulos, Rebecca J. Verheggen, Jacobien Hoogerwerf, Alexandra Lachana, Frank L. van de Veerdonk, Evangelos J. Giamarellos-Bourboulis
Published in: Cell Host & Microbe, Issue 28/1, 2020, Page(s) 117-123.e1, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.05.007

Personalised immunotherapy in sepsis: a scoping review protocol

Author(s): Marleen A Slim; Niels van Mourik; Joanna C Dionne; Simon J W Oczkowski; M G Netea; Peter Pickkers; Evangelos J Giamarellos-Bourboulis; Marcella C A Müller; Tom van der Poll; W Joost Wiersinga; Alexander P J Vlaar; Lonneke A van Vught
Published in: BMJ Open, 2022, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-060411

Myeloid-Derived Suppressor-like Cells as a Prognostic Marker in Critically Ill Patients: Insights from Experimental Endotoxemia and Intensive Care Patients

Author(s): Irene T. Schrijver, Jacobus Herderschee, Charlotte Théroude, Antonios Kritikos, Guus Leijte, Didier Le Roy, Maelick Brochut, Jean-Daniel Chiche, Matthieu Perreau, Giuseppe Pantaleo, Benoit Guery, Matthijs Kox, Peter Pickkers, Thierry Calandra, Thierry Roger
Published in: Cells, 2024, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells13040314

Sepsis: deriving biological meaning and clinical applications from high-dimensional data.

Author(s): Alex R. Schuurman; Tom D Y Reijnders; Robert F. J. Kullberg; Joe M. Butler; Tom van der Poll; W. Joost Wiersinga
Published in: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-15 (2021), 2021, ISSN 2197-425X
Publisher: Springer
DOI: 10.1186/s40635-021-00383-x

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

Author(s): Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea, Nikoletta Rovina, Karolina Akinosoglou, Anastasia Antoniadou, Nikolaos Antonakos, Georgia Damoraki, Theologia Gkavogianni, Maria-Evangelia Adami, Paraskevi Katsaounou, Maria Ntaganou, Magdalini Kyriakopoulou, George Dimopoulos, Ioannis Koutsodimitropoulos, Dimitrios Velissaris, Panagiotis Koufargyris, Athanassios Karageorgos, Konstantina Katrini
Published in: Cell Host & Microbe, Issue 27/6, 2020, Page(s) 992-1000.e3, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2020.04.009

Non-peer reviewed articles (2)

Editorial: Beneficial and pathological roles of myeloid cells during COVID-19.

Author(s): Lokesh Sharma; Shaon Sengupta; Thierry Roger
Published in: Frontiers in immunology, vol. 14, pp. 1194826, Issue 4, 2023, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2023.1194826

Editorial: The Immunology of Sepsis-Understanding Host Susceptibility, Pathogenesis of Disease, and Avenues for Future Treatment.

Author(s): Luregn J. Schlapbach; Luregn J. Schlapbach; Johannes Trück; Thierry Roger
Published in: Frontiers in Immunology, Issue 6, 2020, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2020.01263