Effective combinational treatment of chronic pain in individual patients, by an innovative quantitative systems pharmacology pain relief approach.

Informations projet

QSPainRelief

N° de convention de subvention: 848068

DOI

10.3030/848068

Projet clôturé

Date de signature de la CE 13 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 30 Juin 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 239 539,25

Contribution de l’UE

€ 6 239 538,75

Coordonné par

UNIVERSITEIT LEIDEN
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Other (2)

2nd patient and layman event

Jointly with one of the relevant patient organisations, the second layman event will take place before the end of the second year, including a Q & A session at a convenient location (most likely connected to a GA Meeting) where partnering clinicians and researchers explain the scope of the project, present most recent results, and answer questions of patients and the general public.

1st patient and layman event

Jointly with one of the relevant patient organisations, the first layman event will take place within the first 6 months, including a Q & A session at a convenient location (most likely connected to an SC Meeting) where partnering clinicians and researchers explain the scope of the project and answer questions of patients and the general public.

Websites, patent fillings, videos etc. (3)

Go-online of the public project website

The public project website will serve several purposes, including a) being the central go-to-point for consortium members to look up contact information of other partners and to log into the confidential intranet, b) providing a concise overview of the project’s goals, its work packages, and the scientific background to the general public, and c) continuously informing patients and the general public on project-related events, publications, downloads and newsworthy developments. Patient-relevant information will be made available in several common EU languages.

Project brochure (for patients, laymen and scientists) and professional templates

The project brochure will be a handy flyer or folder that summarises the project’s vision, why it matters, its key objectives, the partner institutions, basic facts (start date, duration, number of countries, funding amount etc.) for transparency, the website URL, and contact information of the scientific coordinator and the project Manager.

Video

A video will be produced for the general public and patients (target audience) explaining the problem of chronic pain and the secondary problems, the lack of adequate treatment for many chronic pain patients, as well as the key goals of the QSPainRelief project in form of animated filmed interviews with the coordinator and WP leaders.

Documents, reports (1)

Report on CNS drug distribution and target engagement profiles of all candidate drugs for augmentation strategies

Document identifying the selected drugs out of the list of EU approved medications their simulated CNS drug distribution and ontarget functional concentration derived from clinical studies

Publications

Peer reviewed articles (23)

Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain

Auteurs: David Cabañero, Beltrán Álvarez Pérez, Elena Martín-García, Rafael Maldonado
Publié dans: BIO-PROTOCOL, Numéro 12, 2024, ISSN 2331-8325
Éditeur: Bio-protocol
DOI: 10.21769/bioprotoc.4348

Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns

Auteurs: Adrián Ricarte, James A. R. Dalton, Jesús Giraldo
Publié dans: Journal of Chemical Information and Modeling, Numéro 61/3, 2021, Page(s) 1251-1274, ISSN 1549-9596
Éditeur: American Chemical Society
DOI: 10.1021/acs.jcim.0c00890

A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction

Auteurs: María del Mar Cajiao-Manrique, Rafael Maldonado, Elena Martín-García
Publié dans: Frontiers in Pharmacology, Numéro 14, 2023, ISSN 1663-9812
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1143365

Role of CB2 cannabinoid receptor in the development of food addiction in male mice

Auteurs: A. García-Blanco, Á. Ramírez-López, F. Navarrete, M.S. García-Gutiérrez, J. Manzanares, E. Martín-García, R. Maldonado
Publié dans: Neurobiology of Disease, Numéro 179, 2024, Page(s) 106034, ISSN 0969-9961
Éditeur: Academic Press
DOI: 10.1016/j.nbd.2023.106034

Dynamical Correlations Reveal Allosteric Sites in G Protein-Coupled Receptors

Auteurs: Pedro Renault, Jesús Giraldo
Publié dans: International Journal of Molecular Sciences, Numéro 22/1, 2021, Page(s) 187, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22010187

miRNA signatures associated with vulnerability to food addiction in mice and humans

Auteurs: Alejandra García-Blanco, Laura Domingo-Rodriguez, Judit Cabana-Domínguez, Noèlia Fernández-Castillo, Laura Pineda-Cirera, Jordi Mayneris-Perxachs, Aurelijus Burokas, Jose Espinosa-Carrasco, Silvia Arboleya, Jessica Latorre, Catherine Stanton, Bru Cormand, Jose-Manuel Fernández-Real, Elena Martín-García, Rafael Maldonado
Publié dans: Journal of Clinical Investigation, Numéro 132, 2023, ISSN 1558-8238
Éditeur: The American Society for Clinical Investigation
DOI: 10.1172/jci156281

Presence of <i>Blastocystis</i> in gut microbiota is associated with cognitive traits and decreased executive function

Auteurs: Jordi Mayneris-Perxachs, María Arnoriaga-Rodríguez, Josep Garre-Olmo, Josep Puig, Rafael Ramos, Maria Trelis, Aurelijus Burokas, Clàudia Coll, Cristina Zapata-Tona, Salvador Pedraza, Vicente Pérez-Brocal, Lluís Ramió, Wifredo Ricart, Andrés Moya, Mariona Jové, Joaquim Sol, Manuel Portero-Otin, Reinald Pamplona, Rafael Maldonado, José Manuel Fernández-Real
Publié dans: The ISME Journal, Numéro 16, 2024, Page(s) 2181-2197, ISSN 1751-7362
Éditeur: Nature Publishing Group
DOI: 10.1038/s41396-022-01262-3

Non‐linear blood–brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix

Auteurs: Divakar Budda, Berfin Gülave, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
Publié dans: British Journal of Pharmacology, 2024, ISSN 0007-1188
Éditeur: Wiley-Blackwell
DOI: 10.1111/bph.16394

Do P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier impact morphine brain distribution?

