A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy in TB patients.

Informazioni relative al progetto

SMA-TB

ID dell’accordo di sovvenzione: 847762

DOI

10.3030/847762

Progetto chiuso

Data della firma CE 6 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 388 104,00

Contributo UE

€ 6 388 104,00

Coordinato da

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (18)

Update of the Communication and Dissemination Plan No. 3

Communication and Dissemination Plan with updates included if needed.

Report on the clinical validation of relevant biomarkers and tests Final

Report on the results of the study of host factors. Can be the related papers published.

List of relevant biomarkers

List of the biomarkers identified within SMA-TB as relevant for the clinical outcome, the response to treatment or for other reasons.

Ethical Report No.3

Report on the Ethical issues

Report on the communication and dissemination activities No. 2

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period

Communication and Dissemination Plan

Communication and Dissemination Plan drafted, approved and published.

Report on the communication and dissemination activities No. 3

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Update of the Communication and Dissemination Plan No. 1

Communication and Dissemination Plan with updates included if needed.

Uploading results in the study registry.

Reporting the results in the study registry -public database. Can be the related papers issued.

Report on main findings of the project final workshop

Report on main findings of the project final workshop, including the program and feedback.

Report on the study of host factors Final

Report on the results of the study of host factors. Can be the related papers published.

Update of the Communication and Dissemination Plan No. 2

Communication and Dissemination Plan with updates included if needed

Ethical Report No.1

Report on the Ethical issues.

Report on the communication and dissemination activities No. 1

Report on all the communication and dissemination activities conducted until the month or delivery and list of those already planned for the next reporting period.

Ethical Report No.4

Report on the Ethical issues.

Ethical Report Final

Report on the Ethical issues.

Report on the study of pathogen factors Final

Report on the performance and status of the host factors studied, including results if available.

Ethical Report No.2

Report on the Ethical issues

Other (3)

Stratification Algorithm

Description of the algorithm able to predict patients’ clinical outcome and/or response to intervention to be used at clinical level to better manage patients and tailor treatment. Can be associated to a related paper published.

Project website

Website online.

Sites capacity package (includes training documents and videos, working procedures and work flow infographics) Final

Material needed for the good performance of the CT to be delivered to the sites (including protocols and training material).

Pubblicazioni

Peer reviewed articles (15)

Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic

Autori: Judith Farrés, José Luis Ruiz, José Manuel Mas, Lilibeth Arias, Maria-Rosa Sarrias, Carolina Armengol, Pere-Joan Cardona, José A. Muñoz-Moreno, Miriam Vilaplana, Belén Arranz, Judith Usall, Antoni Serrano-Blanco, Cristina Vilaplana
Pubblicato in: BMJ Open, Numero 11:e052140, 2021, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-052140

Multifaceted Roles of CD5L in Infectious and Sterile Inflammation

Autori: Lidia Sanchez-Moral, Neus Ràfols, Clara Martori, Tony Paul, Érica Téllez, Maria-Rosa Sarrias
Pubblicato in: International Journal of Molecular Sciences, Numero 22/8, 2021, Pagina/e 4076, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084076

SMA-TB: study protocol for the phase 2b randomized double-blind, placebo-controlled trial to estimate the potential efficacy and safety of two repurposed drugs, acetylsalicylic acid and ibuprofen, for use as adjunct therapy added to, and compared with, the standard WHO recommended TB regimen

Autori: Lilibeth Arias, Kennedy Otwombe, Ziyaad Waja, Nestani Tukvadze, Tamta Korinteli, Tumelo Moloantoa, Kaori L Fonseca, Natasha Pillay, Thabiso Seiphetlo, Dan Ouchi-Vernet, Adrian Siles, Lidia Carabias, Carles Quiñones, Sergo Vashakidze, Neil Martinson & Cristina Vilaplana
Pubblicato in: Trials, 2023, ISSN 1745-6215
Editore: BioMed Central
DOI: 10.1186/s13063-023-07448-0

A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

Autori: Sergio Fabián Mosquera-Restrepo, Sophie Zuberogoïtia, Lucie Gouxette, Emilie Layre, Martine Gilleron, Alexandre Stella, David Rengel, Odile Burlet-Schiltz, Ana Cecilia Caro, Luis F. Garcia, César Segura, Carlos Alberto Peláez Jaramillo, Mauricio Rojas & Jérôme Nigou
Pubblicato in: Nature Communications, Numero 14 December 2022, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-35453-5

Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients

Autori: Marthe Jøntvedt Jørgensen, Kristin G. Nore, Hans Christian D. Aass, Emilie Layre, Jérôme Nigou, Rasmus Mortensen, Kjetil Tasken, Dag Kvale, Synne Jenum, Kristian Tonby, Anne Ma Dyrhol-Riise
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 11, 2021, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.669623

