Host directed medicine in invasive fungal infection

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Report on journalistic and scientific immunotherapy narratives

An analysis will be performed of the Englishlanguage journalistic and scientific discourse surrounding immunotherapy for infections

Development of project website and project visual identity

Development of a project website and of a logo that visually identifies the project and allow people to recognise the HDMFUN message at the first glance

Pubblicazioni

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Autori: Simon Feys, MD Samuel M Gonçalves, MSc * Mona Khan, PhD * Sumin Choi, MSc * Bram Boeckx, PhD Denis Chatelain, MD Cristina Cunha, PhD Yves Debaveye, MD Prof Greet Hermans, MD Marjan Hertoghs, MD Steph
Pubblicato in: The Lancet Respiratory Medicine, Numero monthly, 2022, Pagina/e P1147-1159
Editore: Elsevier
DOI: 10.1016/s2213-2600(22)00259-4

Enteric delivery of indole-3-carboxylic acid unlocks therapeutic potential of postbiotic metabolite cascade

Autori: Matteo Puccetti, Marilena Pariano, Claudia Stincardini, Consuelo Fabi, Roberta Galarini, Carolina Barola, Husam Br. Alabed, Dorotea Frongia Mancini, Roberto Maria Pellegrino, Enrico Garaci, Maurizio Ricci, Luigina Romani, Stefano Giovagnoli
Pubblicato in: International Journal of Pharmaceutics, Numero 684, 2025, Pagina/e 126158, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.126158

Rapidly expanded partially HLA DRB1–matched fungus-specific T cells mediate in vitro and in vivo antifungal activity

Autori: Gloria Castellano-González, Helen M. McGuire, Fabio Luciani, Leighton E. Clancy, Ziduo Li, Selmir Avdic, Brendan Hughes, Mandeep Singh, Barbara Fazekas de St Groth, Giorgia Renga, Marilena Pariano, Marina M. Bellet, Luigina Romani, David J. Gottlieb
Pubblicato in: Blood Advances, Numero 4/14, 2020, Pagina/e 3443-3456, ISSN 2473-9529
Editore: Europe PMC
DOI: 10.1182/bloodadvances.2020001565

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway

Autori: Jia, Lei-Jie; Rafiq, Muhammad; Radosa, Lukáš; Hortschansky, Peter; Cunha, Cristina; Cseresnyés, Zoltán; Krüger, Thomas; Schmidt, Franziska; Heinekamp, Thorsten; Straßburger, Maria; Löffler, Bettina; Doenst, Torsten; Lacerda, João; Campos, António; Figge, Marc Thilo; Carvalho, Agostinho; Kniemeyer, Olaf; Brakhage, Axel A.
Pubblicato in: Cell Host Microb, Numero 31 (3), 2023, Pagina/e 16, ISSN 1934-6069
Editore: Cell Press
DOI: 10.1016/j.chom.2023.02.002

Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation

Autori: da Silva-Ferreira S, Duarte-Oliveira C, Antunes D, Barbosa-Matos C, Mendes-Frias A, Torrado E, Costa S, Silvestre R, Cunha C, Carvalho A
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 12, 2022, Pagina/e 1005839, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.1005839

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

Autori: Jose Manuel Sánchez-Maldonado, Ana Moñiz-Díez, Rob ter Horst, Daniele Campa, Antonio José Cabrera-Serrano, Manuel Martínez-Bueno, María del Pilar Garrido-Collado, Francisca Hernández-Mohedo, Laura Fernández-Puerta, Miguel Ángel López-Nevot, Cristina Cunha, Pedro Antonio González-Sierra, Jan Springer, Michaela Lackner, Laura Alcazar-Fuoli, Luana Fianchi, José María Aguado, Livio Pagano
Pubblicato in: Journal of Fungi, Numero 7/1, 2021, Pagina/e 4, ISSN 2309-608X
Editore: -
DOI: 10.3390/jof7010004

Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study.

