Host directed medicine in invasive fungal infection

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Report on journalistic and scientific immunotherapy narratives

An analysis will be performed of the Englishlanguage journalistic and scientific discourse surrounding immunotherapy for infections

Development of project website and project visual identity

Development of a project website and of a logo that visually identifies the project and allow people to recognise the HDMFUN message at the first glance

Publications

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Auteurs: Simon Feys, MD Samuel M Gonçalves, MSc * Mona Khan, PhD * Sumin Choi, MSc * Bram Boeckx, PhD Denis Chatelain, MD Cristina Cunha, PhD Yves Debaveye, MD Prof Greet Hermans, MD Marjan Hertoghs, MD Steph
Publié dans: The Lancet Respiratory Medicine, Numéro monthly, 2022, Page(s) P1147-1159
Éditeur: Elsevier
DOI: 10.1016/s2213-2600(22)00259-4

Enteric delivery of indole-3-carboxylic acid unlocks therapeutic potential of postbiotic metabolite cascade

Auteurs: Matteo Puccetti, Marilena Pariano, Claudia Stincardini, Consuelo Fabi, Roberta Galarini, Carolina Barola, Husam Br. Alabed, Dorotea Frongia Mancini, Roberto Maria Pellegrino, Enrico Garaci, Maurizio Ricci, Luigina Romani, Stefano Giovagnoli
Publié dans: International Journal of Pharmaceutics, Numéro 684, 2025, Page(s) 126158, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.126158

Rapidly expanded partially HLA DRB1–matched fungus-specific T cells mediate in vitro and in vivo antifungal activity

Auteurs: Gloria Castellano-González, Helen M. McGuire, Fabio Luciani, Leighton E. Clancy, Ziduo Li, Selmir Avdic, Brendan Hughes, Mandeep Singh, Barbara Fazekas de St Groth, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Luigina Romani, David J. Gottlieb
Publié dans: Blood Advances, Numéro 4/14, 2020, Page(s) 3443-3456, ISSN 2473-9529
Éditeur: Europe PMC
DOI: 10.1182/bloodadvances.2020001565

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway

Auteurs: Jia, Lei-Jie; Rafiq, Muhammad; Radosa, Lukáš; Hortschansky, Peter; Cunha, Cristina; Cseresnyés, Zoltán; Krüger, Thomas; Schmidt, Franziska; Heinekamp, Thorsten; Straßburger, Maria; Löffler, Bettina; Doenst, Torsten; Lacerda, João; Campos, António; Figge, Marc Thilo; Carvalho, Agostinho; Kniemeyer, Olaf; Brakhage, Axel A.
Publié dans: Cell Host Microb, Numéro 31 (3), 2023, Page(s) 16, ISSN 1934-6069
Éditeur: Cell Press
DOI: 10.1016/j.chom.2023.02.002

Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation

Auteurs: da Silva-Ferreira S, Duarte-Oliveira C, Antunes D, Barbosa-Matos C, Mendes-Frias A, Torrado E, Costa S, Silvestre R, Cunha C, Carvalho A
Publié dans: Frontiers in Cellular and Infection Microbiology, Numéro 12, 2022, Page(s) 1005839, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.1005839

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

Auteurs: Jose Manuel Sánchez-Maldonado, Ana Moñiz-Díez, Rob ter Horst, Daniele Campa, Antonio José Cabrera-Serrano, Manuel Martínez-Bueno, María del Pilar Garrido-Collado, Francisca Hernández-Mohedo, Laura Fernández-Puerta, Miguel Ángel López-Nevot, Cristina Cunha, Pedro Antonio González-Sierra, Jan Springer, Michaela Lackner, Laura Alcazar-Fuoli, Luana Fianchi, José María Aguado, Livio Pagano
Publié dans: Journal of Fungi, Numéro 7/1, 2021, Page(s) 4, ISSN 2309-608X
Éditeur: -
DOI: 10.3390/jof7010004

Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study.

Auteurs: Feys S, Vanmassenhove S, Kraisin S, Yu K, Jacobs C, Boeckx B, Cambier S, Cunha C, Debaveye Y, Gonçalves SM, Hermans G, Humblet-Baron S, Jansen S, Lagrou K, Meersseman P, Neyts J, Peetermans M, Rocha-
Publié dans: The Lancet Microbe., Numéro 5(3), 2024, Page(s) e247-e260.
Éditeur: Elsevier Ltd.
DOI: 10.1016/s2666-5247(23)00368-3

Harnessing inter-kingdom metabolic disparities at the human-fungal interface for novel therapeutic approaches.