Immunological hyporesponsiveness in tuberculosis: The role of mycobacterial glycolipids

Autori: Margarida Correia-Neves, Jérôme Nigou, Zaynab Mousavian, Christopher Sundling and Gunilla Källenius
Pubblicato in: Frontiers in Immunology, Numero Front. Immunol., 02 December 2022, 2022, ISSN 1664-3224
Editore: Frontiers in immunology
DOI: 10.3389/fimmu.2022.1035122

Macrophage CD5L is a target for cancer immunotherapy

Autori: Lidia Sanchez-Moral, Tony Paul, Clara Martori, Joan Font-Díaz, Lucía Sanjurjo, Gemma Aran, Érica Téllez, Julià Blanco, Jorge Carrillo, Masaoki Ito, Martina Tuttolomondo, Henrik J. Ditzel, Caterina Fumagalli, Gustavo Tapia, Julia Sidorova, Helena Masnou, Marco-Antonio Fernández-Sanmartín, Juan-José Lozano, Cristina Vilaplana, Alhelí Rodriguez-Cortés, Carolina Armengol, Annabel F. Valledor
Pubblicato in: eBioMedicine, Numero 91, 2024, Pagina/e 104555, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104555

Exhaled breath specimens subjected to point-of-care lipoarabinomannan testing

Autori: F. Nabeemeeah, R. Sabet, T. Moloantoa, Z. Waja, Z. Pretorius, K. Majoro, M. Letutu-Xaba, C. Vilaplana, J. Nigou, N. Martinson
Pubblicato in: The International Journal of Tuberculosis and Lung Disease, Numero 27, 2023, Pagina/e 703-705, ISSN 1027-3719
Editore: International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories
DOI: 10.5588/ijtld.23.0128

Host‐directed therapy to combat mycobacterial infections*

Autori: Gül Kilinç, Anno Saris, Tom H. M. Ottenhoff, Mariëlle C. Haks
Pubblicato in: Immunological Reviews, Numero 301/1, 2021, Pagina/e 62-83, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.12951

Mycobacterium manresensis induces trained immunity in vitro

Autori: Miquel de Homdedeu, Lidia Sanchez-Moral, Concepció Violán, Neus Ràfols, Dan Ouchi, Berta Martín, Miguel A. Peinado, Alhelí Rodríguez-Cortés, Marta Arch-Sisquella, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Nuria Izquierdo-Useros, Betlem Salvador, Joan Matllo, Sergi López-Serrano, Joaquim Segalés, Cristina Vilaplana, Pere Torán-Monserrat, Rosa Morros, Ramon Monfà, Maria-Rosa Sarrias,
Pubblicato in: iScience, Numero 26, 2024, Pagina/e 106873, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2023.106873

A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings

Autori: Arantxa Romero-Tamarit, Xavier Vallès, María Munar-García, Juan Espinosa-Pereiro, Núria Saborit, Ma. Teresa Tortola, Zoran Stojanovic, Sílvia Roure, Adrián Antuori, Pere-Joan Cardona, Antoni Soriano-Arandes, Andrea Martin-Nalda, María Espiau, Maria Luiza de Souza-Galvão, Ma. Ángeles Jiménez, Antoni Noguera-Julian, Israel Molina, Xavier Casas, Marisol Domínguez-Álvarez, Neus Jové, Nino
Pubblicato in: Infection, Numero 52, 2024, Pagina/e 611-623, ISSN 0300-8126
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/s15010-024-02184-2

<scp>CD5L</scp> is upregulated upon infection with <i>Mycobacterium tuberculosis</i> with no effect on disease progression

Autori: Marcos S. Cardoso, Rute Gonçalves, Liliana Oliveira, Diogo Silvério, Érica Téllez, Tony Paul, Maria Rosa Sarrias, Alexandre M. Carmo, Margarida Saraiva
Pubblicato in: Immunology, 2024, ISSN 0019-2805
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imm.13825

Disseminated tuberculosis and diagnosis delay during the COVID-19 era in a Western European country: a case series analysis

Autori: Sílvia Roure, Xavier Vallès, Nieves Sopena, Rosa Maria Benítez, Esteban A. Reynaga, Carmen Bracke, Cora Loste, Lourdes Mateu, Adrián Antuori, Tania Baena, Germán Portela, Judith Llussà, Clara Flamarich, Laura Soldevila, Montserrat Tenesa, Ricard Pérez, Elsa Plasencia, Jordi Bechini, Maria Lluïsa Pedro-Botet, Bonaventura Clotet, Cristina Vilaplana
Pubblicato in: Frontiers in Public Health, Numero 11, 2023, ISSN 2296-2565
Editore: Frontiers Media SA
DOI: 10.3389/fpubh.2023.1175482