Autori: Feys S, Vanmassenhove S, Kraisin S, Yu K, Jacobs C, Boeckx B, Cambier S, Cunha C, Debaveye Y, Gonçalves SM, Hermans G, Humblet-Baron S, Jansen S, Lagrou K, Meersseman P, Neyts J, Peetermans M, Rocha-
Pubblicato in: The Lancet Microbe., Numero 5(3), 2024, Pagina/e e247-e260.
Editore: Elsevier Ltd.
DOI: 10.1016/s2666-5247(23)00368-3

Harnessing inter-kingdom metabolic disparities at the human-fungal interface for novel therapeutic approaches.

Autori: Claudio Costantini, Marilena Pariano, Matteo Puccetti, Stefano Giovagnoli , Gioena Pampalone , Mirco Dindo , Barbara Cellini , Luigina Romani.
Pubblicato in: Front Mol Biosci, Numero 11, 2024, Pagina/e 1386598, ISSN 1746-2665
Editore: Frontiers
DOI: 10.3389/fmolb.2024.1386598

The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19

Autori: Arianna Di Stadio, Claudio Costantini, Giorgia Renga, Marilena Pariano, Giampietro Ricci, Luigina Romani
Pubblicato in: Life, Numero 10/12, 2020, Pagina/e 345, ISSN 2075-1729
Editore: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/life10120345

Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus

Autori: Daniela Antunes; Samuel M. Gonçalves; Vasiliki Matzaraki; Cláudia S. Rodrigues; Relber A. Gonçales; Joana Rocha; Jorge Sáiz; António Marques; Egídio Torrado; Ricardo Silvestre; Fernando Rodrigue
Pubblicato in: Microbiol Spectr, Numero 11(1), 2023, Pagina/e e0225622
Editore: American Society for Microbiology,
DOI: 10.1128/spectrum.02256-22

Aspergillus fumigatus and aspergillosis: From basics to clinics

Autori: Arastehfar A, Carvalho A, Houbraken J, Lombardi L, Garcia-Rubio R, Jenks JD, Rivero-Menendez O, Aljohani R, Jacobsen ID, Berman J, Osherov N, Hedayati MT, Ilkit M, Armstrong-James D, Gabaldón T, Mele
Pubblicato in: Studies in Mycology, Numero May 10;100, 2021, Pagina/e 100115
Editore: Westerdijk Fungal Biodiversity Institute
DOI: 10.1016/j.simyco.2021.100115

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

Autori: Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A, Gangneux JP, Nasir N, Bonifaz A, Araiza J, Klimko N, Serris A, Lagrou K, Meis JF, Cornely OA, Perfect JR, White PL, Chakrabarti A
Pubblicato in: Lancet Microbe, Numero Jul;3(7), 2022, Pagina/e e543-e552, ISSN 2666-5247
Editore: Elsevier
DOI: 10.1016/s2666-5247(21)00237-8

Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of disease

Autori: Stejara A. Netea, Giske Biesbroek, Diana van Stijn, Hanna Ijspeert, Caspar I. van der Made, Machiel H. Jansen, Judy Geissler, J.M. (Merlijn) van den Berg, Martijn van der Kuip, Mariken P. Gruppen, Dieneke Schonenberg-Meinema, Berber Kapitein, A.M. (Marceline) Tutu van Furth, Sietse Q. Nagelkerke, Dasja Pajkrt, Frans B. Plötz, M.E.J. (Lisette) den Boer, Gijs W. Landman, Marlies A. van Houten, Ines
Pubblicato in: eBioMedicine, Numero 95, 2023, Pagina/e 104736, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104736

Mucoricin binding to β-glucan sites on germinating Mucorales spores disrupts neutrophil swarming to promote pathogenicity

Autori: Stavroula Baimpa, Matthaios Sertedakis, Elias Drakos, Tonia Akoumianaki, Alexandra Vatikioti, Yiyou Gu, Sanam Dolati, Anastasios Koutsopoulos, Ashraf S. Ibrahim, Georgios Chamilos
Pubblicato in: bioRxiv, Numero October 29, 2026, ISSN 2692-8205
Editore: openRxiv
DOI: 10.1101/2025.10.28.685056

