A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy in TB patients.

Informacje na temat projektu

SMA-TB

Identyfikator umowy o grant: 847762

DOI

10.3030/847762

Projekt został zamknięty

Data podpisania przez KE 6 Grudnia 2019

Data rozpoczęcia 1 Stycznia 2020

Data zakończenia 31 Grudnia 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 388 104,00

Wkład UE

€ 6 388 104,00

Koordynowany przez

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (18)

Update of the Communication and Dissemination Plan No. 3

Communication and Dissemination Plan with updates included if needed.

Report on the clinical validation of relevant biomarkers and tests Final

Report on the results of the study of host factors. Can be the related papers published.

List of relevant biomarkers

List of the biomarkers identified within SMA-TB as relevant for the clinical outcome, the response to treatment or for other reasons.

Ethical Report No.3

Report on the Ethical issues

Report on the communication and dissemination activities No. 2

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period

Communication and Dissemination Plan

Communication and Dissemination Plan drafted, approved and published.

Report on the communication and dissemination activities No. 3

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Update of the Communication and Dissemination Plan No. 1

Communication and Dissemination Plan with updates included if needed.

Uploading results in the study registry.

Reporting the results in the study registry -public database. Can be the related papers issued.

Report on main findings of the project final workshop

Report on main findings of the project final workshop, including the program and feedback.

Report on the study of host factors Final

Report on the results of the study of host factors. Can be the related papers published.

Update of the Communication and Dissemination Plan No. 2

Communication and Dissemination Plan with updates included if needed

Ethical Report No.1

Report on the Ethical issues.

Report on the communication and dissemination activities No. 1

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Ethical Report No.4

Report on the Ethical issues.

Ethical Report Final

Report on the Ethical issues.

Report on the study of pathogen factors Final

Report on the performance and status of the host factors studied, including results if available.

Ethical Report No.2

Report on the Ethical issues

Other (3)

Stratification Algorithm

Description of the algorithm able to predict patients’ clinical outcome and/or response to intervention to be used at clinical level to better manage patients and tailor treatment. Can be associated to a related paper published.

Project website

Website online.

Sites capacity package (includes training documents and videos, working procedures and work flow infographics) Final

Material needed for the good performance of the CT to be delivered to the sites (including protocols and training material).

Publikacje

Peer reviewed articles (15)

Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic

Autorzy: Judith Farrés, José Luis Ruiz, José Manuel Mas, Lilibeth Arias, Maria-Rosa Sarrias, Carolina Armengol, Pere-Joan Cardona, José A. Muñoz-Moreno, Miriam Vilaplana, Belén Arranz, Judith Usall, Antoni Serrano-Blanco, Cristina Vilaplana
Opublikowane w: BMJ Open, Numer 11:e052140, 2021, ISSN 2044-6055
Wydawca: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-052140

Multifaceted Roles of CD5L in Infectious and Sterile Inflammation

Autorzy: Lidia Sanchez-Moral, Neus Ràfols, Clara Martori, Tony Paul, Érica Téllez, Maria-Rosa Sarrias
Opublikowane w: International Journal of Molecular Sciences, Numer 22/8, 2021, Strona(/y) 4076, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084076

SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen

Autorzy: Lilibeth Arias, Kennedy Otwombe, Ziyaad Waja, Nestani Tukvadze, Tamta Korinteli, Tumelo Moloantoa, Kaori L Fonseca, Natasha Pillay, Thabiso Seiphetlo, Dan Ouchi-Vernet, Adrian Siles, Lidia Carabias, Carles Quiñones, Sergo Vashakidze, Neil Martinson & Cristina Vilaplana
Opublikowane w: Trials, 2023, ISSN 1745-6215
Wydawca: BioMed Central
DOI: 10.1186/s13063-023-07448-0

A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

Autorzy: Sergio Fabián Mosquera-Restrepo, Sophie Zuberogoïtia, Lucie Gouxette, Emilie Layre, Martine Gilleron, Alexandre Stella, David Rengel, Odile Burlet-Schiltz, Ana Cecilia Caro, Luis F. Garcia, César Segura, Carlos Alberto Peláez Jaramillo, Mauricio Rojas & Jérôme Nigou
Opublikowane w: Nature Communications, Numer 14 December 2022, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-35453-5

Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients

Autorzy: Marthe Jøntvedt Jørgensen, Kristin G. Nore, Hans Christian D. Aass, Emilie Layre, Jérôme Nigou, Rasmus Mortensen, Kjetil Tasken, Dag Kvale, Synne Jenum, Kristian Tonby, Anne Ma Dyrhol-Riise
Opublikowane w: Frontiers in Cellular and Infection Microbiology, Numer 11, 2021, ISSN 2235-2988
Wydawca: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.669623

Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids

Autorzy: Margarida Correia-Neves, Jérôme Nigou, Zaynab Mousavian, Christopher Sundling and Gunilla Källenius
Opublikowane w: Frontiers in Immunology, Numer Front. Immunol., 02 December 2022, 2022, ISSN 1664-3224
Wydawca: Frontiers in immunology
DOI: 10.3389/fimmu.2022.1035122

Macrophage CD5L is a target for cancer immunotherapy

Autorzy: Lidia Sanchez-Moral, Tony Paul, Clara Martori, Joan Font-Díaz, Lucía Sanjurjo, Gemma Aran, Érica Téllez, Julià Blanco, Jorge Carrillo, Masaoki Ito, Martina Tuttolomondo, Henrik J. Ditzel, Caterina Fumagalli, Gustavo Tapia, Julia Sidorova, Helena Masnou, Marco-Antonio Fernández-Sanmartín, Juan-José Lozano, Cristina Vilaplana, Alhelí Rodriguez-Cortés, Carolina Armengol, Annabel F. Valledor
Opublikowane w: eBioMedicine, Numer 91, 2024, Strona(/y) 104555, ISSN 2352-3964
Wydawca: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104555

Exhaled breath specimens subjected to point-of-care lipoarabinomannan testing

Autorzy: F. Nabeemeeah, R. Sabet, T. Moloantoa, Z. Waja, Z. Pretorius, K. Majoro, M. Letutu-Xaba, C. Vilaplana, J. Nigou, N. Martinson
Opublikowane w: The International Journal of Tuberculosis and Lung Disease, Numer 27, 2023, Strona(/y) 703-705, ISSN 1027-3719
Wydawca: International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories
DOI: 10.5588/ijtld.23.0128

Host‐directed therapy to combat mycobacterial infections*

Autorzy: Gül Kilinç, Anno Saris, Tom H. M. Ottenhoff, Mariëlle C. Haks
Opublikowane w: Immunological Reviews, Numer 301/1, 2021, Strona(/y) 62-83, ISSN 0105-2896
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imr.12951

Mycobacterium manresensis induces trained immunity in vitro

Autorzy: Miquel de Homdedeu, Lidia Sanchez-Moral, Concepció Violán, Neus Ràfols, Dan Ouchi, Berta Martín, Miguel A. Peinado, Alhelí Rodríguez-Cortés, Marta Arch-Sisquella, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Nuria Izquierdo-Useros, Betlem Salvador, Joan Matllo, Sergi López-Serrano, Joaquim Segalés, Cristina Vilaplana, Pere Torán-Monserrat, Rosa Morros, Ramon Monfà, Maria-Rosa Sarrias,
Opublikowane w: iScience, Numer 26, 2024, Strona(/y) 106873, ISSN 2589-0042
Wydawca: Elsevier
DOI: 10.1016/j.isci.2023.106873

A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings

Autorzy: Arantxa Romero-Tamarit, Xavier Vallès, María Munar-García, Juan Espinosa-Pereiro, Núria Saborit, Ma. Teresa Tortola, Zoran Stojanovic, Sílvia Roure, Adrián Antuori, Pere-Joan Cardona, Antoni Soriano-Arandes, Andrea Martin-Nalda, María Espiau, Maria Luiza de Souza-Galvão, Ma. Ángeles Jiménez, Antoni Noguera-Julian, Israel Molina, Xavier Casas, Marisol Domínguez-Álvarez, Neus Jové, Nino
Opublikowane w: Infection, Numer 52, 2024, Strona(/y) 611-623, ISSN 0300-8126
Wydawca: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02184-2

<scp>CD5L</scp> is upregulated upon infection with <i>Mycobacterium tuberculosis</i> with no effect on disease progression

Autorzy: Marcos S. Cardoso, Rute Gonçalves, Liliana Oliveira, Diogo Silvério, Érica Téllez, Tony Paul, Maria Rosa Sarrias, Alexandre M. Carmo, Margarida Saraiva
Opublikowane w: Immunology, 2024, ISSN 0019-2805
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/imm.13825

Disseminated tuberculosis and diagnosis delay during the COVID-19 era in a Western European country: a case series analysis

