A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy in TB patients.

Informations projet

SMA-TB

N° de convention de subvention: 847762

DOI

10.3030/847762

Projet clôturé

Date de signature de la CE 6 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 31 Decembre 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 388 104,00

Contribution de l’UE

€ 6 388 104,00

Coordonné par

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (18)

Update of the Communication and Dissemination Plan No. 3

Communication and Dissemination Plan with updates included if needed.

Report on the clinical validation of relevant biomarkers and tests Final

Report on the results of the study of host factors. Can be the related papers published.

List of relevant biomarkers

List of the biomarkers identified within SMA-TB as relevant for the clinical outcome, the response to treatment or for other reasons.

Ethical Report No.3

Report on the Ethical issues

Report on the communication and dissemination activities No. 2

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period

Communication and Dissemination Plan

Communication and Dissemination Plan drafted, approved and published.

Report on the communication and dissemination activities No. 3

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Update of the Communication and Dissemination Plan No. 1

Communication and Dissemination Plan with updates included if needed.

Uploading results in the study registry.

Reporting the results in the study registry -public database. Can be the related papers issued.

Report on main findings of the project final workshop

Report on main findings of the project final workshop, including the program and feedback.

Report on the study of host factors Final

Report on the results of the study of host factors. Can be the related papers published.

Update of the Communication and Dissemination Plan No. 2

Communication and Dissemination Plan with updates included if needed

Ethical Report No.1

Report on the Ethical issues.

Report on the communication and dissemination activities No. 1

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Ethical Report No.4

Report on the Ethical issues.

Ethical Report Final

Report on the Ethical issues.

Report on the study of pathogen factors Final

Report on the performance and status of the host factors studied, including results if available.

Ethical Report No.2

Report on the Ethical issues

Other (3)

Stratification Algorithm

Description of the algorithm able to predict patients’ clinical outcome and/or response to intervention to be used at clinical level to better manage patients and tailor treatment. Can be associated to a related paper published.

Project website

Website online.

Sites capacity package (includes training documents and videos, working procedures and work flow infographics) Final

Material needed for the good performance of the CT to be delivered to the sites (including protocols and training material).

Publications

Peer reviewed articles (15)

Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic

Auteurs: Judith Farrés, José Luis Ruiz, José Manuel Mas, Lilibeth Arias, Maria-Rosa Sarrias, Carolina Armengol, Pere-Joan Cardona, José A. Muñoz-Moreno, Miriam Vilaplana, Belén Arranz, Judith Usall, Antoni Serrano-Blanco, Cristina Vilaplana
Publié dans: BMJ Open, Numéro 11:e052140, 2021, ISSN 2044-6055
Éditeur: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-052140

Multifaceted Roles of CD5L in Infectious and Sterile Inflammation

Auteurs: Lidia Sanchez-Moral, Neus Ràfols, Clara Martori, Tony Paul, Érica Téllez, Maria-Rosa Sarrias
Publié dans: International Journal of Molecular Sciences, Numéro 22/8, 2021, Page(s) 4076, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084076

SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen

Auteurs: Lilibeth Arias, Kennedy Otwombe, Ziyaad Waja, Nestani Tukvadze, Tamta Korinteli, Tumelo Moloantoa, Kaori L Fonseca, Natasha Pillay, Thabiso Seiphetlo, Dan Ouchi-Vernet, Adrian Siles, Lidia Carabias, Carles Quiñones, Sergo Vashakidze, Neil Martinson & Cristina Vilaplana
Publié dans: Trials, 2023, ISSN 1745-6215
Éditeur: BioMed Central
DOI: 10.1186/s13063-023-07448-0

A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

Auteurs: Sergio Fabián Mosquera-Restrepo, Sophie Zuberogoïtia, Lucie Gouxette, Emilie Layre, Martine Gilleron, Alexandre Stella, David Rengel, Odile Burlet-Schiltz, Ana Cecilia Caro, Luis F. Garcia, César Segura, Carlos Alberto Peláez Jaramillo, Mauricio Rojas & Jérôme Nigou
Publié dans: Nature Communications, Numéro 14 December 2022, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-35453-5

Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients

Auteurs: Marthe Jøntvedt Jørgensen, Kristin G. Nore, Hans Christian D. Aass, Emilie Layre, Jérôme Nigou, Rasmus Mortensen, Kjetil Tasken, Dag Kvale, Synne Jenum, Kristian Tonby, Anne Ma Dyrhol-Riise
Publié dans: Frontiers in Cellular and Infection Microbiology, Numéro 11, 2021, ISSN 2235-2988
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.669623

Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids

Auteurs: Margarida Correia-Neves, Jérôme Nigou, Zaynab Mousavian, Christopher Sundling and Gunilla Källenius
Publié dans: Frontiers in Immunology, Numéro Front. Immunol., 02 December 2022, 2022, ISSN 1664-3224
Éditeur: Frontiers in immunology
DOI: 10.3389/fimmu.2022.1035122

Macrophage CD5L is a target for cancer immunotherapy

Auteurs: Lidia Sanchez-Moral, Tony Paul, Clara Martori, Joan Font-Díaz, Lucía Sanjurjo, Gemma Aran, Érica Téllez, Julià Blanco, Jorge Carrillo, Masaoki Ito, Martina Tuttolomondo, Henrik J. Ditzel, Caterina Fumagalli, Gustavo Tapia, Julia Sidorova, Helena Masnou, Marco-Antonio Fernández-Sanmartín, Juan-José Lozano, Cristina Vilaplana, Alhelí Rodriguez-Cortés, Carolina Armengol, Annabel F. Valledor
Publié dans: eBioMedicine, Numéro 91, 2024, Page(s) 104555, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104555

Exhaled breath specimens subjected to point-of-care lipoarabinomannan testing

Auteurs: F. Nabeemeeah, R. Sabet, T. Moloantoa, Z. Waja, Z. Pretorius, K. Majoro, M. Letutu-Xaba, C. Vilaplana, J. Nigou, N. Martinson
Publié dans: The International Journal of Tuberculosis and Lung Disease, Numéro 27, 2023, Page(s) 703-705, ISSN 1027-3719
Éditeur: International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories
DOI: 10.5588/ijtld.23.0128

Host‐directed therapy to combat mycobacterial infections*

Auteurs: Gül Kilinç, Anno Saris, Tom H. M. Ottenhoff, Mariëlle C. Haks
Publié dans: Immunological Reviews, Numéro 301/1, 2021, Page(s) 62-83, ISSN 0105-2896
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/imr.12951

Mycobacterium manresensis induces trained immunity in vitro

Auteurs: Miquel de Homdedeu, Lidia Sanchez-Moral, Concepció Violán, Neus Ràfols, Dan Ouchi, Berta Martín, Miguel A. Peinado, Alhelí Rodríguez-Cortés, Marta Arch-Sisquella, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Nuria Izquierdo-Useros, Betlem Salvador, Joan Matllo, Sergi López-Serrano, Joaquim Segalés, Cristina Vilaplana, Pere Torán-Monserrat, Rosa Morros, Ramon Monfà, Maria-Rosa Sarrias,
Publié dans: iScience, Numéro 26, 2024, Page(s) 106873, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2023.106873

A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings

Auteurs: Arantxa Romero-Tamarit, Xavier Vallès, María Munar-García, Juan Espinosa-Pereiro, Núria Saborit, Ma. Teresa Tortola, Zoran Stojanovic, Sílvia Roure, Adrián Antuori, Pere-Joan Cardona, Antoni Soriano-Arandes, Andrea Martin-Nalda, María Espiau, Maria Luiza de Souza-Galvão, Ma. Ángeles Jiménez, Antoni Noguera-Julian, Israel Molina, Xavier Casas, Marisol Domínguez-Álvarez, Neus Jové, Nino
Publié dans: Infection, Numéro 52, 2024, Page(s) 611-623, ISSN 0300-8126
Éditeur: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02184-2

<scp>CD5L</scp> is upregulated upon infection with <i>Mycobacterium tuberculosis</i> with no effect on disease progression

Auteurs: Marcos S. Cardoso, Rute Gonçalves, Liliana Oliveira, Diogo Silvério, Érica Téllez, Tony Paul, Maria Rosa Sarrias, Alexandre M. Carmo, Margarida Saraiva
Publié dans: Immunology, 2024, ISSN 0019-2805
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/imm.13825

Disseminated tuberculosis and diagnosis delay during the COVID-19 era in a Western European country: a case series analysis

Auteurs: Sílvia Roure, Xavier Vallès, Nieves Sopena, Rosa Maria Benítez, Esteban A. Reynaga, Carmen Bracke, Cora Loste, Lourdes Mateu, Adrián Antuori, Tania Baena, Germán Portela, Judith Llussà, Clara Flamarich, Laura Soldevila, Montserrat Tenesa, Ricard Pérez, Elsa Plasencia, Jordi Bechini, Maria Lluïsa Pedro-Botet, Bonaventura Clotet, Cristina Vilaplana
Publié dans: Frontiers in Public Health, Numéro 11, 2023, ISSN 2296-2565
Éditeur: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1175482