Alpha1-antitrypsin impacts innate host–pathogen interactions with Candida albicans by stimulating fungal filamentation

Autori: Martin Jaeger; Axel Dietschmann; Sophie Austermeier; Sude Dinçer; Pauline Porschitz; Larsen Vornholz; Ralph J.A. Maas; Evelien G.G. Sprenkeler; Jürgen Ruland; Stefan Wirtz; Tania Azam; Leo A.B. Joosten; Bernhard Hube; Mihai G. Netea; Charles A. Dinarello; Mark S. Gresnigt
Pubblicato in: Virulence, 15, 1, pp. 2333367, Numero 9, 2024, ISSN 2150-5594
Editore: Landes Bioscience
DOI: 10.1080/21505594.2024.2333367

Bacteria and fungi of the lung: allies or enemies?

Autori: Enrico Garaci, Marilena Pariano, Emilia Nunzi, Claudio Costantini, Marina Maria Bellet, Cinzia Antognelli, Matteo Antonio Russo, Luigina Romani
Pubblicato in: Frontiers in Pharmacology, Numero 15, 2024, Pagina/e 1497173, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1497173

Targeting immunometabolism in host-directed therapies to fungal disease

Autori: Gonçalves SM, Ferreira AV, Cunha C, Carvalho A
Pubblicato in: Clinical Experimental Immunology, Numero Jun 11;208(2), 2022, Pagina/e 158-166., ISSN 1365-2249
Editore: Oxford Academic
DOI: 10.1093/cei/uxab014

Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

Autori: 53. Farnaz Daneshnia, Liuyang Cai, Deepika Gunasekaran, Isha Gautam, Austin Perry, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Julieta Munoz, Dorian Padilla, Süleyha Hilmioglu-Polat, Shenglin Mei, Daniel J. Floyd, Miquel Àngel Schikora-Tamarit, Diego Funtes, Maria Artigués-Lleixà, Louise Walker, Samuel M. Gonçalves, Mostafa Salehi, Agostinho Carvalho, Jigar V. DesaiDavid S. Perlin, Carol Munr
Pubblicato in: Microbiology spectrum, Numero in press, 2025, ISSN 2165-0497
Editore: the American Society for Microbiology

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

Autori: Christophe d'Enfert, Ann-Kristin Kaune, Leovigildo-Rey Alaban, Sayoni Chakraborty, Nathaniel Cole, Margot Delavy, Daria Kosmala, Benoît Marsaux, Ricardo Fróis-Martins, Moran Morelli, Diletta Rosati, Marisa Valentine, Zixuan Xie, Yoan Emritloll, Peter A Warn, Frédéric Bequet, Marie-Elisabeth Bougnoux, Stephanie Bornes, Mark S Gresnigt, Bernhard Hube, Ilse D Jacobsen, Mélanie Legrand, Salomé L
Pubblicato in: FEMS Microbiology Reviews, Numero 45/3, 2020, Pagina/e fuaa060, ISSN 1574-6976
Editore: -
DOI: 10.1093/femsre/fuaa060

Microbiota-derived metabolites as diagnostic markers for respiratory fungal infections

Autori: Anaїs Hérivaux, Samuel M. Gonçalves, Agostinho Carvalho, Cristina Cunha
Pubblicato in: Journal of Pharmaceutical and Biomedical Analysis, Numero 189, 2020, Pagina/e 113473, ISSN 0731-7085
Editore: Elsevier BV
DOI: 10.1016/j.jpba.2020.113473

The development of single-domain VHH nanobodies that target the Candida albicans cell surface

Autori: Giuseppe Buda De Cesare, Frank M. Sauer, Anna Kolecka, Aimilia A. Stavrou, Theo C. Verrips, Teun Boekhout, Edward Dolk, Carol A. Munro
Pubblicato in: Microbiology Spectrum, Numero 12, 2024, Pagina/e e0426923, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/spectrum.04269-23

Functional Lipid Analysis via Index-Based Lipidomics Profile: A New Computational Module in LipidOne

Autori: H. B. R. Alabed, D. F. Mancini, M. Pergola, L. Romani, S. Martino, A. Koulman, R. M. Pellegrino
Pubblicato in: bioRxiv, Numero in press, 2026, ISSN 2692-8205
Editore: openRxiv
DOI: 10.1101/2025.11.04.686489

Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients

Autori: Anaïs Hérivaux, Jesse R Willis, Toine Mercier, Katrien Lagrou, Samuel M Gonçalves, Relber A Gonçales, Johan Maertens, Agostinho Carvalho, Toni Gabaldón, Cristina Cunha
Pubblicato in: Thorax, 2021, Pagina/e thoraxjnl-2020-216179, ISSN 0040-6376
Editore: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2020-216179

Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host–Microbe Tryptophan Metabolism

Autori: Barbara Cellini, Teresa Zelante, Mirco Dindo, Marina M. Bellet, Giorgia Renga, Luigina Romani, Claudio Costantini
Pubblicato in: International Journal of Molecular Sciences, Numero 21/16, 2020, Pagina/e 5823, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165823

Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis

Autori: Matzaraki V, Beno A, Jaeger M, Gresnigt MS, Keur N, Boahen C, Cunha C, Gonçalves SM, Leite L, Lacerda JF, Campos A Jr, van de Veerdonk FL, Joosten L, Netea MG, Carvalho A, Kumar V
Pubblicato in: Redox Biology, Numero Jul 4;55:, 2022, Pagina/e 102391
Editore: Elsevier
DOI: 10.1016/j.redox.2022.102391

COVID-19-associated fungal infections

Autori: Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, Ibrahim AS, Carvalho A
Pubblicato in: Nature Microbiology, Numero Aug;7(8), 2022, Pagina/e 1127-1140, ISSN 2058-5276
Editore: Nature Springer
DOI: 10.1038/s41564-022-01172-2

Future Prospects and Challenges in Mucormycosis Research

Autori: Georgios Chamilos, Ulrike Binder, Victoriano Garre
Pubblicato in: Journal of Fungi, Numero 11, 2025, Pagina/e 545, ISSN 2309-608X
Editore: MDPI AG
DOI: 10.3390/jof11080545

A Functional Polymorphism in IL-36β Modulates Macrophage Antifungal Effector Functions and Increases Susceptibility to Invasive Pulmonary Aspergillosis

Autori: Samuel M Gonçalves, Luis Leite, Pedro de Vasconcelos, Inês Pereira, Intan M W Dewi, Toine Mercier, Robina Aerts, Dário Ligeiro, Filomena Mendes, Fátima Freitas, Jorge Condeço, Joana Vieira, Eduardo Espada, Katrien Lagrou, Johan A Maertens, Mark S Gresnigt, Charles A Dinarello, João F Lacerda, Carlos Pinho Vaz, Cristina Cunha, Agostinho Carvalho, Frank L van de Veerdonk
Pubblicato in: The Journal of Infectious Diseases, Numero 232, 2025, Pagina/e 1208-1219, ISSN 0022-1899
Editore: University of Chicago Press
DOI: 10.1093/infdis/jiaf301

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

Autori: de Castro PA, Colabardini AC, Moraes M, Horta MAC, Knowles SL, Raja HA, Oberlies NH, Koyama Y, Ogawa M, Gomi K, Steenwyk JL, Rokas A, Gonçales RA, Duarte-Oliveira C, Carvalho A, Ries LNA, Goldman GH
Pubblicato in: PLoS Genetics, Numero Jan;18(1), 2022, Pagina/e e1009965, ISSN 1553-7390
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1009965

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity

Autori: Ries LNA, Alves de Castro P, Pereira Silva L, Valero C, Dos Reis TF, Saborano R, Duarte IF, Persinoti GF, Steenwyk JL, Rokas A, Almeida F, Costa JH, Fill T, Sze Wah Wong S, Aimanianda V, Rodrigues FJS
Pubblicato in: mBio, Numero Aug 31;12(4), 2021, Pagina/e e0168221
Editore: American Society of Microbiology
DOI: 10.1128/mbio.01682-21

