Effective combinational treatment of chronic pain in individual patients, by an innovative quantitative systems pharmacology pain relief approach.

Informazioni relative al progetto

QSPainRelief

ID dell’accordo di sovvenzione: 848068

DOI

10.3030/848068

Progetto chiuso

Data della firma CE 13 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Giugno 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 239 539,25

Contributo UE

€ 6 239 538,75

Coordinato da

UNIVERSITEIT LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (2)

2nd patient and layman event

Jointly with one of the relevant patient organisations, the second layman event will take place before the end of the second year, including a Q & A session at a convenient location (most likely connected to a GA Meeting) where partnering clinicians and researchers explain the scope of the project, present most recent results, and answer questions of patients and the general public.

1st patient and layman event

Jointly with one of the relevant patient organisations, the first layman event will take place within the first 6 months, including a Q & A session at a convenient location (most likely connected to an SC Meeting) where partnering clinicians and researchers explain the scope of the project and answer questions of patients and the general public.

Websites, patent fillings, videos etc. (3)

Go-online of the public project website

The public project website will serve several purposes, including a) being the central go-to-point for consortium members to look up contact information of other partners and to log into the confidential intranet, b) providing a concise overview of the project’s goals, its work packages, and the scientific background to the general public, and c) continuously informing patients and the general public on project-related events, publications, downloads and newsworthy developments. Patient-relevant information will be made available in several common EU languages.

Project brochure (for patients, laymen and scientists) and professional templates

The project brochure will be a handy flyer or folder that summarises the project’s vision, why it matters, its key objectives, the partner institutions, basic facts (start date, duration, number of countries, funding amount etc.) for transparency, the website URL, and contact information of the scientific coordinator and the project Manager.

Video

A video will be produced for the general public and patients (target audience) explaining the problem of chronic pain and the secondary problems, the lack of adequate treatment for many chronic pain patients, as well as the key goals of the QSPainRelief project in form of animated filmed interviews with the coordinator and WP leaders.

Documents, reports (1)

Report on CNS drug distribution and target engagement profiles of all candidate drugs for augmentation strategies

Document identifying the selected drugs out of the list of EU approved medications their simulated CNS drug distribution and ontarget functional concentration derived from clinical studies

Pubblicazioni

Peer reviewed articles (23)

Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain

Autori: David Cabañero, Beltrán Álvarez Pérez, Elena Martín-García, Rafael Maldonado
Pubblicato in: BIO-PROTOCOL, Numero 12, 2024, ISSN 2331-8325
Editore: Bio-protocol
DOI: 10.21769/bioprotoc.4348

Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns

Autori: Adrián Ricarte, James A. R. Dalton, Jesús Giraldo
Pubblicato in: Journal of Chemical Information and Modeling, Numero 61/3, 2021, Pagina/e 1251-1274, ISSN 1549-9596
Editore: American Chemical Society
DOI: 10.1021/acs.jcim.0c00890

A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction

Autori: María del Mar Cajiao-Manrique, Rafael Maldonado, Elena Martín-García
Pubblicato in: Frontiers in Pharmacology, Numero 14, 2023, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1143365

Role of CB2 cannabinoid receptor in the development of food addiction in male mice

Autori: A. García-Blanco, Á. Ramírez-López, F. Navarrete, M.S. García-Gutiérrez, J. Manzanares, E. Martín-García, R. Maldonado
Pubblicato in: Neurobiology of Disease, Numero 179, 2024, Pagina/e 106034, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2023.106034

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors

Autori: Pedro Renault, Jesús Giraldo
Pubblicato in: International Journal of Molecular Sciences, Numero 22/1, 2021, Pagina/e 187, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010187

miRNA signatures associated with vulnerability to food addiction in mice and humans

Autori: Alejandra García-Blanco, Laura Domingo-Rodriguez, Judit Cabana-Domínguez, Noèlia Fernández-Castillo, Laura Pineda-Cirera, Jordi Mayneris-Perxachs, Aurelijus Burokas, Jose Espinosa-Carrasco, Silvia Arboleya, Jessica Latorre, Catherine Stanton, Bru Cormand, Jose-Manuel Fernández-Real, Elena Martín-García, Rafael Maldonado
Pubblicato in: Journal of Clinical Investigation, Numero 132, 2023, ISSN 1558-8238
Editore: The American Society for Clinical Investigation
DOI: 10.1172/jci156281

Presence of <i>Blastocystis</i> in gut microbiota is associated with cognitive traits and decreased executive function

Autori: Jordi Mayneris-Perxachs, María Arnoriaga-Rodríguez, Josep Garre-Olmo, Josep Puig, Rafael Ramos, Maria Trelis, Aurelijus Burokas, Clàudia Coll, Cristina Zapata-Tona, Salvador Pedraza, Vicente Pérez-Brocal, Lluís Ramió, Wifredo Ricart, Andrés Moya, Mariona Jové, Joaquim Sol, Manuel Portero-Otin, Reinald Pamplona, Rafael Maldonado, José Manuel Fernández-Real
Pubblicato in: The ISME Journal, Numero 16, 2024, Pagina/e 2181-2197, ISSN 1751-7362
Editore: Nature Publishing Group
DOI: 10.1038/s41396-022-01262-3

Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix

Autori: Divakar Budda, Berfin Gülave, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
Pubblicato in: British Journal of Pharmacology, 2024, ISSN 0007-1188
Editore: Wiley-Blackwell
DOI: 10.1111/bph.16394

Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?

