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Comorbid Analysis of Neurodevelopmental Disorders and Epilepsy

Informations projet

N° de convention de subvention: 847818

État

Projet en cours

  • Date de début

    1 Janvier 2020

  • Date de fin

    31 Decembre 2024

Financé au titre de:

H2020-EU.3.1.1.

  • Budget total:

    € 6 000 000

  • Contribution de l’UE

    € 6 000 000

Coordonné par:

STICHTING KATHOLIEKE UNIVERSITEIT

Pays-Bas

Objectif

Neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), and intellectual disability (ID) are clinically heterogeneous, often co-occur, affect ~15% of the EU population; and are associated with somatic illnesses (e.g. epilepsy, autoimmune and gastrointestinal disease) that lead to a significant increase in morbidity and mortality. For instance in ASD the combination of ID and epilepsy is associated with a reduction in lifespan of ~ 20 years; and an economic cost that is greater than cancer, stroke, or dementia. Yet, the research spend on NDDs is less than 1% of those disorders. Hence, we lack effective new treatments for NDDs and do not understand why they co-occur. There is hope, however. Recent evidence shows that rare genetic variants increasing risk for NDDs are shared, converge on final common pathways (e.g. synaptic plasticity, glutamate and GABA neurotransmission, and excitation/inhibition imbalance), and a key role is likely played by immune dysregulation. CANDY’s innovation is to test, for the first time, if NDDs, and their common mental and somatic multimorbidity, are caused by a combination(s) of common and rare genetic variants and immune activation acting at different ‘sensitive periods’. Our multidisciplinary team of world leading academics, patient organizations and SMEs will cost-effectively leverage existing EU-funded studies to 1) identify novel mechanisms underpinning NDDs and their multimorbidity, 2) develop new strategies for prevention and treatment, 3) deliver novel biomarkers to guide early diagnosis, stratification and/or treatment monitoring, and 4) provide open-access data bases, translational test batteries, and tools and targets for valorization. Together we will transform the landscape for people with NDDs and make possible personalized medicine approaches that target particular mechanisms, in specific subgroups of individuals and at different life stages.

Programme(s)

H2020-EU.3.1.1. - Understanding health, wellbeing and disease

Thème(s)

SC1-BHC-01-2019 - Understanding causative mechanisms in co- and multimorbidities combining mental and non-mental disorders

Appel à propositions

H2020-SC1-2019-Two-Stage-RTD

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Régime de financement

RIA - Research and Innovation action
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinateur

STICHTING KATHOLIEKE UNIVERSITEIT

Adresse

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Pays-Bas

Type d’activité

Higher or Secondary Education Establishments

Contribution de l’UE

€ 1 615 000

Site web

Contacter l’organisation

Participants (15)

KING'S COLLEGE LONDON

Royaume-Uni

Contribution de l’UE

€ 825 000

INSTITUT PASTEUR

France

Contribution de l’UE

€ 425 000

UNIVERSITAT BASEL

Suisse

Contribution de l’UE

€ 250 000

RIJKSUNIVERSITEIT GRONINGEN

Pays-Bas

Contribution de l’UE

€ 250 000

UNIVERSITEIT GENT

Belgique

Contribution de l’UE

€ 300 000

KAROLINSKA INSTITUTET

Suède

Contribution de l’UE

€ 300 000

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

Contribution de l’UE

€ 300 000

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Contribution de l’UE

€ 350 000

UNIVERSITAET ULM

Allemagne

Contribution de l’UE

€ 150 000

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

Contribution de l’UE

€ 500 000

ADD INFORMATION SERVICES

Royaume-Uni

Contribution de l’UE

€ 30 000

AUTISME-EUROPE AISBL

Belgique

Contribution de l’UE

€ 30 000

NOLDUS INFORMATION TECHNOLOGY BV

Pays-Bas

Contribution de l’UE

€ 200 000

ARTTIC

France

Contribution de l’UE

€ 350 000

BIRKBECK COLLEGE - UNIVERSITY OF LONDON

Royaume-Uni

Contribution de l’UE

€ 125 000

Informations projet

N° de convention de subvention: 847818

État

Projet en cours

  • Date de début

    1 Janvier 2020

  • Date de fin

    31 Decembre 2024

Financé au titre de:

H2020-EU.3.1.1.

  • Budget total:

    € 6 000 000

  • Contribution de l’UE

    € 6 000 000

Coordonné par:

STICHTING KATHOLIEKE UNIVERSITEIT

Pays-Bas

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Dernière mise à jour: 19 Mars 2020

Numéro d’enregistrement: 226101