The immune and microbial homeostasis determines the Candida-mast cells cross-talk in celiac disease

Autori: Giorgia Renga, Marilena Pariano, Fiorella D'Onofrio, Giuseppe Pieraccini, Claudia Di Serio, Valeria Rachela Villella, Carlo Abbate, Matteo Puccetti , Stefano Giovagnoli, Claudia Stincardini, Marina Maria Bellet, Maurizio Ricci, Claudio Costantini, Vasileios Oikonomou, Luigina Romani.
Pubblicato in: Life Sci Alliance, Numero 7, 2024, Pagina/e e202302441, ISSN 2575-1077
Editore: -
DOI: 10.26508/lsa.202302441

A shifted composition of the lung microbiota conditions the antifungal response of immunodeficient mice

Autori: Emilia Nunzi, Giorgia Renga, Melissa Palmieri, Giuseppe Pieraccini, Marilena Pariano, Claudia Stincardini, Fiorella D’Onofrio, Ilaria Santarelli, Marina Maria Bellet, Andrea Bartoli, Claudio Costantini, Luigina Romani
Pubblicato in: International Journal of Molecular Sciences, Numero Aug 6;22(16), 2021, Pagina/e 8474, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22168474

sMR and PTX3 levels associate with COVID-19 outcome and survival but not with Long COVID

Autori: Lisa Hurler, Federica Mescia, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Erika Kajdácsi, György Sinkovits, László Cervenak, Zoltán Prohászka, Paul A. Lyons, and Erik J.M. Toonen.
Pubblicato in: iScience., Numero VOLUME 27, ISSUE 7, 2024, Pagina/e 110162, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/j.isci.2024.110162

Paracoccin Overexpression in Paracoccidioides brasiliensis Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall

Autori: Gonçales RA, Ricci-Azevedo R, Vieira VCS, Fernandes FF, Thomaz SMO, Carvalho A, Vendruscolo PE, Cunha C, Roque-Barreira MC, Rodrigues F
Pubblicato in: Journal of Infectious Diseases, Numero Jul 2;224(1), 2021, Pagina/e 164-174, ISSN 1537-6613
Editore: Oxford Academic
DOI: 10.1093/infdis/jiaa707

Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis

Autori: Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Moura CS, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A
Pubblicato in: American Journal of Respiratory and Critical Care Medicine, Numero Nov 1;206(9):, 2022, Pagina/e 1140-1152, ISSN 1073-449X
Editore: American Thoracic Society
DOI: 10.1164/rccm.202112-2771oc

Humoral pathways of innate immune regulation in granuloma formation

Autori: Santos-Ribeiro D, Cunha C, Carvalho A
Pubblicato in: Trends Immunol, Numero 45(6), 2024, Pagina/e 419-427
Editore: Cell Press
DOI: 10.1016/j.it.2024.04.008

From the nose to the lungs: the intricate journey of airborne pathogens amid commensal bacteria

Autori: Claudio Costantini, Emilia Nuinzi, Luigina Romani
Pubblicato in: American Physiological Society, Numero Epub 2022 Aug 29, 2022, ISSN 1522-1563
Editore: American Physiological Society
DOI: 10.1152/ajpcell.00287.2022

'Mapping' Knowledge Dissemination

Autori: Nynke Bos, Lisa Vandeberg, Anke Oerlemans, Marlies Hulscher, W. Gudrun Reijnierse
Pubblicato in: European Journal of Health Communication, Numero 6, 2025, Pagina/e 60-82, ISSN 2673-5903
Editore: University of Zurich, IKMZ – Department of Communication and Media Research
DOI: 10.47368/ejhc.2025.103

Innovative Approaches to Medical Rehabilitation: Regeneration, Immune Training, Homeostasis, and Microbiome Synergy

Autori: Enrico Garaci, Matteo Antonio Russo, Marilena Pariano, Matteo Puccetti, Consuelo Fabi, Sarah Balucchi, Marina Maria Bellet, Maurizio Ricci, Massimo Fini, Luigina Romani
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, Pagina/e 8687, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26178687