Auteurs: Claudio Costantini, Marilena Pariano, Matteo Puccetti, Stefano Giovagnoli , Gioena Pampalone , Mirco Dindo , Barbara Cellini , Luigina Romani.
Publié dans: Front Mol Biosci, Numéro 11, 2024, Page(s) 1386598, ISSN 1746-2665
Éditeur: Frontiers
DOI: 10.3389/fmolb.2024.1386598

The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19

Auteurs: Arianna Di Stadio, Claudio Costantini, Giorgia Renga, Marilena Pariano, Giampietro Ricci, Luigina Romani
Publié dans: Life, Numéro 10/12, 2020, Page(s) 345, ISSN 2075-1729
Éditeur: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/life10120345

Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus

Auteurs: Daniela Antunes; Samuel M. Gonçalves; Vasiliki Matzaraki; Cláudia S. Rodrigues; Relber A. Gonçales; Joana Rocha; Jorge Sáiz; António Marques; Egídio Torrado; Ricardo Silvestre; Fernando Rodrigue
Publié dans: Microbiol Spectr, Numéro 11(1), 2023, Page(s) e0225622
Éditeur: American Society for Microbiology,
DOI: 10.1128/spectrum.02256-22

Aspergillus fumigatus and aspergillosis: From basics to clinics

Auteurs: Arastehfar A, Carvalho A, Houbraken J, Lombardi L, Garcia-Rubio R, Jenks JD, Rivero-Menendez O, Aljohani R, Jacobsen ID, Berman J, Osherov N, Hedayati MT, Ilkit M, Armstrong-James D, Gabaldón T, Mele
Publié dans: Studies in Mycology, Numéro May 10;100, 2021, Page(s) 100115
Éditeur: Westerdijk Fungal Biodiversity Institute
DOI: 10.1016/j.simyco.2021.100115

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

Auteurs: Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A, Gangneux JP, Nasir N, Bonifaz A, Araiza J, Klimko N, Serris A, Lagrou K, Meis JF, Cornely OA, Perfect JR, White PL, Chakrabarti A
Publié dans: Lancet Microbe, Numéro Jul;3(7), 2022, Page(s) e543-e552, ISSN 2666-5247
Éditeur: Elsevier
DOI: 10.1016/s2666-5247(21)00237-8

Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of disease

Auteurs: Stejara A. Netea, Giske Biesbroek, Diana van Stijn, Hanna Ijspeert, Caspar I. van der Made, Machiel H. Jansen, Judy Geissler, J.M. (Merlijn) van den Berg, Martijn van der Kuip, Mariken P. Gruppen, Dieneke Schonenberg-Meinema, Berber Kapitein, A.M. (Marceline) Tutu van Furth, Sietse Q. Nagelkerke, Dasja Pajkrt, Frans B. Plötz, M.E.J. (Lisette) den Boer, Gijs W. Landman, Marlies A. van Houten, Ines
Publié dans: eBioMedicine, Numéro 95, 2023, Page(s) 104736, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104736

Mucoricin binding to β-glucan sites on germinating Mucorales spores disrupts neutrophil swarming to promote pathogenicity

Auteurs: Stavroula Baimpa, Matthaios Sertedakis, Elias Drakos, Tonia Akoumianaki, Alexandra Vatikioti, Yiyou Gu, Sanam Dolati, Anastasios Koutsopoulos, Ashraf S. Ibrahim, Georgios Chamilos
Publié dans: bioRxiv, Numéro October 29, 2026, ISSN 2692-8205
Éditeur: openRxiv
DOI: 10.1101/2025.10.28.685056

Alpha1-antitrypsin impacts innate host–pathogen interactions with Candida albicans by stimulating fungal filamentation

Auteurs: Martin Jaeger; Axel Dietschmann; Sophie Austermeier; Sude Dinçer; Pauline Porschitz; Larsen Vornholz; Ralph J.A. Maas; Evelien G.G. Sprenkeler; Jürgen Ruland; Stefan Wirtz; Tania Azam; Leo A.B. Joosten; Bernhard Hube; Mihai G. Netea; Charles A. Dinarello; Mark S. Gresnigt
Publié dans: Virulence, 15, 1, pp. 2333367, Numéro 9, 2024, ISSN 2150-5594
Éditeur: Landes Bioscience
DOI: 10.1080/21505594.2024.2333367

Bacteria and fungi of the lung: allies or enemies?