Auteurs: Berfin Gülave, Ariel Lesmana, Elizabeth CM de Lange, JG Coen van Hasselt
Publié dans: Journal of Pharmacokinetics and Pharmacodynamics, Numéro 52, 2025, ISSN 1567-567X
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10928-024-09957-0

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Auteurs: Berfin Gülave, Divakar Budda, Mohammed AA Saleh, JG Coen van Hasselt, Elizabeth CM de Lange
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 187, 2024, Page(s) 106482, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2023.106482

Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis

Auteurs: Divakar Budda, Zhicheng Zhang, J.G. Coen van Hasselt, Elizabeth C.M. de Lange
Publié dans: European Journal of Pharmaceutical Sciences, Numéro 212, 2025, Page(s) 107195, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1016/j.ejps.2025.107195

Preoperative susceptibility to developing secondary hyperalgesia is associated with post‐thoracotomy pain at 2 months

Auteurs: Solenn Gousset, Maximilien Cappe, Cedric Lenoir, Arnaud Steyaert, Patricia Lavand'homme, André Mouraux, Valérie Lacroix, Emanuel N. van den Broeke
Publié dans: European Journal of Pain, Numéro 29, 2025, ISSN 1090-3801
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1002/ejp.4768

Evaluating Allosteric Perturbations in Cannabinoid Receptor 1 by In Silico Single-Point Mutation.

Auteurs: Oscar Díaz, Pedro Renault, and Jesús Giraldo
Publié dans: ACS Omega, Numéro 7, 42, 2022, Page(s) 37873–37884, ISSN 2470-1343
Éditeur: American Chemical Society (ACS) Publications
DOI: 10.1021/acsomega.2c04980

Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice

Auteurs: Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss-Schaap, Elizabeth C. M. de Lange
Publié dans: Pharmaceutical Research, Numéro 40, 2023, Page(s) 2555-2566, ISSN 0724-8741
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-023-03554-5

Navigating the biopsychosocial landscape: A systematic review on the association between social support and chronic pain

Auteurs: Carlo Matej Rinaudo, Maxim Van de Velde, Arnaud Steyaert, André Mouraux
Publié dans: PLOS One, Numéro 20, 2025, Page(s) e0321750, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0321750

Application of a Nociceptive Test Battery to Assess Potential Synergy between Two Analgesics in Healthy Subjects

Auteurs: Wouter Alexander Bakker, Monir Bertayli, Daniël Benjamin Dumas, Jeroen Elassaiss-Schaap, Maria Joanna Juachon, Karen Broekhuizen, Hemme Jacob Hijma, Geert Jan Groeneveld
Publié dans: ACS Pharmacology &amp; Translational Science, Numéro 8, 2025, Page(s) 819-830, ISSN 2575-9108
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/acsptsci.4c00696

THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model

Auteurs: María del Mar Cajiao-Manrique, Verònica Casadó-Anguera, Alejandra García-Blanco, Rafael Maldonado, Elena Martín-García
Publié dans: Frontiers in Psychiatry, Numéro 14, 2023, ISSN 1664-0640
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2023.1148993

Time-dependent ligand-receptor binding kinetics and functionality in a heterodimeric receptor model

Auteurs: Antonio J. Ortiz, Víctor Martín, David Romero, Antoni Guillamon, Jesús Giraldo
Publié dans: Biochemical Pharmacology, Numéro 225, 2024, Page(s) 116299, ISSN 0006-2952
Éditeur: Elsevier BV
DOI: 10.1016/j.bcp.2024.116299

Allosteric binding cooperativity in a kinetic context

Auteurs: Óscar Díaz, Victor Martín, Pedro Renault, David Romero, Antoni Guillamon, Jesús Giraldo
Publié dans: Drug Discovery Today, Numéro Volume 28, Numéro 2, 2023, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.1016/j.drudis.2022.103441

Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?

Auteurs: Berfin Gülave; Divakar Budda; Mohammed AA Saleh; JG Coen van Hasselt; Elizabeth CM de Lange
Publié dans: European Journal of Pharmaceutical Sciences, 2023, ISSN 0928-0987
Éditeur: Elsevier BV
DOI: 10.1101/2023.03.17.533135

Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Auteurs: Daan W. van Valkengoed, Makoto Hirasawa, Vivi Rottschäfer, Elizabeth C. M. de Lange
Publié dans: Journal of Pharmacokinetics and Pharmacodynamics, Numéro 52, 2025, ISSN 1567-567X
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10928-025-09963-w

Statistics for the analysis of molecular dynamics simulations: providing P values for agonist-dependent GPCR activation

Auteurs: Agustín Bruzzese, James A. R. Dalton, Jesús Giraldo
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-77072-4

Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model

Auteurs: Berfin Gülave, Helle W. van den Maagdenberg, Luke van Boven, Gerard J. P. van Westen, Elizabeth C. M. de Lange, J. G. Coen van Hasselt
Publié dans: Pharmaceutical Research, Numéro 42, 2025, Page(s) 281-289, ISSN 0724-8741
Éditeur: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s11095-025-03828-0

Conference proceedings (1)

PK-PD model of morphine, pregabalin and their combination to assess the opioid-sparing effect

Auteurs: Monir Bertayli, Wouter Bakker, Geert Jan Groeneveld, Jeroen Elassaiss-Schaap
Publié dans: Poster Abstract, 2024
Éditeur: PAGE

Thesis and dissertations (1)

Novel approaches to investigate central sensitization : from experimental models to clinical perspectives

Auteurs: Gousset, Solenn
Publié dans: DIAL.pr Research Publications, 2025
Éditeur: UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience