MiCrovasculaR rarefaction in vascUlar Cognitive Impairement and heArt faiLure

Informazioni relative al progetto

CRUCIAL

ID dell’accordo di sovvenzione: 848109

DOI

10.3030/848109

Progetto chiuso

Data della firma CE 6 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 31 Dicembre 2024

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 6 000 000,00

Contributo UE

€ 6 000 000,00

Coordinato da

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (2)

Website and twitter account

Launch of website and twitter account

Communication Strategy

Communication Strategy - Initial strategy will be produced by the 6 month deadline. The strategy will be updated at the Periodic Reporting M18. A final communication strategy will be produced for M36.

Other (1)

Microvascular Helix

Pubblicazioni

Peer reviewed articles (37)

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Autori: Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones
Pubblicato in: Cardiovascular Diabetology, Numero 24, 2025, ISSN 1475-2840
Editore: BioMed Central
DOI: 10.1186/s12933-025-02623-w

Vessel Enlargement in Development and Pathophysiology

Autori: Laia Gifre-Renom, Elizabeth A. V. Jones
Pubblicato in: Frontiers in Physiology, Numero 12, 2021, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.639645

Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems

Autori: Kristof Van Schoor, Emmanuel Bruet, Elizabeth Anne Vincent Jones, Isabelle Migeotte
Pubblicato in: Frontiers in Physiology, Numero 15, 2024, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2024.1395006

CCR2⁺ monocyte-derived macrophages drive cardiac hypertrophy in early HFpEF

Autori: Jana Raman, Steven Simmonds, Ellen Caluwé, Rick van Leeuwen, Caroline Walschap, Mathias Stroobants, Ümare Cöl, Petra Vandervoort, Stephane Heymans, Elizabeth A. V. Jones
Pubblicato in: American Journal of Physiology-Heart and Circulatory Physiology, Numero 329, 2025, Pagina/e H109-H123, ISSN 0363-6135
Editore: American Physiological Society
DOI: 10.1152/ajpheart.00022.2025

Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure

Autori: Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z, Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal MA, Gordon DA, Ramirez-Valle F, Cappola TP
Pubblicato in: NEJM Evidence, 2022, ISSN 2766-5526
Editore: /
DOI: 10.1056/evidx2200258

Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study

Autori: van Dinther M, Schram MT, Jansen JFA, Backes WH, Houben AJHM, Berendschot TTJM, Schalkwijk CG, Stehouwer CDA, van Oostenbrugge RJ, Staals J.
Pubblicato in: Geroscience, 2022, ISSN 2509-2723
Editore: /
DOI: 10.1007/s11357-021-00493-0

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis

Autori: Ebba Brakenhielm, Arantxa González, Javier Díez
Pubblicato in: Journal of the American College of Cardiology, Numero 76/6, 2020, Pagina/e 735-744, ISSN 0735-1097
Editore: Elsevier BV
DOI: 10.1016/j.jacc.2020.05.076

Vessel architecture imaging reveals microvascular rarefaction and capillary-to-arteriole shift in cerebral small vessel disease

Autori: Paulien HM Voorter, Maud van Dinther, Gerhard S Drenthen, Elles P Elschot, Julie Staals, Robert J van Oostenbrugge, Jacobus FA Jansen, Walter H Backes, null null
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251358968

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA

Autori: Aghagolzadeh P, Plaisance I, Bernasconi R, Treibel TA, Pulido Quetglas C, Wyss T, Wigger L, Nemir M, Sarre A, Chouvardas P, Johnson R, González A, Pedrazzini T
Pubblicato in: Circulation, Numero Aug 29;148(9), 2023, Pagina/e 778-797, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.062601

Fluid flow as a driver of embryonic morphogenesis

Autori: Margo Daems, Hanna M. Peacock, Elizabeth A. V. Jones
Pubblicato in: Development, Numero 147/15, 2020, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.185579

The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model

Autori: Ilona Cuijpers, Paolo Carai, Pedro Mendes-Ferreira, Steven J. Simmonds, Paul Mulder, Daniela Miranda-Silva, Daria De Giorgio, Peter Pokreisz, Stephane Heymans, Elizabeth A. V. Jones
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-72924-5

Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging

Autori: van Dinther M, Voorter PH, Jansen JF, Jones EA, van Oostenbrugge RJ, Staals J, Backes WH
Pubblicato in: J Cereb Blood Flow Metab, 2022, ISSN 1559-7016
Editore: /
DOI: 10.1177/0271678x221076557

SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19

Autori: Daems M, Liesenborghs L, Boudewijns R, Simmonds SJ, Kraisin S, Van Wauwe J, Cuijpers I, Raman J, Geuens N, Buyten TV, Lox M, Verhamme P, Van Linthout S, Martinod K, Heymans S, Tschöpe C, Neyts J, Jones EAV
Pubblicato in: Front Cardiovasc Med, 2022, ISSN 2297-055X
Editore: /
DOI: 10.3389/fcvm.2022.964512

Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study

Autori: Marieke van den Kerkhof, Joost J.A. de Jong, Paulien H.M. Voorter, Alida A. Postma, Abraham A. Kroon, Robert J. van Oostenbrugge, Jacobus F.A. Jansen, Walter H. Backes
Pubblicato in: Hypertension, Numero 81, 2025, Pagina/e 2162-2172, ISSN 0194-911X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.22617

Management of cardiac fibrosis is the largest unmet medical need in heart failure

Autori: Javier Díez, Rudolf A de Boer
Pubblicato in: Cardiovascular Research, 2021, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvab228

Safety of ward-based, non-physician-led, cardiac monitor implantation

Autori: William T.C. Procter, Jonathan Bennett, James Elliott, Rok Mravljak, George D. Thornton, Nikoo Aziminia, Francisco Gama, Christian Nitsche, Zoe Carter, Jincymol Binoy, Christopher Monkhouse, Mark Earley, Ross J. Hunter, Thomas A. Treibel
Pubblicato in: Heart Rhythm, Numero 22, 2025, Pagina/e 271-272, ISSN 1547-5271
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2024.07.003

Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease`

Autori: Paulien H. M. Voorter, Walter H. Backes, Oliver J. Gurney-Champion, Sau-May Wong, Julie Staals, Robert J. van Oostenbrugge, Merel M. van der Thiel, Jacobus F. A. Jansen, Gerhard S. Drenthen
Pubblicato in: Magnetic Resonance in Medicine``, 2023, ISSN 1522-2594
Editore: International Society for Magnetic Resonance in Medicine
DOI: 10.1002/mrm.29753

Diffusion‐derived intravoxel‐incoherent motion anisotropy relates to CSF and blood flow

Autori: Paulien H. M. Voorter, Jacobus F. A. Jansen, Merel M. van der Thiel, Maud van Dinther, Alida A. Postma, Robert J. van Oostenbrugge, Oliver J. Gurney‐Champion, Gerhard S. Drenthen, Walter H. Backes
Pubblicato in: Magnetic Resonance in Medicine, Numero 93, 2024, Pagina/e 930-941, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.30294

Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI

Autori: van Dinther M, Voorter PHM, Schram MT, Berendschot TTJM, Houben AJHM, Webers CAB, van Oostenbrugge RJ, Backes WH, Staals J, Jansen JFA
Pubblicato in: J Neurol Sci, 2022, ISSN 0022-510X
Editore: Elsevier BV
DOI: 10.1016/j.jns.2022.120359

Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations

Autori: Bram Callewaert, Elizabeth A. V. Jones, Uwe Himmelreich, Willy Gsell
Pubblicato in: Diagnostics, Numero 11/6, 2021, Pagina/e 926, ISSN 2075-4418
Editore: /
DOI: 10.3390/diagnostics11060926

EvaluationofMicrovascularRarefactionin VascularCognitiveImpairmentandHeart Failure(CRUCIAL):StudyProtocolforan ObservationalStudy

Autori: Maud van Dinther, Jonathan Bennett, George D. Thornton, Paulien H.M. Voorter, Ana Ezponda Casajús, Alun Hughes, Gabriella Captur, Robert J. Holtackers, CRUCIAL Consortium Clinical Members, Julie Staals, Walter H. Backes, Gorka Bastarika, Elizabeth A.V. Jones, Arantxa González, Robert J. van Oostenbrugge, Thomas Alexander Treibel
Pubblicato in: Cerebrovasc Dis Extra, Numero 13(1), 2023, Pagina/e 18-32, ISSN 1664-5456
Editore: Karger
DOI: 10.1159/000529067

Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment

Autori: Maud van Dinther, Astrid M. Hooghiemstra, Esther E. Bron, Adriaan Versteeg, Anna E. Leeuwis, Tugba Kalay, Justine E. Moonen, Sanne Kuipers, Walter H. Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie Staals, Robert J. van Oostenbrugge, Heart-Brain Connection consortium
Pubblicato in: Alzheimer's & Dementia, 2023, ISSN 1552-5279
Editore: Alzheimer’s Association
DOI: 10.1002/alz.13408

Q-VAT: Quantitative Vascular Analysis Tool

Autori: Bram Callewaert, Willy Gsell, Uwe Himmelreich, Elizabeth A. V. Jones
Pubblicato in: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Editore: Frontiers In
DOI: 10.3389/fcvm.2023.1147462

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Autori: Alastruey J, Charlton PH, Bikia V, Paliakaite B, Hametner B, Bruno RM, Mulder MP, Vennin S, Piskin S, Khir AW, Guala A, Mayer CC, Mynard J, Hughes AD, Segers P, Westerhof BE
Pubblicato in: Am J Physiol Heart Circ Physiol, Numero 325(1), 2023, Pagina/e H1-H29, ISSN 0363-6135
Editore: American Physiological Society
DOI: 10.1152/ajpheart.00705.2022