Auteurs: Enrico Garaci, Marilena Pariano, Emilia Nunzi, Claudio Costantini, Marina Maria Bellet, Cinzia Antognelli, Matteo Antonio Russo, Luigina Romani
Publié dans: Frontiers in Pharmacology, Numéro 15, 2024, Page(s) 1497173, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1497173

Targeting immunometabolism in host-directed therapies to fungal disease

Auteurs: Gonçalves SM, Ferreira AV, Cunha C, Carvalho A
Publié dans: Clinical Experimental Immunology, Numéro Jun 11;208(2), 2022, Page(s) 158-166., ISSN 1365-2249
Éditeur: Oxford Academic
DOI: 10.1093/cei/uxab014

Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

Auteurs: 53. Farnaz Daneshnia, Liuyang Cai, Deepika Gunasekaran, Isha Gautam, Austin Perry, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Julieta Munoz, Dorian Padilla, Süleyha Hilmioglu-Polat, Shenglin Mei, Daniel J. Floyd, Miquel Àngel Schikora-Tamarit, Diego Funtes, Maria Artigués-Lleixà, Louise Walker, Samuel M. Gonçalves, Mostafa Salehi, Agostinho Carvalho, Jigar V. DesaiDavid S. Perlin, Carol Munr
Publié dans: Microbiology spectrum, Numéro in press, 2025, ISSN 2165-0497
Éditeur: the American Society for Microbiology

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

Auteurs: Christophe d'Enfert, Ann-Kristin Kaune, Leovigildo-Rey Alaban, Sayoni Chakraborty, Nathaniel Cole, Margot Delavy, Daria Kosmala, Benoît Marsaux, Ricardo Fróis-Martins, Moran Morelli, Diletta Rosati, Marisa Valentine, Zixuan Xie, Yoan Emritloll, Peter A Warn, Frédéric Bequet, Marie-Elisabeth Bougnoux, Stephanie Bornes, Mark S Gresnigt, Bernhard Hube, Ilse D Jacobsen, Mélanie Legrand, Salomé L
Publié dans: FEMS Microbiology Reviews, Numéro 45/3, 2020, Page(s) fuaa060, ISSN 1574-6976
Éditeur: -
DOI: 10.1093/femsre/fuaa060

Microbiota-derived metabolites as diagnostic markers for respiratory fungal infections

Auteurs: Anaїs Hérivaux, Samuel M. Gonçalves, Agostinho Carvalho, Cristina Cunha
Publié dans: Journal of Pharmaceutical and Biomedical Analysis, Numéro 189, 2020, Page(s) 113473, ISSN 0731-7085
Éditeur: Elsevier BV
DOI: 10.1016/j.jpba.2020.113473

The development of single-domain VHH nanobodies that target the Candida albicans cell surface

Auteurs: Giuseppe Buda De Cesare, Frank M. Sauer, Anna Kolecka, Aimilia A. Stavrou, Theo C. Verrips, Teun Boekhout, Edward Dolk, Carol A. Munro
Publié dans: Microbiology Spectrum, Numéro 12, 2024, Page(s) e0426923, ISSN 2165-0497
Éditeur: American Society for Microbiology
DOI: 10.1128/spectrum.04269-23

Functional Lipid Analysis via Index-Based Lipidomics Profile: A New Computational Module in LipidOne

Auteurs: H. B. R. Alabed, D. F. Mancini, M. Pergola, L. Romani, S. Martino, A. Koulman, R. M. Pellegrino
Publié dans: bioRxiv, Numéro in press, 2026, ISSN 2692-8205
Éditeur: openRxiv
DOI: 10.1101/2025.11.04.686489

Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients

Auteurs: Anaïs Hérivaux, Jesse R Willis, Toine Mercier, Katrien Lagrou, Samuel M Gonçalves, Relber A Gonçales, Johan Maertens, Agostinho Carvalho, Toni Gabaldón, Cristina Cunha
Publié dans: Thorax, 2021, Page(s) thoraxjnl-2020-216179, ISSN 0040-6376
Éditeur: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2020-216179

Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism

Auteurs: Barbara Cellini, Teresa Zelante, Mirco Dindo, Marina M. Bellet, Giorgia Renga, Luigina Romani, Claudio Costantini
Publié dans: International Journal of Molecular Sciences, Numéro 21/16, 2020, Page(s) 5823, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165823

Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis

Auteurs: Matzaraki V, Beno A, Jaeger M, Gresnigt MS, Keur N, Boahen C, Cunha C, Gonçalves SM, Leite L, Lacerda JF, Campos A Jr, van de Veerdonk FL, Joosten L, Netea MG, Carvalho A, Kumar V
Publié dans: Redox Biology, Numéro Jul 4;55:, 2022, Page(s) 102391
Éditeur: Elsevier
DOI: 10.1016/j.redox.2022.102391

COVID-19-associated fungal infections

Auteurs: Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, Ibrahim AS, Carvalho A
Publié dans: Nature Microbiology, Numéro Aug;7(8), 2022, Page(s) 1127-1140, ISSN 2058-5276
Éditeur: Nature Springer
DOI: 10.1038/s41564-022-01172-2

Future Prospects and Challenges in Mucormycosis Research

Auteurs: Georgios Chamilos, Ulrike Binder, Victoriano Garre
Publié dans: Journal of Fungi, Numéro 11, 2025, Page(s) 545, ISSN 2309-608X
Éditeur: MDPI AG
DOI: 10.3390/jof11080545

A Functional Polymorphism in IL-36β Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis

Auteurs: Samuel M Gonçalves, Luis Leite, Pedro de Vasconcelos, Inês Pereira, Intan M W Dewi, Toine Mercier, Robina Aerts, Dário Ligeiro, Filomena Mendes, Fátima Freitas, Jorge Condeço, Joana Vieira, Eduardo Espada, Katrien Lagrou, Johan A Maertens, Mark S Gresnigt, Charles A Dinarello, João F Lacerda, Carlos Pinho Vaz, Cristina Cunha, Agostinho Carvalho, Frank L van de Veerdonk
Publié dans: The Journal of Infectious Diseases, Numéro 232, 2025, Page(s) 1208-1219, ISSN 0022-1899
Éditeur: University of Chicago Press
DOI: 10.1093/infdis/jiaf301

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

Auteurs: de Castro PA, Colabardini AC, Moraes M, Horta MAC, Knowles SL, Raja HA, Oberlies NH, Koyama Y, Ogawa M, Gomi K, Steenwyk JL, Rokas A, Gonçales RA, Duarte-Oliveira C, Carvalho A, Ries LNA, Goldman GH
Publié dans: PLoS Genetics, Numéro Jan;18(1), 2022, Page(s) e1009965, ISSN 1553-7390
Éditeur: Public Library of Science
DOI: 10.1371/journal.pgen.1009965

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity

Auteurs: Ries LNA, Alves de Castro P, Pereira Silva L, Valero C, Dos Reis TF, Saborano R, Duarte IF, Persinoti GF, Steenwyk JL, Rokas A, Almeida F, Costa JH, Fill T, Sze Wah Wong S, Aimanianda V, Rodrigues FJS
Publié dans: mBio, Numéro Aug 31;12(4), 2021, Page(s) e0168221
Éditeur: American Society of Microbiology
DOI: 10.1128/mbio.01682-21

The immune and microbial homeostasis determines the Candida-mast cells cross-talk in celiac disease

Auteurs: Giorgia Renga, Marilena Pariano, Fiorella D'Onofrio, Giuseppe Pieraccini, Claudia Di Serio, Valeria Rachela Villella, Carlo Abbate, Matteo Puccetti , Stefano Giovagnoli, Claudia Stincardini, Marina Maria Bellet, Maurizio Ricci, Claudio Costantini, Vasileios Oikonomou, Luigina Romani.
Publié dans: Life Sci Alliance, Numéro 7, 2024, Page(s) e202302441, ISSN 2575-1077
Éditeur: -
DOI: 10.26508/lsa.202302441

A shifted composition of the lung microbiota conditions the antifungal response of immunodeficient mice

