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A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy in TB patients.

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Update of the Communication and Dissemination Plan No. 3 (opens in new window)

Communication and Dissemination Plan with updates included if needed.

Report on the clinical validation of relevant biomarkers and tests Final (opens in new window)

Report on the results of the study of host factors. Can be the related papers published.

List of relevant biomarkers (opens in new window)

List of the biomarkers identified within SMA-TB as relevant for the clinical outcome, the response to treatment or for other reasons.

Ethical Report No.3 (opens in new window)

Report on the Ethical issues

Report on the communication and dissemination activities No. 2 (opens in new window)

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period

Communication and Dissemination Plan (opens in new window)

Communication and Dissemination Plan drafted, approved and published.

Report on the communication and dissemination activities No. 3 (opens in new window)

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Update of the Communication and Dissemination Plan No. 1 (opens in new window)

Communication and Dissemination Plan with updates included if needed.

Uploading results in the study registry. (opens in new window)

Reporting the results in the study registry -public database. Can be the related papers issued.

Report on main findings of the project final workshop (opens in new window)

Report on main findings of the project final workshop, including the program and feedback.

Report on the study of host factors Final (opens in new window)

Report on the results of the study of host factors. Can be the related papers published.

Update of the Communication and Dissemination Plan No. 2 (opens in new window)

Communication and Dissemination Plan with updates included if needed

Ethical Report No.1 (opens in new window)

Report on the Ethical issues.

Report on the communication and dissemination activities No. 1 (opens in new window)

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Ethical Report No.4 (opens in new window)

Report on the Ethical issues.

Ethical Report Final (opens in new window)

Report on the Ethical issues.

Report on the study of pathogen factors Final (opens in new window)

Report on the performance and status of the host factors studied, including results if available.

Ethical Report No.2 (opens in new window)

Report on the Ethical issues

Stratification Algorithm (opens in new window)

Description of the algorithm able to predict patients’ clinical outcome and/or response to intervention to be used at clinical level to better manage patients and tailor treatment. Can be associated to a related paper published.

Project website (opens in new window)

Website online.

Sites capacity package (includes training documents and videos, working procedures and work flow infographics) Final (opens in new window)

Material needed for the good performance of the CT to be delivered to the sites (including protocols and training material).

Publications

Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic (opens in new window)

Author(s): Judith Farrés, José Luis Ruiz, José Manuel Mas, Lilibeth Arias, Maria-Rosa Sarrias, Carolina Armengol, Pere-Joan Cardona, José A. Muñoz-Moreno, Miriam Vilaplana, Belén Arranz, Judith Usall, Antoni Serrano-Blanco, Cristina Vilaplana
Published in: BMJ Open, Issue 11:e052140, 2021, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-052140

Multifaceted Roles of CD5L in Infectious and Sterile Inflammation (opens in new window)

Author(s): Lidia Sanchez-Moral, Neus Ràfols, Clara Martori, Tony Paul, Érica Téllez, Maria-Rosa Sarrias
Published in: International Journal of Molecular Sciences, Issue 22/8, 2021, Page(s) 4076, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084076

SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen (opens in new window)

Author(s): Lilibeth Arias, Kennedy Otwombe, Ziyaad Waja, Nestani Tukvadze, Tamta Korinteli, Tumelo Moloantoa, Kaori L Fonseca, Natasha Pillay, Thabiso Seiphetlo, Dan Ouchi-Vernet, Adrian Siles, Lidia Carabias, Carles Quiñones, Sergo Vashakidze, Neil Martinson & Cristina Vilaplana
Published in: Trials, 2023, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-023-07448-0

A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection (opens in new window)

Author(s): Sergio Fabián Mosquera-Restrepo, Sophie Zuberogoïtia, Lucie Gouxette, Emilie Layre, Martine Gilleron, Alexandre Stella, David Rengel, Odile Burlet-Schiltz, Ana Cecilia Caro, Luis F. Garcia, César Segura, Carlos Alberto Peláez Jaramillo, Mauricio Rojas & Jérôme Nigou
Published in: Nature Communications, Issue 14 December 2022, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35453-5

Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients (opens in new window)

Author(s): Marthe Jøntvedt Jørgensen, Kristin G. Nore, Hans Christian D. Aass, Emilie Layre, Jérôme Nigou, Rasmus Mortensen, Kjetil Tasken, Dag Kvale, Synne Jenum, Kristian Tonby, Anne Ma Dyrhol-Riise
Published in: Frontiers in Cellular and Infection Microbiology, Issue 11, 2021, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.669623

Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids (opens in new window)

Author(s): Margarida Correia-Neves, Jérôme Nigou, Zaynab Mousavian, Christopher Sundling and Gunilla Källenius
Published in: Frontiers in Immunology, Issue Front. Immunol., 02 December 2022, 2022, ISSN 1664-3224
Publisher: Frontiers in immunology
DOI: 10.3389/fimmu.2022.1035122

Macrophage CD5L is a target for cancer immunotherapy (opens in new window)

Author(s): Lidia Sanchez-Moral, Tony Paul, Clara Martori, Joan Font-Díaz, Lucía Sanjurjo, Gemma Aran, Érica Téllez, Julià Blanco, Jorge Carrillo, Masaoki Ito, Martina Tuttolomondo, Henrik J. Ditzel, Caterina Fumagalli, Gustavo Tapia, Julia Sidorova, Helena Masnou, Marco-Antonio Fernández-Sanmartín, Juan-José Lozano, Cristina Vilaplana, Alhelí Rodriguez-Cortés, Carolina Armengol, Annabel F. Valledor
Published in: eBioMedicine, Issue 91, 2024, Page(s) 104555, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104555

Exhaled breath specimens subjected to point-of-care lipoarabinomannan testing (opens in new window)

Author(s): F. Nabeemeeah, R. Sabet, T. Moloantoa, Z. Waja, Z. Pretorius, K. Majoro, M. Letutu-Xaba, C. Vilaplana, J. Nigou, N. Martinson
Published in: The International Journal of Tuberculosis and Lung Disease, Issue 27, 2023, Page(s) 703-705, ISSN 1027-3719
Publisher: International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories
DOI: 10.5588/ijtld.23.0128

Host‐directed therapy to combat mycobacterial infections* (opens in new window)

Author(s): Gül Kilinç, Anno Saris, Tom H. M. Ottenhoff, Mariëlle C. Haks
Published in: Immunological Reviews, Issue 301/1, 2021, Page(s) 62-83, ISSN 0105-2896
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imr.12951

Mycobacterium manresensis induces trained immunity in vitro (opens in new window)

Author(s): Miquel de Homdedeu, Lidia Sanchez-Moral, Concepció Violán, Neus Ràfols, Dan Ouchi, Berta Martín, Miguel A. Peinado, Alhelí Rodríguez-Cortés, Marta Arch-Sisquella, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Nuria Izquierdo-Useros, Betlem Salvador, Joan Matllo, Sergi López-Serrano, Joaquim Segalés, Cristina Vilaplana, Pere Torán-Monserrat, Rosa Morros, Ramon Monfà, Maria-Rosa Sarrias,
Published in: iScience, Issue 26, 2024, Page(s) 106873, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2023.106873

A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings (opens in new window)

Author(s): Arantxa Romero-Tamarit, Xavier Vallès, María Munar-García, Juan Espinosa-Pereiro, Núria Saborit, Ma. Teresa Tortola, Zoran Stojanovic, Sílvia Roure, Adrián Antuori, Pere-Joan Cardona, Antoni Soriano-Arandes, Andrea Martin-Nalda, María Espiau, Maria Luiza de Souza-Galvão, Ma. Ángeles Jiménez, Antoni Noguera-Julian, Israel Molina, Xavier Casas, Marisol Domínguez-Álvarez, Neus Jové, Nino
Published in: Infection, Issue 52, 2024, Page(s) 611-623, ISSN 0300-8126
Publisher: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02184-2

<scp>CD5L</scp> is upregulated upon infection with <i>Mycobacterium tuberculosis</i> with no effect on disease progression (opens in new window)

Author(s): Marcos S. Cardoso, Rute Gonçalves, Liliana Oliveira, Diogo Silvério, Érica Téllez, Tony Paul, Maria Rosa Sarrias, Alexandre M. Carmo, Margarida Saraiva
Published in: Immunology, 2024, ISSN 0019-2805
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/imm.13825

Disseminated tuberculosis and diagnosis delay during the COVID-19 era in a Western European country: a case series analysis (opens in new window)

Author(s): Sílvia Roure, Xavier Vallès, Nieves Sopena, Rosa Maria Benítez, Esteban A. Reynaga, Carmen Bracke, Cora Loste, Lourdes Mateu, Adrián Antuori, Tania Baena, Germán Portela, Judith Llussà, Clara Flamarich, Laura Soldevila, Montserrat Tenesa, Ricard Pérez, Elsa Plasencia, Jordi Bechini, Maria Lluïsa Pedro-Botet, Bonaventura Clotet, Cristina Vilaplana
Published in: Frontiers in Public Health, Issue 11, 2023, ISSN 2296-2565
Publisher: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1175482