Damping excessive viral-induced IFN-γ rescues the impaired anti-Aspergillus host immune response in influenza-associated pulmonary aspergillosis

Autori: Laura Seldeslachts, Frederik Staels, Marina Gkountzinopoulou, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Lander De Herdt, Jeason Haughton, Teresa Prezzemolo, Oliver Burton, Simon Feys, Frank L. van de Veerdonk, Agostinho Carvalho, Lieve Naesens, Patrick Matthys, Katrien Lagrou, Erik Verbeken, Georgios Chamilos, Joost Wauters, Stephanie Humblet-Baron, Greetje Vande
Pubblicato in: eBioMedicine, Numero 108, 2024, Pagina/e 105347, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2024.105347

Albumin Neutralizes Hydrophobic Toxins and Modulates Candida albicans Pathogenicity

Autori: Sophie Austermeier, Marina Pekmezović, Pauline Porschitz, Sejeong Lee, Nessim Kichik, David L. Moyes, Jemima Ho, Natalia K. Kotowicz, Julian R. Naglik, Bernhard Hube, Mark S. Gresnigt
Pubblicato in: mBio, Numero -, 2021, Pagina/e e0053121, ISSN 2150-7511
Editore: -
DOI: 10.1128/mbio.00531-21

Can metaphors in patient information materials improve comprehension and attitudes regarding innovative treatment? The case of personalized immunotherapy for sepsis

Autori: Nynke Bos, W. Gudrun Reijnierse, Anke J.M. Oerlemans, Frank L. van de Veerdonk, Mihai G. Netea, Marlies E.J.L. Hulscher, Lisa Vandeberg
Pubblicato in: Patient Education and Counseling, Numero 141, 2026, Pagina/e 109314, ISSN 0738-3991
Editore: Elsevier BV
DOI: 10.1016/j.pec.2025.109314

A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis

Autori: Simon Feys; Jannes Heylen; Agostinho Carvalho; Johan Van Weyenbergh; Joost Wauters; Samuel M. Gonçalves; Cristina Cunha; Yves Debaveye; Greet Hermans; Stephanie Humblet-Baron; Cato Jacobs; Diether La
Pubblicato in: Intensive Care Medicine, Numero 49, 2023, Pagina/e 2454-257
Editore: SPRINGER LINK
DOI: 10.1007/s00134-022-06958-w

Aspergillus fumigatus biology, immunopathogenicity and drug resistance

Autori: Frank L. van de Veerdonk, Agostinho Carvalho, Joost Wauters, George Chamilos, Paul E. Verweij
Pubblicato in: Nature Reviews Microbiology, Numero 23, 2025, Pagina/e 652-666, ISSN 1740-1526
Editore: Nature Publishing Group
DOI: 10.1038/s41579-025-01180-z

Editorial: Lung microbiome in health and disease

Autori: Kurtis Francis Budden, Luigina Romani
Pubblicato in: Frontiers in Pharmacology, Numero 16, 2025, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2025.1565849

Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response

Autori: Delavy, Margot; Sertour, Natacha; Patin, Etienne; Le Chatelier, Emmanuelle; Cole, Nathaniel; Dubois, Florian; Xie, Zixuan; Saint-André, Violaine; Manichanh, Chaysavanh; Walker, Alan; Quintana-Murci, Lluis; Duffy, Darragh; d'Enfert, Christophe; Bougnoux, Marie-Elisabeth; Consortium, Milieu Intérieur
Pubblicato in: Gut Microbes, Numero 13, 2023, Pagina/e 15(2): 22876, ISSN 1949-0984
Editore: -
DOI: 10.1080/19490976.2023.2287618

Genetic Variation in PFKFB3 Impairs Antifungal Immunometabolic Responses and Predisposes to Invasive Pulmonary Aspergillosis

Autori: Samuel M. Gonçalves, Daniela Antunes, Luis Leite, Toine Mercier, Rob ter Horst, Joana Vieira, Eduardo Espada, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Antón
Pubblicato in: mBio, Numero -, 2021, Pagina/e Online ahead of print, ISSN 2150-7511
Editore: -
DOI: 10.1128/mbio.00369-21

Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis

Autori: Laura Seldeslachts, Sirima Kraisin, Intan M. W. Dewi, Simon Feys, Frederik Staels, Marina Gkountzinopoulou, Cato Jacobs, Birger Tielemans, Eliane Vanhoffelen, Agustin Reséndiz-Sharpe, Lander De Herdt, Oswin Kwan, Niels Vandamme, Jana Roels, Julika Neumann, Teresa Prezzemolo, Bert Malengier-Devlies, Mathias Stroobants, Agostinho Carvalho, Patrick Matthys, Lieve Naesens, Katrien Lagrou, Mona Khan,
Pubblicato in: Science Translational Medicine, Numero 17, 2025, Pagina/e eadw9578, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.adw9578

Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis

Autori: Tonia Akoumianaki, Katerina Vaporidi, Eleni Diamantaki, Frédéric Pène, Remi Beau, Mark S. Gresnigt, Marina Gkountzinopulou, Maria Venichaki, Elias Drakos, Jamel El-Benna, George Samonis, Kieu T.T. Le, Vinod Kumar, Dimitrios Georgopoulos, Frank L. van de Veerdonk, Mihai G. Netea, Jean-Paul Latge, Georgios Chamilos
Pubblicato in: Cell Host & Microbe, Numero S1931-3128(21)00280-8., 2021, ISSN 1931-3128
Editore: Cell Press
DOI: 10.1016/j.chom.2021.06.002

Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities

Autori: Rita Silva-Gomes, Inês Caldeira, Raquel Fernandes, Cristina Cunha, Agostinho Carvalho
Pubblicato in: Journal of Leukocyte Biology, Numero 116, 2024, Pagina/e 469-486, ISSN 1938-3673
Editore: Oxford University Press (OUP)
DOI: 10.1093/jleuko/qiae045

SARS-CoV-2 Infection is Associated with Age- and Gender-Specific Changes in the Nasopharyngeal Microbiome

Autori: Silvia Bozza, Emilia Nunzi, Abel Frias-Mazuecos, Giuseppe Pieraccini , Marilena Pariano , Giorgia Renga, Antonella Mencacci, Vincenzo Nicola Talesa, Cinzia Antognelli, Paolo Puccetti, Luigina Romani, Claudio Costantini.
Pubblicato in: Front Biosci, 2024, Pagina/e 29:59, ISSN 1093-9946
Editore: Frontiers in Bioscience
DOI: 10.31083/j.fbl2902059

A High-Risk Profile for Invasive Fungal Infections Is Associatedwith Altered Nasal Microbiota and Niche Determinants

Autori: Claudio Costantini, Emilia Nunzi, Angelica Spolzino, Francesco Merli, Luca Facchini, Antonio Spadea, Lorella Melillo, Katia Codeluppi, Francesco Marchesi, Gessica Marchesini, Daniela Valente, Giulia Dragonetti, Gianpaolo Nadali, Lukas Englmaier, Katerina Coufalikova, Zdeněk Spáčil, Marina Maria Bellet, Marilena Pariano, Giorgia Renga, Claudia Stincardini, Fiorella D'Onofrio,
Pubblicato in: American Society for Microbiology, Numero Apr 21;90(4), 2022, Pagina/e e0004822, ISSN 1098-5522
Editore: American Society for Microbiology
DOI: 10.1128/iai.00048-22

Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway

Autori: Sophia U. J. Hitzler, Candela Fernández-Fernández, Kerstin Günther, Axel Dietschmann, Hrant Hovhannisyan, Anna Möslinger, Sophie Austermeier, Beatriz Cristóvão, Gianluca Vascelli, Teresa Zelante, Marina Pekmezović, Bernardo Ramírez-Zavala, Joachim Morschhäuser, Oliver Werz, Toni Gabaldón, Paul M. Jordan, Slavena Vylkova, Mark S. Gresnigt
Pubblicato in: Nature Communications, Numero 16, 2025, Pagina/e 6447, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-61701-5

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

Autori: Andrea Doni, Raffaella Parente, Ilaria Laface, Elena Magrini, Cristina Cunha, Federico Simone Colombo, João F. Lacerda, António Campos, Sarah N. Mapelli, Francesca Petroni, Rémi Porte, Tilo Schorn, Antonio Inforzato, Toine Mercier, Katrien Lagrou, Johan Maertens, John D. Lambris, Barbara Bottazzi, Cecilia Garlanda, Marina Botto, Agostinho Carvalho, Alberto Mantovani
Pubblicato in: Nature Communications, Numero 12/1, 2021, Pagina/e 3739, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-24021-y

A synthetic peptide mimic kills Candida albicans and synergistically prevents infection

Autori: Sebastian Schaefer, Raghav Vij, Jakob L. Sprague, Sophie Austermeier, Hue Dinh, Peter R. Judzewitsch, Sven Müller-Loennies, Taynara Lopes Silva, Eric Seemann, Britta Qualmann, Christian Hertweck, Kirstin Scherlach, Thomas Gutsmann, Amy K. Cain, Nathaniel Corrigan, Mark S. Gresnigt, Cyrille Boyer, Megan D. Lenardon, Sascha Brunke
Pubblicato in: Nature Communications, Numero 15, 2024, Pagina/e 6818, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-50491-x

Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis

Autori: Gonçalves SM, Pereira I, Feys S, Cunha C, Chamilos G, Hoenigl M, Wauters J, van de Veerdonk FL, Carvalho A
Pubblicato in: mBio, Numero 15(6), 2024, Pagina/e e0198223, ISSN 2150-7511
Editore: Washington, D.C. American Society for Microbiology
DOI: 10.1128/mbio.01982-23

Albumin orchestrates a natural host defense mechanism against mucormycosis

Autori: Antonis Pikoulas, Ioannis Morianos, Vassilis Nidris Nidris, Rania Hamdy, Ángeles López-López, Maria Moran-Garrido, Valliappan Muthu, Maria Halabalaki, Maria Papadovasilaki, Kyrmizi Irene, Yiyou Gu, Robina Aerts, Toine Mercier, Yuri Vanbiervliet, Sung-Yeon Cho, Amy Spallone, Dimitrios Samonakis, Efstathios Kastritis, Elias Drakos, Maria Tzardi, Aristides Eliopoulos, Konstantina Georgila, Agostin
Pubblicato in: Res Sq (preprint), Numero Dec 3:rs.3.rs-5441197, 2026, ISSN 2693-5015
Editore: Springer Science and Business Media LLC
DOI: 10.21203/rs.3.rs-5441197/v1

Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis

Autori: Feys S, Cardinali-Benigni M, Lauwers HM, Jacobs C, Stevaert A, Gonçalves SM, Cunha C, Debaveye Y, Hermans G, Heylen J, Humblet-Baron S, Lagrou K, Maessen L, Meersseman P, Peetermans M, Redondo-Rios A, Seldeslachts L, Starick MR, Thevissen K, Vande Velde G, Vandenbriele C, Vanderbeke L, Wilmer A, Naesens L, van de Veerdonk FL, Van Weyenbergh J, Gabaldón T, Wauters J, Carvalho A.
Pubblicato in: American Journal of Respiratory and Critical Care Medicine, Numero Epub ahead of print, 2024, ISSN 1073-449X
Editore: American Thoracic Society
DOI: 10.1164/rccm.202401-0145oc

In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

Autori: Zoe K. Ross, Sakinah Alsayegh, Yixin Zhao, Steven McPherson, Carol A. Munro, Alexander Lorenz
Pubblicato in: Microbiological Research, Numero 301, 2026, Pagina/e 128322, ISSN 0944-5013
Editore: Elsevier BV
DOI: 10.1016/j.micres.2025.128322

Editorial: Advancements in the understanding of Mucorales biology and the management of mucormycosis

Autori: Georgios Chamilos, Victoriano Garre
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 14, 2024, Pagina/e 1427252, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2024.1427252

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