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CORDIS - Resultados de investigaciones de la UE
CORDIS

Effective combinational treatment of chronic pain in individual patients, by an innovative quantitative systems pharmacology pain relief approach.

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

2nd patient and layman event (se abrirá en una nueva ventana)

Jointly with one of the relevant patient organisations, the second layman event will take place before the end of the second year, including a Q & A session at a convenient location (most likely connected to a GA Meeting) where partnering clinicians and researchers explain the scope of the project, present most recent results, and answer questions of patients and the general public.

1st patient and layman event (se abrirá en una nueva ventana)

Jointly with one of the relevant patient organisations, the first layman event will take place within the first 6 months, including a Q & A session at a convenient location (most likely connected to an SC Meeting) where partnering clinicians and researchers explain the scope of the project and answer questions of patients and the general public.

Go-online of the public project website (se abrirá en una nueva ventana)

The public project website will serve several purposes, including a) being the central go-to-point for consortium members to look up contact information of other partners and to log into the confidential intranet, b) providing a concise overview of the project’s goals, its work packages, and the scientific background to the general public, and c) continuously informing patients and the general public on project-related events, publications, downloads and newsworthy developments. Patient-relevant information will be made available in several common EU languages.

Project brochure (for patients, laymen and scientists) and professional templates (se abrirá en una nueva ventana)

The project brochure will be a handy flyer or folder that summarises the project’s vision, why it matters, its key objectives, the partner institutions, basic facts (start date, duration, number of countries, funding amount etc.) for transparency, the website URL, and contact information of the scientific coordinator and the project Manager.

Video (se abrirá en una nueva ventana)

A video will be produced for the general public and patients (target audience) explaining the problem of chronic pain and the secondary problems, the lack of adequate treatment for many chronic pain patients, as well as the key goals of the QSPainRelief project in form of animated filmed interviews with the coordinator and WP leaders.

Report on CNS drug distribution and target engagement profiles of all candidate drugs for augmentation strategies (se abrirá en una nueva ventana)

Document identifying the selected drugs out of the list of EU approved medications their simulated CNS drug distribution and ontarget functional concentration derived from clinical studies

Publicaciones

Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain (se abrirá en una nueva ventana)

Autores: David Cabañero, Beltrán Álvarez Pérez, Elena Martín-García, Rafael Maldonado
Publicado en: BIO-PROTOCOL, Edición 12, 2024, ISSN 2331-8325
Editor: Bio-protocol
DOI: 10.21769/bioprotoc.4348

Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns (se abrirá en una nueva ventana)

Autores: Adrián Ricarte, James A. R. Dalton, Jesús Giraldo
Publicado en: Journal of Chemical Information and Modeling, Edición 61/3, 2021, Página(s) 1251-1274, ISSN 1549-9596
Editor: American Chemical Society
DOI: 10.1021/acs.jcim.0c00890

A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction (se abrirá en una nueva ventana)

Autores: María del Mar Cajiao-Manrique, Rafael Maldonado, Elena Martín-García
Publicado en: Frontiers in Pharmacology, Edición 14, 2023, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1143365

Role of CB2 cannabinoid receptor in the development of food addiction in male mice (se abrirá en una nueva ventana)

Autores: A. García-Blanco, Á. Ramírez-López, F. Navarrete, M.S. García-Gutiérrez, J. Manzanares, E. Martín-García, R. Maldonado
Publicado en: Neurobiology of Disease, Edición 179, 2024, Página(s) 106034, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2023.106034

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors (se abrirá en una nueva ventana)

Autores: Pedro Renault, Jesús Giraldo
Publicado en: International Journal of Molecular Sciences, Edición 22/1, 2021, Página(s) 187, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010187

miRNA signatures associated with vulnerability to food addiction in mice and humans (se abrirá en una nueva ventana)

Autores: Alejandra García-Blanco, Laura Domingo-Rodriguez, Judit Cabana-Domínguez, Noèlia Fernández-Castillo, Laura Pineda-Cirera, Jordi Mayneris-Perxachs, Aurelijus Burokas, Jose Espinosa-Carrasco, Silvia Arboleya, Jessica Latorre, Catherine Stanton, Bru Cormand, Jose-Manuel Fernández-Real, Elena Martín-García, Rafael Maldonado
Publicado en: Journal of Clinical Investigation, Edición 132, 2023, ISSN 1558-8238
Editor: The American Society for Clinical Investigation
DOI: 10.1172/jci156281

Presence of <i>Blastocystis</i> in gut microbiota is associated with cognitive traits and decreased executive function (se abrirá en una nueva ventana)

Autores: Jordi Mayneris-Perxachs, María Arnoriaga-Rodríguez, Josep Garre-Olmo, Josep Puig, Rafael Ramos, Maria Trelis, Aurelijus Burokas, Clàudia Coll, Cristina Zapata-Tona, Salvador Pedraza, Vicente Pérez-Brocal, Lluís Ramió, Wifredo Ricart, Andrés Moya, Mariona Jové, Joaquim Sol, Manuel Portero-Otin, Reinald Pamplona, Rafael Maldonado, José Manuel Fernández-Real
Publicado en: The ISME Journal, Edición 16, 2024, Página(s) 2181-2197, ISSN 1751-7362
Editor: Nature Publishing Group
DOI: 10.1038/s41396-022-01262-3

Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix (se abrirá en una nueva ventana)

Autores: Divakar Budda, Berfin Gülave, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
Publicado en: British Journal of Pharmacology, 2024, ISSN 0007-1188
Editor: Wiley-Blackwell
DOI: 10.1111/bph.16394

Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution? (se abrirá en una nueva ventana)

Autores: Berfin Gülave, Ariel Lesmana, Elizabeth CM de Lange, JG Coen van Hasselt
Publicado en: Journal of Pharmacokinetics and Pharmacodynamics, Edición 52, 2025, ISSN 1567-567X
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10928-024-09957-0

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies? (se abrirá en una nueva ventana)

Autores: Berfin Gülave, Divakar Budda, Mohammed AA Saleh, JG Coen van Hasselt, Elizabeth CM de Lange
Publicado en: European Journal of Pharmaceutical Sciences, Edición 187, 2024, Página(s) 106482, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2023.106482

Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis (se abrirá en una nueva ventana)

Autores: Divakar Budda, Zhicheng Zhang, J.G. Coen van Hasselt, Elizabeth C.M. de Lange
Publicado en: European Journal of Pharmaceutical Sciences, Edición 212, 2025, Página(s) 107195, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2025.107195

Preoperative susceptibility to developing secondary hyperalgesia is associated with post‐thoracotomy pain at 2 months (se abrirá en una nueva ventana)

Autores: Solenn Gousset, Maximilien Cappe, Cedric Lenoir, Arnaud Steyaert, Patricia Lavand'homme, André Mouraux, Valérie Lacroix, Emanuel N. van den Broeke
Publicado en: European Journal of Pain, Edición 29, 2025, ISSN 1090-3801
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.4768

Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation. (se abrirá en una nueva ventana)

Autores: Oscar Díaz, Pedro Renault, and Jesús Giraldo
Publicado en: ACS Omega, Edición 7, 42, 2022, Página(s) 37873–37884, ISSN 2470-1343
Editor: American Chemical Society (ACS) Publications
DOI: 10.1021/acsomega.2c04980

Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice (se abrirá en una nueva ventana)

Autores: Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss-Schaap, Elizabeth C. M. de Lange
Publicado en: Pharmaceutical Research, Edición 40, 2023, Página(s) 2555-2566, ISSN 0724-8741
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-023-03554-5

Navigating the biopsychosocial landscape: A systematic review on the association between social support and chronic pain (se abrirá en una nueva ventana)

Autores: Carlo Matej Rinaudo, Maxim Van de Velde, Arnaud Steyaert, André Mouraux
Publicado en: PLOS One, Edición 20, 2025, Página(s) e0321750, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0321750

Application of a Nociceptive Test Battery to Assess Potential Synergy between Two Analgesics in Healthy Subjects (se abrirá en una nueva ventana)

Autores: Wouter Alexander Bakker, Monir Bertayli, Daniël Benjamin Dumas, Jeroen Elassaiss-Schaap, Maria Joanna Juachon, Karen Broekhuizen, Hemme Jacob Hijma, Geert Jan Groeneveld
Publicado en: ACS Pharmacology &amp; Translational Science, Edición 8, 2025, Página(s) 819-830, ISSN 2575-9108
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsptsci.4c00696

THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model (se abrirá en una nueva ventana)

Autores: María del Mar Cajiao-Manrique, Verònica Casadó-Anguera, Alejandra García-Blanco, Rafael Maldonado, Elena Martín-García
Publicado en: Frontiers in Psychiatry, Edición 14, 2023, ISSN 1664-0640
Editor: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2023.1148993

Time-dependent ligand-receptor binding kinetics and functionality in a heterodimeric receptor model (se abrirá en una nueva ventana)

Autores: Antonio J. Ortiz, Víctor Martín, David Romero, Antoni Guillamon, Jesús Giraldo
Publicado en: Biochemical Pharmacology, Edición 225, 2024, Página(s) 116299, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2024.116299

Allosteric binding cooperativity in a kinetic context (se abrirá en una nueva ventana)

Autores: Óscar Díaz, Victor Martín, Pedro Renault, David Romero, Antoni Guillamon, Jesús Giraldo
Publicado en: Drug Discovery Today, Edición Volume 28, Edición 2, 2023, ISSN 1359-6446
Editor: Elsevier BV
DOI: 10.1016/j.drudis.2022.103441

Does nonlinear blood-brain barrier transport matter for morphine dosing strategies? (se abrirá en una nueva ventana)

Autores: Berfin Gülave; Divakar Budda; Mohammed AA Saleh; JG Coen van Hasselt; Elizabeth CM de Lange
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1101/2023.03.17.533135

Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly? (se abrirá en una nueva ventana)

Autores: Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange
Publicado en: Journal of Pharmacokinetics and Pharmacodynamics, Edición 52, 2025, ISSN 1567-567X
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10928-025-09963-w

Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation (se abrirá en una nueva ventana)

Autores: Agustín Bruzzese, James A. R. Dalton, Jesús Giraldo
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-77072-4

Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model (se abrirá en una nueva ventana)

Autores: Berfin Gülave, Helle W. van den Maagdenberg, Luke van Boven, Gerard J. P. van Westen, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
Publicado en: Pharmaceutical Research, Edición 42, 2025, Página(s) 281-289, ISSN 0724-8741
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-025-03828-0

PK-PD model of morphine, pregabalin and their combination to assess the opioid-sparing effect

Autores: Monir Bertayli, Wouter Bakker, Geert Jan Groeneveld, Jeroen Elassaiss-Schaap
Publicado en: Poster Abstract, 2024
Editor: PAGE

Novel approaches to investigate central sensitization : from experimental models to clinical perspectives

Autores: Gousset, Solenn
Publicado en: DIAL.pr Research Publications, 2025
Editor: UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience

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