Autori: Berfin Gülave, Ariel Lesmana, Elizabeth CM de Lange, JG Coen van Hasselt
Pubblicato in: Journal of Pharmacokinetics and Pharmacodynamics, Numero 52, 2025, ISSN 1567-567X
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10928-024-09957-0

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Autori: Berfin Gülave, Divakar Budda, Mohammed AA Saleh, JG Coen van Hasselt, Elizabeth CM de Lange
Pubblicato in: European Journal of Pharmaceutical Sciences, Numero 187, 2024, Pagina/e 106482, ISSN 0928-0987
Editore: Elsevier BV
DOI: 10.1016/j.ejps.2023.106482

Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis

Autori: Divakar Budda, Zhicheng Zhang, J.G. Coen van Hasselt, Elizabeth C.M. de Lange
Pubblicato in: European Journal of Pharmaceutical Sciences, Numero 212, 2025, Pagina/e 107195, ISSN 0928-0987
Editore: Elsevier BV
DOI: 10.1016/j.ejps.2025.107195

Preoperative susceptibility to developing secondary hyperalgesia is associated with post‐thoracotomy pain at 2 months

Autori: Solenn Gousset, Maximilien Cappe, Cedric Lenoir, Arnaud Steyaert, Patricia Lavand'homme, André Mouraux, Valérie Lacroix, Emanuel N. van den Broeke
Pubblicato in: European Journal of Pain, Numero 29, 2025, ISSN 1090-3801
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.4768

Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation.

Autori: Oscar Díaz, Pedro Renault, and Jesús Giraldo
Pubblicato in: ACS Omega, Numero 7, 42, 2022, Pagina/e 37873–37884, ISSN 2470-1343
Editore: American Chemical Society (ACS) Publications
DOI: 10.1021/acsomega.2c04980

Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice

Autori: Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss-Schaap, Elizabeth C. M. de Lange
Pubblicato in: Pharmaceutical Research, Numero 40, 2023, Pagina/e 2555-2566, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-023-03554-5

Navigating the biopsychosocial landscape: A systematic review on the association between social support and chronic pain

Autori: Carlo Matej Rinaudo, Maxim Van de Velde, Arnaud Steyaert, André Mouraux
Pubblicato in: PLOS One, Numero 20, 2025, Pagina/e e0321750, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0321750

Application of a Nociceptive Test Battery to Assess Potential Synergy between Two Analgesics in Healthy Subjects

Autori: Wouter Alexander Bakker, Monir Bertayli, Daniël Benjamin Dumas, Jeroen Elassaiss-Schaap, Maria Joanna Juachon, Karen Broekhuizen, Hemme Jacob Hijma, Geert Jan Groeneveld
Pubblicato in: ACS Pharmacology &amp; Translational Science, Numero 8, 2025, Pagina/e 819-830, ISSN 2575-9108
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsptsci.4c00696

THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model

Autori: María del Mar Cajiao-Manrique, Verònica Casadó-Anguera, Alejandra García-Blanco, Rafael Maldonado, Elena Martín-García
Pubblicato in: Frontiers in Psychiatry, Numero 14, 2023, ISSN 1664-0640
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2023.1148993

Time-dependent ligand-receptor binding kinetics and functionality in a heterodimeric receptor model

Autori: Antonio J. Ortiz, Víctor Martín, David Romero, Antoni Guillamon, Jesús Giraldo
Pubblicato in: Biochemical Pharmacology, Numero 225, 2024, Pagina/e 116299, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2024.116299

Allosteric binding cooperativity in a kinetic context

Autori: Óscar Díaz, Victor Martín, Pedro Renault, David Romero, Antoni Guillamon, Jesús Giraldo
Pubblicato in: Drug Discovery Today, Numero Volume 28, Numero 2, 2023, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2022.103441

Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?

Autori: Berfin Gülave; Divakar Budda; Mohammed AA Saleh; JG Coen van Hasselt; Elizabeth CM de Lange
Pubblicato in: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editore: Elsevier BV
DOI: 10.1101/2023.03.17.533135

Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Autori: Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange
Pubblicato in: Journal of Pharmacokinetics and Pharmacodynamics, Numero 52, 2025, ISSN 1567-567X
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10928-025-09963-w

Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation

Autori: Agustín Bruzzese, James A. R. Dalton, Jesús Giraldo
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-77072-4

Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model

Autori: Berfin Gülave, Helle W. van den Maagdenberg, Luke van Boven, Gerard J. P. van Westen, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
Pubblicato in: Pharmaceutical Research, Numero 42, 2025, Pagina/e 281-289, ISSN 0724-8741
Editore: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-025-03828-0

Conference proceedings (1)

PK-PD model of morphine, pregabalin and their combination to assess the opioid-sparing effect

Autori: Monir Bertayli, Wouter Bakker, Geert Jan Groeneveld, Jeroen Elassaiss-Schaap
Pubblicato in: Poster Abstract, 2024
Editore: PAGE

Thesis and dissertations (1)

Novel approaches to investigate central sensitization : from experimental models to clinical perspectives

Autori: Gousset, Solenn
Pubblicato in: DIAL.pr Research Publications, 2025
Editore: UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience