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Effective combinational treatment of chronic pain in individual patients, by an innovative quantitative systems pharmacology pain relief approach.

Deliverables

Go-online of the public project website

The public project website will serve several purposes, including a) being the central go-to-point for consortium members to look up contact information of other partners and to log into the confidential intranet, b) providing a concise overview of the project’s goals, its work packages, and the scientific background to the general public, and c) continuously informing patients and the general public on project-related events, publications, downloads and newsworthy developments. Patient-relevant information will be made available in several common EU languages.

Project brochure (for patients, laymen and scientists) and professional templates

The project brochure will be a handy flyer or folder that summarises the project’s vision, why it matters, its key objectives, the partner institutions, basic facts (start date, duration, number of countries, funding amount etc.) for transparency, the website URL, and contact information of the scientific coordinator and the project Manager.

Video

A video will be produced for the general public and patients (target audience) explaining the problem of chronic pain and the secondary problems, the lack of adequate treatment for many chronic pain patients, as well as the key goals of the QSPainRelief project in form of animated filmed interviews with the coordinator and WP leaders.

1st patient and layman event

Jointly with one of the relevant patient organisations, the first layman event will take place within the first 6 months, including a Q & A session at a convenient location (most likely connected to an SC Meeting) where partnering clinicians and researchers explain the scope of the project and answer questions of patients and the general public.

Publications

Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns

Author(s): Adrián Ricarte, James A. R. Dalton, Jesús Giraldo
Published in: Journal of Chemical Information and Modeling, Issue 61/3, 2021, Page(s) 1251-1274, ISSN 1549-9596
DOI: 10.1021/acs.jcim.0c00890

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors

Author(s): Pedro Renault, Jesús Giraldo
Published in: International Journal of Molecular Sciences, Issue 22/1, 2021, Page(s) 187, ISSN 1422-0067
DOI: 10.3390/ijms22010187

Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation

Author(s): Agustín Bruzzese, James A. R. Dalton, Jesús Giraldo
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-77072-4