DCE-MRI reveals spatial pattern in heterogeneous blood-brain barrier leakage within white matter in cerebral small vessel disease

Autori: Damon Verstappen, Joost J.A. de Jong, Paulien H.M Voorter, Maud van Dinther, Robert J van Oostenbrugge, Julie Staals, Jacobus F.A Jansen, Walter H Backes
Pubblicato in: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251364151

Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines

Autori: Ramírez-Vélez R, González A, García-Hermoso A, Amézqueta IL, Izquierdo M, Díez J.
Pubblicato in: Metabolism, 2023, ISSN 1532-8600
Editore: /
DOI: 10.1016/j.metabol.2022.155348

Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Autori: Bennett J, van Dinther M, Voorter P, Backes W, Barnes J, Barkhof F, Captur G, Hughes AD, Sudre C, Treibel TA.
Pubblicato in: Medicina, Numero Sep 4;59(9), 2023, Pagina/e 1596, ISSN 1648-9144
Editore: MDPI
DOI: 10.3390/medicina59091596

Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement

Autori: Jonathan Bennett, George D. Thornton, Christian Nitsche, Francisco F. Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H. Davies, James C. Moon, Thomas A. Treibel, Benjamin Adams, Shirish Ambekar, Dincer Aktuerk, Wael Awad, Andreas Baumbach, Sanjeev Bhattacharyya, Carmelo Di Salvo, Shyamsunder Kolvekar, Kulvinder Lall, David Lawrence, Miss Ana Lopez-Marco, Guy Lloyd, Simon Ke
Pubblicato in: Circulation: Cardiovascular Imaging, Numero 17, 2024, ISSN 1941-9651
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.124.017425

Editorial: Endothelial Dynamics in Health and Disease

Autori: Elizabeth A. V. Jones, Mariona Graupera, Jaap D. van Buul, Stephan Huveneers
Pubblicato in: Frontiers in Physiology, Numero 11, 2020, ISSN 1664-042X
Editore: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.611117

Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Autori: González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Ben Gal T, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñ
Pubblicato in: Eur J Heart Fail, 2022, ISSN 1879-0844
Editore: /
DOI: 10.1002/ejhf.2493

A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI

Autori: Bram Callewaert, Willy Gsell, Marleen Lox, Uwe Himmelreich, Elizabeth A.V. Jones
Pubblicato in: Neurobiology of Disease, Numero 202, 2024, Pagina/e 106709, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2024.106709

Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction

Autori: Simmonds SJ, Grootaert MOJ, Cuijpers I, Carai P, Geuens N, Herwig M, Baatsen P, Hamdani N, Luttun A, Heymans S, Jones EAV
Pubblicato in: Eur Heart J Open, Numero Dec 9;4(1), 2023, Pagina/e oead129, ISSN 2752-4191
Editore: Oxford University Press on behalf of the European Society of Cardiology
DOI: 10.1093/ehjopen/oead129

Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Autori: Paulien H. M. Voorter, Maud van Dinther, Willemijn J. Jansen, Alida A. Postma, Julie Staals, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Merel M. van der Thiel, Walter H. Backes
Pubblicato in: Journal of Magnetic Resonance Imaging, 2023, ISSN 1522-2586
Editore: Wiley
DOI: 10.1002/jmri.28989

The Myocardium in Aortic Stenosis Revisited

Autori: Patrizia Camelliti, Janos Kriston-Vizi, Rocío Eiros, George D. Thornton, Konstantinos Savvatis, Michael A. Ashworth, Begoña Lopez, Arantxa González, James C. Moon, Thomas A. Treibel
Pubblicato in: JACC: Cardiovascular Imaging, Numero 13/10, 2020, Pagina/e 2270-2273, ISSN 1936-878X
Editore: Elsevier BV
DOI: 10.1016/j.jcmg.2020.05.023

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Autori: Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J
Pubblicato in: ACS Biomater Sci Eng, Numero Feb 12;10(2), 2024, Pagina/e 987-997, ISSN 2373-9878
Editore: ACS Publications
DOI: 10.1021/acsbiomaterials.3c01302

Time‐efficient measurement of subtle blood–brain barrier leakage using a T 1 mapping MRI protocol at 7 T

Autori: Marieke Kerkhof, Paulien H. M. Voorter, Lisanne P. W. Canjels, Joost J. A. Jong, Robert J. Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Pubblicato in: Magnetic Resonance in Medicine, Numero 85/5, 2021, Pagina/e 2761-2770, ISSN 0740-3194
Editore: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28629

The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach

Autori: Maud van Dinther, Paulien H. M. Voorter, Eleana Zhang, Sander M. J. van Kuijk, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Walter H. Backes, Julie Staals
Pubblicato in: GeroScience, Numero 46, 2024, Pagina/e 5061-5073, ISSN 2509-2723
Editore: Springer
DOI: 10.1007/s11357-024-01235-8