Auteurs: Emilia Nunzi, Giorgia Renga, Melissa Palmieri, Giuseppe Pieraccini, Marilena Pariano, Claudia Stincardini, Fiorella D’Onofrio, Ilaria Santarelli, Marina Maria Bellet, Andrea Bartoli, Claudio Costantini, Luigina Romani
Publié dans: International Journal of Molecular Sciences, Numéro Aug 6;22(16), 2021, Page(s) 8474, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22168474

sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID

Auteurs: Lisa Hurler, Federica Mescia, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka, Paul A. Lyons, and Erik J.M. Toonen.
Publié dans: iScience., Numéro VOLUME 27, ISSUE 7, 2024, Page(s) 110162, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/j.isci.2024.110162

Paracoccin Overexpression in Paracoccidioides brasiliensis Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall

Auteurs: Gonçales RA, Ricci-Azevedo R, Vieira VCS, Fernandes FF, Thomaz SMO, Carvalho A, Vendruscolo PE, Cunha C, Roque-Barreira MC, Rodrigues F
Publié dans: Journal of Infectious Diseases, Numéro Jul 2;224(1), 2021, Page(s) 164-174, ISSN 1537-6613
Éditeur: Oxford Academic
DOI: 10.1093/infdis/jiaa707

Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis

Auteurs: Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CS, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A
Publié dans: American Journal of Respiratory and Critical Care Medicine, Numéro Nov 1;206(9):, 2022, Page(s) 1140-1152, ISSN 1073-449X
Éditeur: American Thoracic Society
DOI: 10.1164/rccm.202112-2771oc

Humoral pathways of innate immune regulation in granuloma formation

Auteurs: Santos-Ribeiro D, Cunha C, Carvalho A
Publié dans: Trends Immunol, Numéro 45(6), 2024, Page(s) 419-427
Éditeur: Cell Press
DOI: 10.1016/j.it.2024.04.008

From the nose to the lungs: the intricate journey of airborne pathogens amid commensal bacteria

Auteurs: Claudio Costantini, Emilia Nuinzi, Luigina Romani
Publié dans: American Physiological Society, Numéro Epub 2022 Aug 29, 2022, ISSN 1522-1563
Éditeur: American Physiological Society
DOI: 10.1152/ajpcell.00287.2022

'Mapping' Knowledge Dissemination

Auteurs: Nynke Bos, Lisa Vandeberg, Anke Oerlemans, Marlies Hulscher, W. Gudrun Reijnierse
Publié dans: European Journal of Health Communication, Numéro 6, 2025, Page(s) 60-82, ISSN 2673-5903
Éditeur: University of Zurich, IKMZ – Department of Communication and Media Research
DOI: 10.47368/ejhc.2025.103

Innovative Approaches to Medical Rehabilitation: Regeneration, Immune Training, Homeostasis, and Microbiome Synergy

Auteurs: Enrico Garaci, Matteo Antonio Russo, Marilena Pariano, Matteo Puccetti, Consuelo Fabi, Sarah Balucchi, Marina Maria Bellet, Maurizio Ricci, Massimo Fini, Luigina Romani
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, Page(s) 8687, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26178687

Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis

Auteurs: Laura Seldeslachts, Frederik Staels, Marina Gkountzinopoulou, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Lander De Herdt, Jeason Haughton, Teresa Prezzemolo, Oliver Burton, Simon Feys, Frank L. van de Veerdonk, Agostinho Carvalho, Lieve Naesens, Patrick Matthys, Katrien Lagrou, Erik Verbeken, Georgios Chamilos, Joost Wauters, Stephanie Humblet-Baron, Greetje Vande
Publié dans: eBioMedicine, Numéro 108, 2024, Page(s) 105347, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105347

Albumin Neutralizes Hydrophobic Toxins and Modulates Candida albicans Pathogenicity

Auteurs: Sophie Austermeier, Marina Pekmezović, Pauline Porschitz, Sejeong Lee, Nessim Kichik, David L. Moyes, Jemima Ho, Natalia K. Kotowicz, Julian R. Naglik, Bernhard Hube, Mark S. Gresnigt
Publié dans: mBio, Numéro -, 2021, Page(s) e0053121, ISSN 2150-7511
Éditeur: -
DOI: 10.1128/mbio.00531-21

