Host directed medicine in invasive fungal infection

Risultati finali

Report on journalistic and scientific immunotherapy narratives

An analysis will be performed of the Englishlanguage journalistic and scientific discourse surrounding immunotherapy for infections

Development of project website and project visual identity

Development of a project website and of a logo that visually identifies the project and allow people to recognise the HDMFUN message at the first glance

Pubblicazioni

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Autori: imon Feys, MD Samuel M Gonçalves, MSc * Mona Khan, PhD * Sumin Choi, MSc * Bram Boeckx, PhD Denis Chatelain, MD Cristina Cunha, PhD Yves Debaveye, MD Prof Greet Hermans, MD Marjan Hertoghs, MD Stephanie Humblet-Baron, MD Cato Jacobs, MSc Prof Katrien Lagrou, PhD Lukas Marcelis, MD Prof Julien Maizel, MD Philippe Meersseman, MD Rémy Nyga, MD Laura Seldeslachts, MSc Marick Rodrigues Starick, MSc K
Pubblicato in: The Lancet Respiratory Medicine, Numero monthly, 2022, Pagina/e P1147-1159
Editore: Elsevier
DOI: 10.1016/s2213-2600(22)00259-4

Rapidly expanded partially HLA DRB1–matched fungus-specific T cells mediate in vitro and in vivo antifungal activity

Autori: Gloria Castellano-González, Helen M. McGuire, Fabio Luciani, Leighton E. Clancy, Ziduo Li, Selmir Avdic, Brendan Hughes, Mandeep Singh, Barbara Fazekas de St Groth, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Luigina Romani, David J. Gottlieb
Pubblicato in: Blood Advances, Numero 4/14, 2020, Pagina/e 3443-3456, ISSN 2473-9529
Editore: Europe PMC
DOI: 10.1182/bloodadvances.2020001565

Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation

Autori: da Silva-Ferreira S, Duarte-Oliveira C, Antunes D, Barbosa-Matos C, Mendes-Frias A, Torrado E, Costa S, Silvestre R, Cunha C, Carvalho A
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 12, 2022, Pagina/e 1005839, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.1005839

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

Autori: Jose Manuel Sánchez-Maldonado, Ana Moñiz-Díez, Rob ter Horst, Daniele Campa, Antonio José Cabrera-Serrano, Manuel Martínez-Bueno, María del Pilar Garrido-Collado, Francisca Hernández-Mohedo, Laura Fernández-Puerta, Miguel Ángel López-Nevot, Cristina Cunha, Pedro Antonio González-Sierra, Jan Springer, Michaela Lackner, Laura Alcazar-Fuoli, Luana Fianchi, José María Aguado, Livio Pagano
Pubblicato in: Journal of Fungi, Numero 7/1, 2021, Pagina/e 4, ISSN 2309-608X
Editore: -
DOI: 10.3390/jof7010004

The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19

Autori: Arianna Di Stadio, Claudio Costantini, Giorgia Renga, Marilena Pariano, Giampietro Ricci, Luigina Romani
Pubblicato in: Life, Numero 10/12, 2020, Pagina/e 345, ISSN 2075-1729
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/life10120345

Aspergillus fumigatus and aspergillosis: From basics to clinics

Autori: Arastehfar A, Carvalho A, Houbraken J, Lombardi L, Garcia-Rubio R, Jenks JD, Rivero-Menendez O, Aljohani R, Jacobsen ID, Berman J, Osherov N, Hedayati MT, Ilkit M, Armstrong-James D, Gabaldón T, Meletiadis J, Kostrzewa M, Pan W, Lass-Flörl C, Perlin DS, Hoenigl M
Pubblicato in: Studies in Mycology, Numero May 10;100, 2021, Pagina/e 100115
Editore: Westerdijk Fungal Biodiversity Institute
DOI: 10.1016/j.simyco.2021.100115

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

Autori: Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A, Gangneux JP, Nasir N, Bonifaz A, Araiza J, Klimko N, Serris A, Lagrou K, Meis JF, Cornely OA, Perfect JR, White PL, Chakrabarti A
Pubblicato in: Lancet Microbe, Numero Jul;3(7), 2022, Pagina/e e543-e552, ISSN 2666-5247
Editore: Elsevier
DOI: 10.1016/s2666-5247(21)00237-8

Targeting immunometabolism in host-directed therapies to fungal disease

Autori: Gonçalves SM, Ferreira AV, Cunha C, Carvalho A
Pubblicato in: Clinical Experimental Immunology, Numero Jun 11;208(2), 2022, Pagina/e 158-166., ISSN 1365-2249
Editore: Oxford Academic
DOI: 10.1093/cei/uxab014

