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Effective combinational treatment of chronic pain in individual patients, by an innovative quantitative systems pharmacology pain relief approach.

Deliverables

Go-online of the public project website

The public project website will serve several purposes, including a) being the central go-to-point for consortium members to look up contact information of other partners and to log into the confidential intranet, b) providing a concise overview of the project’s goals, its work packages, and the scientific background to the general public, and c) continuously informing patients and the general public on project-related events, publications, downloads and newsworthy developments. Patient-relevant information will be made available in several common EU languages.

Project brochure (for patients, laymen and scientists) and professional templates

The project brochure will be a handy flyer or folder that summarises the project’s vision, why it matters, its key objectives, the partner institutions, basic facts (start date, duration, number of countries, funding amount etc.) for transparency, the website URL, and contact information of the scientific coordinator and the project Manager.

Video

A video will be produced for the general public and patients (target audience) explaining the problem of chronic pain and the secondary problems, the lack of adequate treatment for many chronic pain patients, as well as the key goals of the QSPainRelief project in form of animated filmed interviews with the coordinator and WP leaders.

1st patient and layman event

Jointly with one of the relevant patient organisations, the first layman event will take place within the first 6 months, including a Q & A session at a convenient location (most likely connected to an SC Meeting) where partnering clinicians and researchers explain the scope of the project and answer questions of patients and the general public.

Report on CNS drug distribution and target engagement profiles of all candidate drugs for augmentation strategies

Document identifying the selected drugs out of the list of EU approved medications their simulated CNS drug distribution and ontarget functional concentration derived from clinical studies

Publications

Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain

Author(s): David Cabañero, Beltrán Álvarez Pérez, Elena Martín-García, Rafael Maldonado
Published in: BIO-PROTOCOL, Issue 12, 2024, ISSN 2331-8325
Publisher: Bio-protocol
DOI: 10.21769/bioprotoc.4348

Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns

Author(s): Adrián Ricarte, James A. R. Dalton, Jesús Giraldo
Published in: Journal of Chemical Information and Modeling, Issue 61/3, 2021, Page(s) 1251-1274, ISSN 1549-9596
Publisher: American Chemical Society
DOI: 10.1021/acs.jcim.0c00890

Role of CB2 cannabinoid receptor in the development of food addiction in male mice

Author(s): A. García-Blanco, Á. Ramírez-López, F. Navarrete, M.S. García-Gutiérrez, J. Manzanares, E. Martín-García, R. Maldonado
Published in: Neurobiology of Disease, Issue 179, 2024, Page(s) 106034, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2023.106034

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors

Author(s): Pedro Renault, Jesús Giraldo
Published in: International Journal of Molecular Sciences, Issue 22/1, 2021, Page(s) 187, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010187

miRNA signatures associated with vulnerability to food addiction in mice and humans

Author(s): Alejandra García-Blanco, Laura Domingo-Rodriguez, Judit Cabana-Domínguez, Noèlia Fernández-Castillo, Laura Pineda-Cirera, Jordi Mayneris-Perxachs, Aurelijus Burokas, Jose Espinosa-Carrasco, Silvia Arboleya, Jessica Latorre, Catherine Stanton, Bru Cormand, Jose-Manuel Fernández-Real, Elena Martín-García, Rafael Maldonado
Published in: Journal of Clinical Investigation, Issue 132, 2023, ISSN 1558-8238
Publisher: The American Society for Clinical Investigation
DOI: 10.1172/jci156281

Presence of <i>Blastocystis</i> in gut microbiota is associated with cognitive traits and decreased executive function

Author(s): Jordi Mayneris-Perxachs, María Arnoriaga-Rodríguez, Josep Garre-Olmo, Josep Puig, Rafael Ramos, Maria Trelis, Aurelijus Burokas, Clàudia Coll, Cristina Zapata-Tona, Salvador Pedraza, Vicente Pérez-Brocal, Lluís Ramió, Wifredo Ricart, Andrés Moya, Mariona Jové, Joaquim Sol, Manuel Portero-Otin, Reinald Pamplona, Rafael Maldonado, José Manuel Fernández-Real
Published in: The ISME Journal, Issue 16, 2024, Page(s) 2181-2197, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-022-01262-3

Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation.

Author(s): Oscar Díaz, Pedro Renault, and Jesús Giraldo
Published in: ACS Omega, Issue 7, 42, 2022, Page(s) 37873–37884, ISSN 2470-1343
Publisher: American Chemical Society (ACS) Publications
DOI: 10.1021/acsomega.2c04980

Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice

Author(s): Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss-Schaap, Elizabeth C. M. de Lange
Published in: Pharmaceutical Research, Issue 40, 2023, Page(s) 2555-2566, ISSN 0724-8741
Publisher: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-023-03554-5

THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model

Author(s): María del Mar Cajiao-Manrique, Verònica Casadó-Anguera, Alejandra García-Blanco, Rafael Maldonado, Elena Martín-García
Published in: Frontiers in Psychiatry, Issue 14, 2023, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2023.1148993

Time-dependent ligand-receptor binding kinetics and functionality in a heterodimeric receptor model

Author(s): Antonio J. Ortiz, Víctor Martín, David Romero, Antoni Guillamon, Jesús Giraldo
Published in: Biochemical Pharmacology, Issue 225, 2024, Page(s) 116299, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2024.116299

Allosteric binding cooperativity in a kinetic context

Author(s): Óscar Díaz, Victor Martín, Pedro Renault, David Romero, Antoni Guillamon, Jesús Giraldo
Published in: Drug Discovery Today, Issue Volume 28, Issue 2, 2023, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2022.103441

Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation

Author(s): Agustín Bruzzese, James A. R. Dalton, Jesús Giraldo
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-77072-4

Dose determination of morphine to investigate the analgesic effects of morphine and pregabalin in healthy subjects using a combined NONMEM model

Author(s): Bertayli M,Hijma H, Bakker W, Groeneveld GJ, Elassaiss-Schaap S
Published in: PAGE. Abstracts of the Annual Meeting of the Population Approach Group in Europe., 2022
Publisher: Population Approach Group in Europe

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