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group (opens in new window)

Author(s): Solomon Tibebu Melkie, Lilibeth Arias, Chiara Farroni, Mateja Jankovic Makek, Delia Goletti, Cristina Vilaplana
Published in: European Respiratory Review, Issue 31, 2022, Page(s) 210218, ISSN 0905-9180
Publisher: European Respiratory Society
DOI: 10.1183/16000617.0218-2021

Cost-effectiveness of active tuberculosis screening among high-risk populations in low tuberculosis incidence countries: a systematic review, 2008 to 2023 (opens in new window)

Author(s): Nino Gogichadze, Arnau Sagrera, José Ángel Vicente, Joan-Pau Millet, Francesc López-Seguí, Cristina Vilaplana
Published in: Eurosurveillance, Issue 29, 2024, ISSN 1560-7917
Publisher: European Centre for Disease Prevention and Control
DOI: 10.2807/1560-7917.es.2024.29.12.2300614

IN_CERT - The work process video (opens in new window)

Author(s): Alcañiz, Adolf
Published in: 2022
Publisher: Adolf Alcañiz
DOI: 10.5281/zenodo.5884766

SMA-TB 1st Newsletter (opens in new window)

Author(s): Maciejewska, Iwona; Arias de la Cruz, Lilibeth; Jérôme Nigou; Émilie Layre; Neil Martinson; Ziyaad Waja; Anne Margarita Dyrhol-Riise; Nestani Tukvadze; Sergo Vashakidze; Judith Farrés; Tom H.M. Ottenhoff; Mahavir Singh; Maria Rosa SarriasVilaplana, Cristina
Published in: Issue 1, 2020
Publisher: SMA-TB Consortium
DOI: 10.5281/zenodo.5503535

IN_CERT Programme (opens in new window)

Author(s): Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Published in: 2021
Publisher: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Basic information on Tuberculosis to be shared during communication activities (opens in new window)

Author(s): Nino Gogichadze; Cristina Vilaplana; Arnau Sagrera; Vira Buhiichyk; Joan Pau Millet; Raquel Prieto García; Jesús Edison Ospina; Laura Ginès; Pepón Meneses
Published in: Issue 1, 2022
Publisher: SMA-TB Consortium
DOI: 10.5281/zenodo.7476230

SMA-TB 3rd Newsletter (opens in new window)

Author(s): Maciejewska, Iwona; Arias, Lilibeth; Vilaplana, Cristina; Villar-Hernández, Raquel
Published in: Issue 3, 2024
Publisher: SMA-TB Consortium
DOI: 10.5281/zenodo.10727312

SMA-TB 2nd Newsletter (opens in new window)

Author(s): Maciejewska, Iwona; Arias Lilibeth; Gogichadze, Nino; Nigou, Jérôme; Layre, Émilie; Martinson, Neil; Waja, Ziyaad; Dyrhol-Riise, Anne Margarita; Tukvadze, Nestani; Farrés, Judith; Ottenhoff, Tom H.M.; Singh, Mahavir; Sarrias, Maria-Rosa; Vashakidze, SergoVilaplana, Cristina
Published in: Issue 2, 2021
Publisher: SMA-TB Consortium
DOI: 10.5281/zenodo.5971772

Templates to be used in Project management and in Clinical Trial Monitoring (opens in new window)

Author(s): Arias, Lilibeth, Vilaplana, Cristina, Fonseca, Kaori L., Martinson, Neil, Waja, Ziyaad, Vashakidze, Sergo, Tukvadze, Nestani, Korinteli, Tamta, Chirgadze, Tamar, & Witbooi, Denise
Published in: 2021
Publisher: SMA-TB Consortia
DOI: 10.5281/zenodo.7457938

Tot just veiem la llum al final del túnel - We are only just seeing the light at the end of the tunnel (opens in new window)

Author(s): Cristina Vilaplana
Published in: IN_CERT (UN-CERTAIN): ART, SCIENCE AND THOUGHT SINCE THE PANDEMIC, Issue Oct 29, 2021, 2021, Page(s) 29-31, 127-128, 162-163
Publisher: Ajuntament d'Alella
DOI: 10.5281/zenodo.5897277

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