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

Autori: Christophe d'Enfert, Ann-Kristin Kaune, Leovigildo-Rey Alaban, Sayoni Chakraborty, Nathaniel Cole, Margot Delavy, Daria Kosmala, Benoît Marsaux, Ricardo Fróis-Martins, Moran Morelli, Diletta Rosati, Marisa Valentine, Zixuan Xie, Yoan Emritloll, Peter A Warn, Frédéric Bequet, Marie-Elisabeth Bougnoux, Stephanie Bornes, Mark S Gresnigt, Bernhard Hube, Ilse D Jacobsen, Mélanie Legrand, Salomé L
Pubblicato in: FEMS Microbiology Reviews, Numero 45/3, 2020, Pagina/e fuaa060, ISSN 1574-6976
Editore: -
DOI: 10.1093/femsre/fuaa060

Microbiota-derived metabolites as diagnostic markers for respiratory fungal infections

Autori: Anaїs Hérivaux, Samuel M. Gonçalves, Agostinho Carvalho, Cristina Cunha
Pubblicato in: Journal of Pharmaceutical and Biomedical Analysis, Numero 189, 2020, Pagina/e 113473, ISSN 0731-7085
Editore: Elsevier BV
DOI: 10.1016/j.jpba.2020.113473

Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients

Autori: Anaïs Hérivaux, Jesse R Willis, Toine Mercier, Katrien Lagrou, Samuel M Gonçalves, Relber A Gonçales, Johan Maertens, Agostinho Carvalho, Toni Gabaldón, Cristina Cunha
Pubblicato in: Thorax, 2021, Pagina/e thoraxjnl-2020-216179, ISSN 0040-6376
Editore: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2020-216179

Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism

Autori: Barbara Cellini, Teresa Zelante, Mirco Dindo, Marina M. Bellet, Giorgia Renga, Luigina Romani, Claudio Costantini
Pubblicato in: International Journal of Molecular Sciences, Numero 21/16, 2020, Pagina/e 5823, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165823

Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis

Autori: Matzaraki V, Beno A, Jaeger M, Gresnigt MS, Keur N, Boahen C, Cunha C, Gonçalves SM, Leite L, Lacerda JF, Campos A Jr, van de Veerdonk FL, Joosten L, Netea MG, Carvalho A, Kumar V
Pubblicato in: Redox Biology, Numero Jul 4;55:, 2022, Pagina/e 102391
Editore: Elsevier
DOI: 10.1016/j.redox.2022.102391

COVID-19-associated fungal infections

Autori: Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, Ibrahim AS, Carvalho A
Pubblicato in: Nature Microbiology, Numero Aug;7(8), 2022, Pagina/e 1127-1140, ISSN 2058-5276
Editore: Nature Springer
DOI: 10.1038/s41564-022-01172-2

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

Autori: de Castro PA, Colabardini AC, Moraes M, Horta MAC, Knowles SL, Raja HA, Oberlies NH, Koyama Y, Ogawa M, Gomi K, Steenwyk JL, Rokas A, Gonçales RA, Duarte-Oliveira C, Carvalho A, Ries LNA, Goldman GH
Pubblicato in: PLoS Genetics, Numero Jan;18(1), 2022, Pagina/e e1009965, ISSN 1553-7390
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1009965

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity

Autori: Ries LNA, Alves de Castro P, Pereira Silva L, Valero C, Dos Reis TF, Saborano R, Duarte IF, Persinoti GF, Steenwyk JL, Rokas A, Almeida F, Costa JH, Fill T, Sze Wah Wong S, Aimanianda V, Rodrigues FJS, Gonçales RA, Duarte-Oliveira C, Carvalho A, Goldman GH
Pubblicato in: mBio, Numero Aug 31;12(4), 2021, Pagina/e e0168221
Editore: American Society of Microbiology
DOI: 10.1128/mbio.01682-21

A shifted composition of the lung microbiota conditions the antifungal response of immunodeficient mice

Autori: Emilia Nunzi, Giorgia Renga, Melissa Palmieri, Giuseppe Pieraccini, Marilena Pariano, Claudia Stincardini, Fiorella D’Onofrio, Ilaria Santarelli, Marina Maria Bellet, Andrea Bartoli, Claudio Costantini, Luigina Romani
Pubblicato in: International Journal of Molecular Sciences, Numero Aug 6;22(16), 2021, Pagina/e 8474, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22168474