The role of antibodies in tuberculosis diagnosis, prophylaxis and therapy: a review from the ESGMYC study group

Autori: Solomon Tibebu Melkie, Lilibeth Arias, Chiara Farroni, Mateja Jankovic Makek, Delia Goletti, Cristina Vilaplana
Pubblicato in: European Respiratory Review, Numero 31, 2022, Pagina/e 210218, ISSN 0905-9180
Editore: European Respiratory Society
DOI: 10.1183/16000617.0218-2021

Cost-effectiveness of active tuberculosis screening among high-risk populations in low tuberculosis incidence countries: a systematic review, 2008 to 2023

Autori: Nino Gogichadze, Arnau Sagrera, José Ángel Vicente, Joan-Pau Millet, Francesc López-Seguí, Cristina Vilaplana
Pubblicato in: Eurosurveillance, Numero 29, 2024, ISSN 1560-7917
Editore: European Centre for Disease Prevention and Control
DOI: 10.2807/1560-7917.es.2024.29.12.2300614

Other (7)

IN_CERT - The work process video

Autori: Alcañiz, Adolf
Pubblicato in: 2022
Editore: Adolf Alcañiz
DOI: 10.5281/zenodo.5884766

SMA-TB 1st Newsletter

Autori: Maciejewska, Iwona; Arias de la Cruz, Lilibeth; Jérôme Nigou; Émilie Layre; Neil Martinson; Ziyaad Waja; Anne Margarita Dyrhol-Riise; Nestani Tukvadze; Sergo Vashakidze; Judith Farrés; Tom H.M. Ottenhoff; Mahavir Singh; Maria Rosa SarriasVilaplana, Cristina
Pubblicato in: Numero 1, 2020
Editore: SMA-TB Consortium
DOI: 10.5281/zenodo.5503535

IN_CERT Programme

Autori: Mercè Pomer; Queralt Morros; Roger Paredes; Cristina Vilaplana; Lourdes Mateu; Manel Guerrero; Jo Milne; Nora Ancarola; Adolf Alcañiz
Pubblicato in: 2021
Editore: Ajuntament d'Alella
DOI: 10.5281/zenodo.5608507

Basic information on Tuberculosis to be shared during communication activities

Autori: Nino Gogichadze; Cristina Vilaplana; Arnau Sagrera; Vira Buhiichyk; Joan Pau Millet; Raquel Prieto García; Jesús Edison Ospina; Laura Ginès; Pepón Meneses
Pubblicato in: Numero 1, 2022
Editore: SMA-TB Consortium
DOI: 10.5281/zenodo.7476230

SMA-TB 3rd Newsletter

Autori: Maciejewska, Iwona; Arias, Lilibeth; Vilaplana, Cristina; Villar-Hernández, Raquel
Pubblicato in: Numero 3, 2024
Editore: SMA-TB Consortium
DOI: 10.5281/zenodo.10727312

SMA-TB 2nd Newsletter

Autori: Maciejewska, Iwona; Arias Lilibeth; Gogichadze, Nino; Nigou, Jérôme; Layre, Émilie; Martinson, Neil; Waja, Ziyaad; Dyrhol-Riise, Anne Margarita; Tukvadze, Nestani; Farrés, Judith; Ottenhoff, Tom H.M.; Singh, Mahavir; Sarrias, Maria-Rosa; Vashakidze, SergoVilaplana, Cristina
Pubblicato in: Numero 2, 2021
Editore: SMA-TB Consortium
DOI: 10.5281/zenodo.5971772

Templates to be used in Project management and in Clinical Trial Monitoring

Autori: Arias, Lilibeth, Vilaplana, Cristina, Fonseca, Kaori L., Martinson, Neil, Waja, Ziyaad, Vashakidze, Sergo, Tukvadze, Nestani, Korinteli, Tamta, Chirgadze, Tamar, & Witbooi, Denise
Pubblicato in: 2021
Editore: SMA-TB Consortia
DOI: 10.5281/zenodo.7457938

Book chapters (1)

Tot just veiem la llum al final del túnel - We are only just seeing the light at the end of the tunnel

Autori: Cristina Vilaplana
Pubblicato in: IN_CERT (UN-CERTAIN): ART, SCIENCE AND THOUGHT SINCE THE PANDEMIC, Numero Oct 29, 2021, 2021, Pagina/e 29-31, 127-128, 162-163
Editore: Ajuntament d'Alella
DOI: 10.5281/zenodo.5897277