Autorzy: Sílvia Roure, Xavier Vallès, Nieves Sopena, Rosa Maria Benítez, Esteban A. Reynaga, Carmen Bracke, Cora Loste, Lourdes Mateu, Adrián Antuori, Tania Baena, Germán Portela, Judith Llussà, Clara Flamarich, Laura Soldevila, Montserrat Tenesa, Ricard Pérez, Elsa Plasencia, Jordi Bechini, Maria Lluïsa Pedro-Botet, Bonaventura Clotet, Cristina Vilaplana
Opublikowane w: Frontiers in Public Health, Numer 11, 2023, ISSN 2296-2565
Wydawca: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1175482

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

Autorzy: Solomon Tibebu Melkie, Lilibeth Arias, Chiara Farroni, Mateja Jankovic Makek, Delia Goletti, Cristina Vilaplana
Opublikowane w: European Respiratory Review, Numer 31, 2022, Strona(/y) 210218, ISSN 0905-9180
Wydawca: European Respiratory Society
DOI: 10.1183/16000617.0218-2021

Cost-effectiveness of active tuberculosis screening among high-risk populations in low tuberculosis incidence countries: a systematic review, 2008 to 2023

Autorzy: Nino Gogichadze, Arnau Sagrera, José Ángel Vicente, Joan-Pau Millet, Francesc López-Seguí, Cristina Vilaplana
Opublikowane w: Eurosurveillance, Numer 29, 2024, ISSN 1560-7917
Wydawca: European Centre for Disease Prevention and Control
DOI: 10.2807/1560-7917.es.2024.29.12.2300614

Other (7)

IN_CERT - The work process video

Autorzy: Alcañiz, Adolf
Opublikowane w: 2022
Wydawca: Adolf Alcañiz
DOI: 10.5281/zenodo.5884766

SMA-TB 1st Newsletter

Autorzy: Maciejewska, Iwona; Arias de la Cruz, Lilibeth; Jérôme Nigou; Émilie Layre; Neil Martinson; Ziyaad Waja; Anne Margarita Dyrhol-Riise; Nestani Tukvadze; Sergo Vashakidze; Judith Farrés; Tom H.M. Ottenhoff; Mahavir Singh; Maria Rosa SarriasVilaplana, Cristina
Opublikowane w: Numer 1, 2020
Wydawca: SMA-TB Consortium
DOI: 10.5281/zenodo.5503535

IN_CERT Programme

Autorzy: Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Opublikowane w: 2021
Wydawca: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Basic information on Tuberculosis to be shared during communication activities

Autorzy: Nino Gogichadze; Cristina Vilaplana; Arnau Sagrera; Vira Buhiichyk; Joan Pau Millet; Raquel Prieto García; Jesús Edison Ospina; Laura Ginès; Pepón Meneses
Opublikowane w: Numer 1, 2022
Wydawca: SMA-TB Consortium
DOI: 10.5281/zenodo.7476230

SMA-TB 3rd Newsletter

Autorzy: Maciejewska, Iwona; Arias, Lilibeth; Vilaplana, Cristina; Villar-Hernández, Raquel
Opublikowane w: Numer 3, 2024
Wydawca: SMA-TB Consortium
DOI: 10.5281/zenodo.10727312

SMA-TB 2nd Newsletter

Autorzy: Maciejewska, Iwona; Arias Lilibeth; Gogichadze, Nino; Nigou, Jérôme; Layre, Émilie; Martinson, Neil; Waja, Ziyaad; Dyrhol-Riise, Anne Margarita; Tukvadze, Nestani; Farrés, Judith; Ottenhoff, Tom H.M.; Singh, Mahavir; Sarrias, Maria-Rosa; Vashakidze, SergoVilaplana, Cristina
Opublikowane w: Numer 2, 2021
Wydawca: SMA-TB Consortium
DOI: 10.5281/zenodo.5971772

Templates to be used in Project management and in Clinical Trial Monitoring

Autorzy: Arias, Lilibeth, Vilaplana, Cristina, Fonseca, Kaori L., Martinson, Neil, Waja, Ziyaad, Vashakidze, Sergo, Tukvadze, Nestani, Korinteli, Tamta, Chirgadze, Tamar, & Witbooi, Denise
Opublikowane w: 2021
Wydawca: SMA-TB Consortia
DOI: 10.5281/zenodo.7457938

Book chapters (1)

Tot just veiem la llum al final del túnel - We are only just seeing the light at the end of the tunnel

Autorzy: Cristina Vilaplana
Opublikowane w: IN_CERT (UN-CERTAIN): ART, SCIENCE AND THOUGHT SINCE THE PANDEMIC, Numer Oct 29, 2021, 2021, Strona(/y) 29-31, 127-128, 162-163
Wydawca: Ajuntament d'Alella
DOI: 10.5281/zenodo.5897277