MiCrovasculaR rarefaction in vascUlar Cognitive Impairement and heArt faiLure

Project Information

CRUCIAL

Grant agreement ID: 848109

DOI

10.3030/848109

Project closed

EC signature date 6 December 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 000 000,00

EU contribution

€ 6 000 000,00

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (2)

Website and twitter account

Launch of website and twitter account

Communication Strategy

Communication Strategy - Initial strategy will be produced by the 6 month deadline. The strategy will be updated at the Periodic Reporting M18. A final communication strategy will be produced for M36.

Other (1)

Microvascular Helix

Publications

Peer reviewed articles (37)

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Author(s): Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones
Published in: Cardiovascular Diabetology, Issue 24, 2025, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-025-02623-w

Vessel Enlargement in Development and Pathophysiology

Author(s): Laia Gifre-Renom, Elizabeth A. V. Jones
Published in: Frontiers in Physiology, Issue 12, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.639645

Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems

Author(s): Kristof Van Schoor, Emmanuel Bruet, Elizabeth Anne Vincent Jones, Isabelle Migeotte
Published in: Frontiers in Physiology, Issue 15, 2024, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2024.1395006

CCR2⁺ monocyte-derived macrophages drive cardiac hypertrophy in early HFpEF

Author(s): Jana Raman, Steven Simmonds, Ellen Caluwé, Rick van Leeuwen, Caroline Walschap, Mathias Stroobants, Ümare Cöl, Petra Vandervoort, Stephane Heymans, Elizabeth A. V. Jones
Published in: American Journal of Physiology-Heart and Circulatory Physiology, Issue 329, 2025, Page(s) H109-H123, ISSN 0363-6135
Publisher: American Physiological Society
DOI: 10.1152/ajpheart.00022.2025

Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure

Author(s): Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z, Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal MA, Gordon DA, Ramirez-Valle F, Cappola TP
Published in: NEJM Evidence, 2022, ISSN 2766-5526
Publisher: /
DOI: 10.1056/evidx2200258

Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study

Author(s): van Dinther M, Schram MT, Jansen JFA, Backes WH, Houben AJHM, Berendschot TTJM, Schalkwijk CG, Stehouwer CDA, van Oostenbrugge RJ, Staals J.
Published in: Geroscience, 2022, ISSN 2509-2723
Publisher: /
DOI: 10.1007/s11357-021-00493-0

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis

Author(s): Ebba Brakenhielm, Arantxa González, Javier Díez
Published in: Journal of the American College of Cardiology, Issue 76/6, 2020, Page(s) 735-744, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2020.05.076

Vessel architecture imaging reveals microvascular rarefaction and capillary-to-arteriole shift in cerebral small vessel disease

Author(s): Paulien HM Voorter, Maud van Dinther, Gerhard S Drenthen, Elles P Elschot, Julie Staals, Robert J van Oostenbrugge, Jacobus FA Jansen, Walter H Backes, null null
Published in: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251358968

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA

Author(s): Aghagolzadeh P, Plaisance I, Bernasconi R, Treibel TA, Pulido Quetglas C, Wyss T, Wigger L, Nemir M, Sarre A, Chouvardas P, Johnson R, González A, Pedrazzini T
Published in: Circulation, Issue Aug 29;148(9), 2023, Page(s) 778-797, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.062601

Fluid flow as a driver of embryonic morphogenesis

Author(s): Margo Daems, Hanna M. Peacock, Elizabeth A. V. Jones
Published in: Development, Issue 147/15, 2020, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.185579

The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model

Author(s): Ilona Cuijpers, Paolo Carai, Pedro Mendes-Ferreira, Steven J. Simmonds, Paul Mulder, Daniela Miranda-Silva, Daria De Giorgio, Peter Pokreisz, Stephane Heymans, Elizabeth A. V. Jones
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-72924-5

Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging

Author(s): van Dinther M, Voorter PH, Jansen JF, Jones EA, van Oostenbrugge RJ, Staals J, Backes WH
Published in: J Cereb Blood Flow Metab, 2022, ISSN 1559-7016
Publisher: /
DOI: 10.1177/0271678x221076557

SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19

Author(s): Daems M, Liesenborghs L, Boudewijns R, Simmonds SJ, Kraisin S, Van Wauwe J, Cuijpers I, Raman J, Geuens N, Buyten TV, Lox M, Verhamme P, Van Linthout S, Martinod K, Heymans S, Tschöpe C, Neyts J, Jones EAV
Published in: Front Cardiovasc Med, 2022, ISSN 2297-055X
Publisher: /
DOI: 10.3389/fcvm.2022.964512

Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study

Author(s): Marieke van den Kerkhof, Joost J.A. de Jong, Paulien H.M. Voorter, Alida A. Postma, Abraham A. Kroon, Robert J. van Oostenbrugge, Jacobus F.A. Jansen, Walter H. Backes
Published in: Hypertension, Issue 81, 2025, Page(s) 2162-2172, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.22617

Management of cardiac fibrosis is the largest unmet medical need in heart failure

Author(s): Javier Díez, Rudolf A de Boer
Published in: Cardiovascular Research, 2021, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab228

Safety of ward-based, non-physician-led, cardiac monitor implantation

Author(s): William T.C. Procter, Jonathan Bennett, James Elliott, Rok Mravljak, George D. Thornton, Nikoo Aziminia, Francisco Gama, Christian Nitsche, Zoe Carter, Jincymol Binoy, Christopher Monkhouse, Mark Earley, Ross J. Hunter, Thomas A. Treibel
Published in: Heart Rhythm, Issue 22, 2025, Page(s) 271-272, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.07.003

Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease`

Author(s): Paulien H. M. Voorter, Walter H. Backes, Oliver J. Gurney-Champion, Sau-May Wong, Julie Staals, Robert J. van Oostenbrugge, Merel M. van der Thiel, Jacobus F. A. Jansen, Gerhard S. Drenthen
Published in: Magnetic Resonance in Medicine``, 2023, ISSN 1522-2594
Publisher: International Society for Magnetic Resonance in Medicine
DOI: 10.1002/mrm.29753

Diffusion‐derived intravoxel‐incoherent motion anisotropy relates to CSF and blood flow

Author(s): Paulien H. M. Voorter, Jacobus F. A. Jansen, Merel M. van der Thiel, Maud van Dinther, Alida A. Postma, Robert J. van Oostenbrugge, Oliver J. Gurney‐Champion, Gerhard S. Drenthen, Walter H. Backes
Published in: Magnetic Resonance in Medicine, Issue 93, 2024, Page(s) 930-941, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.30294

Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI

Author(s): van Dinther M, Voorter PHM, Schram MT, Berendschot TTJM, Houben AJHM, Webers CAB, van Oostenbrugge RJ, Backes WH, Staals J, Jansen JFA
Published in: J Neurol Sci, 2022, ISSN 0022-510X
Publisher: Elsevier BV
DOI: 10.1016/j.jns.2022.120359

Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations

Author(s): Bram Callewaert, Elizabeth A. V. Jones, Uwe Himmelreich, Willy Gsell
Published in: Diagnostics, Issue 11/6, 2021, Page(s) 926, ISSN 2075-4418
Publisher: /
DOI: 10.3390/diagnostics11060926

EvaluationofMicrovascularRarefactionin VascularCognitiveImpairmentandHeart Failure(CRUCIAL):StudyProtocolforan ObservationalStudy

Author(s): Maud van Dinther, Jonathan Bennett, George D. Thornton, Paulien H.M. Voorter, Ana Ezponda Casajús, Alun Hughes, Gabriella Captur, Robert J. Holtackers, CRUCIAL Consortium Clinical Members, Julie Staals, Walter H. Backes, Gorka Bastarika, Elizabeth A.V. Jones, Arantxa González, Robert J. van Oostenbrugge, Thomas Alexander Treibel
Published in: Cerebrovasc Dis Extra, Issue 13(1), 2023, Page(s) 18-32, ISSN 1664-5456
Publisher: Karger
DOI: 10.1159/000529067

Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment

Author(s): Maud van Dinther, Astrid M. Hooghiemstra, Esther E. Bron, Adriaan Versteeg, Anna E. Leeuwis, Tugba Kalay, Justine E. Moonen, Sanne Kuipers, Walter H. Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie Staals, Robert J. van Oostenbrugge, Heart-Brain Connection consortium
Published in: Alzheimer's & Dementia, 2023, ISSN 1552-5279
Publisher: Alzheimer’s Association
DOI: 10.1002/alz.13408

Q-VAT: Quantitative Vascular Analysis Tool

Author(s): Bram Callewaert, Willy Gsell, Uwe Himmelreich, Elizabeth A. V. Jones
Published in: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Publisher: Frontiers In
DOI: 10.3389/fcvm.2023.1147462

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Author(s): Alastruey J, Charlton PH, Bikia V, Paliakaite B, Hametner B, Bruno RM, Mulder MP, Vennin S, Piskin S, Khir AW, Guala A, Mayer CC, Mynard J, Hughes AD, Segers P, Westerhof BE
Published in: Am J Physiol Heart Circ Physiol, Issue 325(1), 2023, Page(s) H1-H29, ISSN 0363-6135
Publisher: American Physiological Society
DOI: 10.1152/ajpheart.00705.2022

DCE-MRI reveals spatial pattern in heterogeneous blood-brain barrier leakage within white matter in cerebral small vessel disease

Author(s): Damon Verstappen, Joost J.A. de Jong, Paulien H.M Voorter, Maud van Dinther, Robert J van Oostenbrugge, Julie Staals, Jacobus F.A Jansen, Walter H Backes
Published in: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251364151

Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines

Author(s): Ramírez-Vélez R, González A, García-Hermoso A, Amézqueta IL, Izquierdo M, Díez J.
Published in: Metabolism, 2023, ISSN 1532-8600
Publisher: /
DOI: 10.1016/j.metabol.2022.155348

Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Author(s): Bennett J, van Dinther M, Voorter P, Backes W, Barnes J, Barkhof F, Captur G, Hughes AD, Sudre C, Treibel TA.
Published in: Medicina, Issue Sep 4;59(9), 2023, Page(s) 1596, ISSN 1648-9144
Publisher: MDPI
DOI: 10.3390/medicina59091596

Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement

Author(s): Jonathan Bennett, George D. Thornton, Christian Nitsche, Francisco F. Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H. Davies, James C. Moon, Thomas A. Treibel, Benjamin Adams, Shirish Ambekar, Dincer Aktuerk, Wael Awad, Andreas Baumbach, Sanjeev Bhattacharyya, Carmelo Di Salvo, Shyamsunder Kolvekar, Kulvinder Lall, David Lawrence, Miss Ana Lopez-Marco, Guy Lloyd, Simon Ke
Published in: Circulation: Cardiovascular Imaging, Issue 17, 2024, ISSN 1941-9651
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.124.017425

Editorial: Endothelial Dynamics in Health and Disease

Author(s): Elizabeth A. V. Jones, Mariona Graupera, Jaap D. van Buul, Stephan Huveneers
Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.611117

Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Author(s): González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Ben Gal T, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñ
Published in: Eur J Heart Fail, 2022, ISSN 1879-0844
Publisher: /
DOI: 10.1002/ejhf.2493

A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI

Author(s): Bram Callewaert, Willy Gsell, Marleen Lox, Uwe Himmelreich, Elizabeth A.V. Jones
Published in: Neurobiology of Disease, Issue 202, 2024, Page(s) 106709, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2024.106709

Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction

Author(s): Simmonds SJ, Grootaert MOJ, Cuijpers I, Carai P, Geuens N, Herwig M, Baatsen P, Hamdani N, Luttun A, Heymans S, Jones EAV
Published in: Eur Heart J Open, Issue Dec 9;4(1), 2023, Page(s) oead129, ISSN 2752-4191
Publisher: Oxford University Press on behalf of the European Society of Cardiology
DOI: 10.1093/ehjopen/oead129

Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Author(s): Paulien H. M. Voorter, Maud van Dinther, Willemijn J. Jansen, Alida A. Postma, Julie Staals, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Merel M. van der Thiel, Walter H. Backes
Published in: Journal of Magnetic Resonance Imaging, 2023, ISSN 1522-2586
Publisher: Wiley
DOI: 10.1002/jmri.28989

The Myocardium in Aortic Stenosis Revisited

Author(s): Patrizia Camelliti, Janos Kriston-Vizi, Rocío Eiros, George D. Thornton, Konstantinos Savvatis, Michael A. Ashworth, Begoña Lopez, Arantxa González, James C. Moon, Thomas A. Treibel
Published in: JACC: Cardiovascular Imaging, Issue 13/10, 2020, Page(s) 2270-2273, ISSN 1936-878X
Publisher: Elsevier BV
DOI: 10.1016/j.jcmg.2020.05.023

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Author(s): Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J
Published in: ACS Biomater Sci Eng, Issue Feb 12;10(2), 2024, Page(s) 987-997, ISSN 2373-9878
Publisher: ACS Publications
DOI: 10.1021/acsbiomaterials.3c01302

Time‐efficient measurement of subtle blood–brain barrier leakage using a T 1 mapping MRI protocol at 7 T

Author(s): Marieke Kerkhof, Paulien H. M. Voorter, Lisanne P. W. Canjels, Joost J. A. Jong, Robert J. Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Published in: Magnetic Resonance in Medicine, Issue 85/5, 2021, Page(s) 2761-2770, ISSN 0740-3194
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28629

The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach

Author(s): Maud van Dinther, Paulien H. M. Voorter, Eleana Zhang, Sander M. J. van Kuijk, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Walter H. Backes, Julie Staals
Published in: GeroScience, Issue 46, 2024, Page(s) 5061-5073, ISSN 2509-2723
Publisher: Springer
DOI: 10.1007/s11357-024-01235-8