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

Auteurs: Solomon Tibebu Melkie, Lilibeth Arias, Chiara Farroni, Mateja Jankovic Makek, Delia Goletti, Cristina Vilaplana
Publié dans: European Respiratory Review, Numéro 31, 2022, Page(s) 210218, ISSN 0905-9180
Éditeur: European Respiratory Society
DOI: 10.1183/16000617.0218-2021

Cost-effectiveness of active tuberculosis screening among high-risk populations in low tuberculosis incidence countries: a systematic review, 2008 to 2023

Auteurs: Nino Gogichadze, Arnau Sagrera, José Ángel Vicente, Joan-Pau Millet, Francesc López-Seguí, Cristina Vilaplana
Publié dans: Eurosurveillance, Numéro 29, 2024, ISSN 1560-7917
Éditeur: European Centre for Disease Prevention and Control
DOI: 10.2807/1560-7917.es.2024.29.12.2300614

Other (7)

IN_CERT - The work process video

Auteurs: Alcañiz, Adolf
Publié dans: 2022
Éditeur: Adolf Alcañiz
DOI: 10.5281/zenodo.5884766

SMA-TB 1st Newsletter

Auteurs: Maciejewska, Iwona; Arias de la Cruz, Lilibeth; Jérôme Nigou; Émilie Layre; Neil Martinson; Ziyaad Waja; Anne Margarita Dyrhol-Riise; Nestani Tukvadze; Sergo Vashakidze; Judith Farrés; Tom H.M. Ottenhoff; Mahavir Singh; Maria Rosa SarriasVilaplana, Cristina
Publié dans: Numéro 1, 2020
Éditeur: SMA-TB Consortium
DOI: 10.5281/zenodo.5503535

IN_CERT Programme

Auteurs: Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Publié dans: 2021
Éditeur: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Basic information on Tuberculosis to be shared during communication activities

Auteurs: Nino Gogichadze; Cristina Vilaplana; Arnau Sagrera; Vira Buhiichyk; Joan Pau Millet; Raquel Prieto García; Jesús Edison Ospina; Laura Ginès; Pepón Meneses
Publié dans: Numéro 1, 2022
Éditeur: SMA-TB Consortium
DOI: 10.5281/zenodo.7476230

SMA-TB 3rd Newsletter

Auteurs: Maciejewska, Iwona; Arias, Lilibeth; Vilaplana, Cristina; Villar-Hernández, Raquel
Publié dans: Numéro 3, 2024
Éditeur: SMA-TB Consortium
DOI: 10.5281/zenodo.10727312

SMA-TB 2nd Newsletter

Auteurs: Maciejewska, Iwona; Arias Lilibeth; Gogichadze, Nino; Nigou, Jérôme; Layre, Émilie; Martinson, Neil; Waja, Ziyaad; Dyrhol-Riise, Anne Margarita; Tukvadze, Nestani; Farrés, Judith; Ottenhoff, Tom H.M.; Singh, Mahavir; Sarrias, Maria-Rosa; Vashakidze, SergoVilaplana, Cristina
Publié dans: Numéro 2, 2021
Éditeur: SMA-TB Consortium
DOI: 10.5281/zenodo.5971772

Templates to be used in Project management and in Clinical Trial Monitoring

Auteurs: Arias, Lilibeth, Vilaplana, Cristina, Fonseca, Kaori L., Martinson, Neil, Waja, Ziyaad, Vashakidze, Sergo, Tukvadze, Nestani, Korinteli, Tamta, Chirgadze, Tamar, & Witbooi, Denise
Publié dans: 2021
Éditeur: SMA-TB Consortia
DOI: 10.5281/zenodo.7457938

Book chapters (1)

Tot just veiem la llum al final del túnel - We are only just seeing the light at the end of the tunnel

Auteurs: Cristina Vilaplana
Publié dans: IN_CERT (UN-CERTAIN): ART, SCIENCE AND THOUGHT SINCE THE PANDEMIC, Numéro Oct 29, 2021, 2021, Page(s) 29-31, 127-128, 162-163
Éditeur: Ajuntament d'Alella
DOI: 10.5281/zenodo.5897277