Paracoccin Overexpression in Paracoccidioides brasiliensis Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall

Autori: Gonçales RA, Ricci-Azevedo R, Vieira VCS, Fernandes FF, Thomaz SMO, Carvalho A, Vendruscolo PE, Cunha C, Roque-Barreira MC, Rodrigues F
Pubblicato in: Journal of Infectious Diseases, Numero Jul 2;224(1), 2021, Pagina/e 164-174, ISSN 1537-6613
Editore: Oxford Academic
DOI: 10.1093/infdis/jiaa707

Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis

Autori: Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CS, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A
Pubblicato in: American Journal of Respiratory and Critical Care Medicine, Numero Nov 1;206(9):, 2022, Pagina/e 1140-1152, ISSN 1073-449X
Editore: American Thoracic Society
DOI: 10.1164/rccm.202112-2771oc

From the nose to the lungs: the intricate journey of airborne pathogens amid commensal bacteria

Autori: Claudio Costantini, Emilia Nuinzi, Luigina Romani
Pubblicato in: American Physiological Society, Numero Epub 2022 Aug 29, 2022, ISSN 1522-1563
Editore: American Physiological Society
DOI: 10.1152/ajpcell.00287.2022

Albumin Neutralizes Hydrophobic Toxins and Modulates Candida albicans Pathogenicity

Autori: Sophie Austermeier, Marina Pekmezović, Pauline Porschitz, Sejeong Lee, Nessim Kichik, David L. Moyes, Jemima Ho, Natalia K. Kotowicz, Julian R. Naglik, Bernhard Hube, Mark S. Gresnigt
Pubblicato in: mBio, 2021, Pagina/e e0053121, ISSN 2150-7511
Editore: -
DOI: 10.1128/mbio.00531-21

Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

Autori: Samuel M. Gonçalves, Daniela Antunes, Luis Leite, Toine Mercier, Rob ter Horst, Joana Vieira, Eduardo Espada, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, António Marques, Frank L. van de Veerdonk, Leo A. B. Joosten, Katrien Lagrou, Johan Maertens, Mihai G. Netea, João F. Lacerda, António Campos, Cristina Cunha, Agostinho Carvalho
Pubblicato in: mBio, 2021, Pagina/e Online ahead of print, ISSN 2150-7511
Editore: -
DOI: 10.1128/mbio.00369-21

Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis

Autori: Tonia Akoumianaki, Katerina Vaporidi, Eleni Diamantaki, Frédéric Pène, Remi Beau, Mark S. Gresnigt, Marina Gkountzinopulou, Maria Venichaki, Elias Drakos, Jamel El-Benna, George Samonis, Kieu T.T. Le, Vinod Kumar, Dimitrios Georgopoulos, Frank L. van de Veerdonk, Mihai G. Netea, Jean-Paul Latge, Georgios Chamilos
Pubblicato in: Cell Host & Microbe, Numero S1931-3128(21)00280-8., 2021, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2021.06.002

A High-Risk Profile for Invasive Fungal Infections Is Associatedwith Altered Nasal Microbiota and Niche Determinants

Autori: Claudio Costantini, Emilia Nunzi, Angelica Spolzino, Francesco Merli, Luca Facchini, Antonio Spadea, Lorella Melillo, Katia Codeluppi, Francesco Marchesi, Gessica Marchesini, Daniela Valente, Giulia Dragonetti, Gianpaolo Nadali, Lukas Englmaier, Katerina Coufalikova, Zdeněk Spáčil, Marina Maria Bellet, Marilena Pariano, Giorgia Renga, Claudia Stincardini, Fiorella D'Onofrio,
Pubblicato in: American Society for Microbiology, Numero Apr 21;90(4), 2022, Pagina/e e0004822, ISSN 1098-5522
Editore: American Society for Microbiology
DOI: 10.1128/iai.00048-22

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

Autori: Andrea Doni, Raffaella Parente, Ilaria Laface, Elena Magrini, Cristina Cunha, Federico Simone Colombo, João F. Lacerda, António Campos, Sarah N. Mapelli, Francesca Petroni, Rémi Porte, Tilo Schorn, Antonio Inforzato, Toine Mercier, Katrien Lagrou, Johan Maertens, John D. Lambris, Barbara Bottazzi, Cecilia Garlanda, Marina Botto, Agostinho Carvalho, Alberto Mantovani
Pubblicato in: Nature Communications, Numero 12/1, 2021, Pagina/e 3739, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24021-y

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