Effective combinational treatment of chronic pain in individual patients, by an innovative quantitative systems pharmacology pain relief approach.

Project description

New way to fight chronic pain

Chronic pain is pain that lasts a long time, even after an injury heals. It affects more than 20 % of the population causing problems in everyday life. Chronic pain is treated with a combination of several analgesic drugs administered according to each physician’s decision based on their own best experiences. This is often not effective and it could even cause harmful effects. The EU-funded QSPainRelief project will develop a platform to improve treatment and relieve chronic pain with an effective combination of drugs thanks to a mechanism of quantitative systems pharmacology based on mathematical modelling (in silico modelling). It will allow physicians to identify and test effective, personally targeted therapy through the smart combination of drugs for each patient case.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmacokinetics

Programme(s)

• H2020-EU.3.1.1. - Understanding health, wellbeing and disease

Topic(s)

• SC1-BHC-02-2019 - Systems approaches for the discovery of combinatorial therapies for complex disorders

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITEIT LEIDEN

Address

Rapenburg 70
2311 EZ Leiden
Netherlands

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 404 207,50

Participants (9)

IN SILICO BIOSCIENCES, INC

United States

EU contribution

€ 1 095 875

Address

405 Waltham Street
02421 Lexington Ma

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

PD-VALUE BV

Netherlands

EU contribution

€ 298 375

Address

Molenaarserf 102
3991 KT Houten

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Concentris Research Management GmbH

Germany

EU contribution

€ 530 000

Address

Ludwigstr. 4
D-82256 Fürstenfeldbruck

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

UNIVERSIDAD AUTONOMA DE BARCELONA

Spain

EU contribution

€ 340 875

Address

Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles

Activity type

Higher or Secondary Education Establishments

UNIVERSIDAD POMPEU FABRA

Spain

EU contribution

€ 585 875

Address

Placa De La Merce, 10-12
08002 Barcelona

Activity type

Higher or Secondary Education Establishments

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU contribution

€ 390 875

Address

Via Zamboni 33
40126 Bologna

Activity type

Higher or Secondary Education Establishments

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU contribution

€ 848 320

Address

Place De L Universite 1
1348 Louvain La Neuve

Activity type

Higher or Secondary Education Establishments

STICHTING CENTRE FOR HUMAN DRUG RESEARCH

Netherlands

EU contribution

€ 677 636,25

Address

Zernikedreef 8
2333 CL Leiden

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

CLINIQUES UNIVERSITAIRES SAINT-LUC

Belgium

EU contribution

€ 67 500

Address

Avenue Hippocrate 10
1200 Bruxelles

Activity type

Research Organisations