Can metaphors in patient information materials improve comprehension and attitudes regarding innovative treatment? The case of personalized immunotherapy for sepsis

Auteurs: Nynke Bos, W. Gudrun Reijnierse, Anke J.M. Oerlemans, Frank L. van de Veerdonk, Mihai G. Netea, Marlies E.J.L. Hulscher, Lisa Vandeberg
Publié dans: Patient Education and Counseling, Numéro 141, 2026, Page(s) 109314, ISSN 0738-3991
Éditeur: Elsevier BV
DOI: 10.1016/j.pec.2025.109314

A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis

Auteurs: Simon Feys; Jannes Heylen; Agostinho Carvalho; Johan Van Weyenbergh; Joost Wauters; Samuel M. Gonçalves; Cristina Cunha; Yves Debaveye; Greet Hermans; Stephanie Humblet-Baron; Cato Jacobs; Diether La
Publié dans: Intensive Care Medicine, Numéro 49, 2023, Page(s) 2454-257
Éditeur: SPRINGER LINK
DOI: 10.1007/s00134-022-06958-w

Aspergillus fumigatus biology, immunopathogenicity and drug resistance

Auteurs: Frank L. van de Veerdonk, Agostinho Carvalho, Joost Wauters, George Chamilos, Paul E. Verweij
Publié dans: Nature Reviews Microbiology, Numéro 23, 2025, Page(s) 652-666, ISSN 1740-1526
Éditeur: Nature Publishing Group
DOI: 10.1038/s41579-025-01180-z

Editorial: Lung microbiome in health and disease

Auteurs: Kurtis Francis Budden, Luigina Romani
Publié dans: Frontiers in Pharmacology, Numéro 16, 2025, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1565849

Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response

Auteurs: Delavy, Margot; Sertour, Natacha; Patin, Etienne; Le Chatelier, Emmanuelle; Cole, Nathaniel; Dubois, Florian; Xie, Zixuan; Saint-André, Violaine; Manichanh, Chaysavanh; Walker, Alan; Quintana-Murci, Lluis; Duffy, Darragh; d'Enfert, Christophe; Bougnoux, Marie-Elisabeth; Consortium, Milieu Intérieur
Publié dans: Gut Microbes, Numéro 13, 2023, Page(s) 15(2): 22876, ISSN 1949-0984
Éditeur: -
DOI: 10.1080/19490976.2023.2287618

Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

Auteurs: Samuel M. Gonçalves, Daniela Antunes, Luis Leite, Toine Mercier, Rob ter Horst, Joana Vieira, Eduardo Espada, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Antón
Publié dans: mBio, Numéro -, 2021, Page(s) Online ahead of print, ISSN 2150-7511
Éditeur: -
DOI: 10.1128/mbio.00369-21

Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis

Auteurs: Laura Seldeslachts, Sirima Kraisin, Intan M. W. Dewi, Simon Feys, Frederik Staels, Marina Gkountzinopoulou, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Lander De Herdt, Oswin Kwan, Niels Vandamme, Jana Roels, Julika Neumann, Teresa Prezzemolo, Bert Malengier-Devlies, Mathias Stroobants, Agostinho Carvalho, Patrick Matthys, Lieve Naesens, Katrien Lagrou, Mona Khan,
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Éditeur: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adw9578

Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis

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Publié dans: Cell Host & Microbe, Numéro S1931-3128(21)00280-8., 2021, ISSN 1931-3128
Éditeur: Cell Press
DOI: 10.1016/j.chom.2021.06.002

Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities

Auteurs: Rita Silva-Gomes, Inês Caldeira, Raquel Fernandes, Cristina Cunha, Agostinho Carvalho
Publié dans: Journal of Leukocyte Biology, Numéro 116, 2024, Page(s) 469-486, ISSN 1938-3673
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/jleuko/qiae045

SARS-CoV-2 Infection is Associated with Age- and Gender-Specific Changes in the Nasopharyngeal Microbiome

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Publié dans: Front Biosci, 2024, Page(s) 29:59, ISSN 1093-9946
Éditeur: Frontiers in Bioscience
DOI: 10.31083/j.fbl2902059

A High-Risk Profile for Invasive Fungal Infections Is Associatedwith Altered Nasal Microbiota and Niche Determinants

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Publié dans: American Society for Microbiology, Numéro Apr 21;90(4), 2022, Page(s) e0004822, ISSN 1098-5522
Éditeur: American Society for Microbiology
DOI: 10.1128/iai.00048-22

Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway

Auteurs: Sophia U. J. Hitzler, Candela Fernández-Fernández, Kerstin Günther, Axel Dietschmann, Hrant Hovhannisyan, Anna Möslinger, Sophie Austermeier, Beatriz Cristóvão, Gianluca Vascelli, Teresa Zelante, Marina Pekmezović, Bernardo Ramírez-Zavala, Joachim Morschhäuser, Oliver Werz, Toni Gabaldón, Paul M. Jordan, Slavena Vylkova, Mark S. Gresnigt
Publié dans: Nature Communications, Numéro 16, 2025, Page(s) 6447, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-025-61701-5

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

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Publié dans: Nature Communications, Numéro 12/1, 2021, Page(s) 3739, ISSN 2041-1723
Éditeur: Nature Publishing Group
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A synthetic peptide mimic kills Candida albicans and synergistically prevents infection

Auteurs: Sebastian Schaefer, Raghav Vij, Jakob L. Sprague, Sophie Austermeier, Hue Dinh, Peter R. Judzewitsch, Sven Müller-Loennies, Taynara Lopes Silva, Eric Seemann, Britta Qualmann, Christian Hertweck, Kirstin Scherlach, Thomas Gutsmann, Amy K. Cain, Nathaniel Corrigan, Mark S. Gresnigt, Cyrille Boyer, Megan D. Lenardon, Sascha Brunke
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Éditeur: Nature Publishing Group
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Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis

Auteurs: Gonçalves SM, Pereira I, Feys S, Cunha C, Chamilos G, Hoenigl M, Wauters J, van de Veerdonk FL, Carvalho A
Publié dans: mBio, Numéro 15(6), 2024, Page(s) e0198223, ISSN 2150-7511
Éditeur: Washington, D.C. American Society for Microbiology
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Albumin orchestrates a natural host defense mechanism against mucormycosis

Auteurs: Antonis Pikoulas, Ioannis Morianos, Vassilis Nidris Nidris, Rania Hamdy, Ángeles López-López, Maria Moran-Garrido, Valliappan Muthu, Maria Halabalaki, Maria Papadovasilaki, Kyrmizi Irene, Yiyou Gu, Robina Aerts, Toine Mercier, Yuri Vanbiervliet, Sung-Yeon Cho, Amy Spallone, Dimitrios Samonakis, Efstathios Kastritis, Elias Drakos, Maria Tzardi, Aristides Eliopoulos, Konstantina Georgila, Agostin
Publié dans: Res Sq (preprint), Numéro Dec 3:rs.3.rs-5441197, 2026, ISSN 2693-5015
Éditeur: Springer Science and Business Media LLC
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Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis

Auteurs: Feys S, Cardinali-Benigni M, Lauwers HM, Jacobs C, Stevaert A, Gonçalves SM, Cunha C, Debaveye Y, Hermans G, Heylen J, Humblet-Baron S, Lagrou K, Maessen L, Meersseman P, Peetermans M, Redondo-Rios A, Seldeslachts L, Starick MR, Thevissen K, Vande Velde G, Vandenbriele C, Vanderbeke L, Wilmer A, Naesens L, van de Veerdonk FL, Van Weyenbergh J, Gabaldón T, Wauters J, Carvalho A.
Publié dans: American Journal of Respiratory and Critical Care Medicine, Numéro Epub ahead of print, 2024, ISSN 1073-449X
Éditeur: American Thoracic Society
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In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

Auteurs: Zoe K. Ross, Sakinah Alsayegh, Yixin Zhao, Steven McPherson, Carol A. Munro, Alexander Lorenz
Publié dans: Microbiological Research, Numéro 301, 2026, Page(s) 128322, ISSN 0944-5013
Éditeur: Elsevier BV
DOI: 10.1016/j.micres.2025.128322

Editorial: Advancements in the understanding of Mucorales biology and the management of mucormycosis

Auteurs: Georgios Chamilos, Victoriano Garre
Publié dans: Frontiers in Cellular and Infection Microbiology, Numéro 14, 2024, Page(s) 1427252, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2024.1427252

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