MiCrovasculaR rarefaction in vascUlar Cognitive Impairement and heArt faiLure

Informacje na temat projektu

CRUCIAL

Identyfikator umowy o grant: 848109

DOI

10.3030/848109

Projekt został zamknięty

Data podpisania przez KE 6 Grudnia 2019

Data rozpoczęcia 1 Stycznia 2020

Data zakończenia 31 Grudnia 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 6 000 000,00

Wkład UE

€ 6 000 000,00

Koordynowany przez

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (2)

Website and twitter account

Launch of website and twitter account

Communication Strategy

Communication Strategy - Initial strategy will be produced by the 6 month deadline. The strategy will be updated at the Periodic Reporting M18. A final communication strategy will be produced for M36.

Other (1)

Microvascular Helix

Publikacje

Peer reviewed articles (37)

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Autorzy: Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones
Opublikowane w: Cardiovascular Diabetology, Numer 24, 2025, ISSN 1475-2840
Wydawca: BioMed Central
DOI: 10.1186/s12933-025-02623-w

Vessel Enlargement in Development and Pathophysiology

Autorzy: Laia Gifre-Renom, Elizabeth A. V. Jones
Opublikowane w: Frontiers in Physiology, Numer 12, 2021, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.639645

Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems

Autorzy: Kristof Van Schoor, Emmanuel Bruet, Elizabeth Anne Vincent Jones, Isabelle Migeotte
Opublikowane w: Frontiers in Physiology, Numer 15, 2024, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2024.1395006

CCR2⁺ monocyte-derived macrophages drive cardiac hypertrophy in early HFpEF

Autorzy: Jana Raman, Steven Simmonds, Ellen Caluwé, Rick van Leeuwen, Caroline Walschap, Mathias Stroobants, Ümare Cöl, Petra Vandervoort, Stephane Heymans, Elizabeth A. V. Jones
Opublikowane w: American Journal of Physiology-Heart and Circulatory Physiology, Numer 329, 2025, Strona(/y) H109-H123, ISSN 0363-6135
Wydawca: American Physiological Society
DOI: 10.1152/ajpheart.00022.2025

Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure

Autorzy: Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z, Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal MA, Gordon DA, Ramirez-Valle F, Cappola TP
Opublikowane w: NEJM Evidence, 2022, ISSN 2766-5526
Wydawca: /
DOI: 10.1056/evidx2200258

Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study

Autorzy: van Dinther M, Schram MT, Jansen JFA, Backes WH, Houben AJHM, Berendschot TTJM, Schalkwijk CG, Stehouwer CDA, van Oostenbrugge RJ, Staals J.
Opublikowane w: Geroscience, 2022, ISSN 2509-2723
Wydawca: /
DOI: 10.1007/s11357-021-00493-0

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis

Autorzy: Ebba Brakenhielm, Arantxa González, Javier Díez
Opublikowane w: Journal of the American College of Cardiology, Numer 76/6, 2020, Strona(/y) 735-744, ISSN 0735-1097
Wydawca: Elsevier BV
DOI: 10.1016/j.jacc.2020.05.076

Vessel architecture imaging reveals microvascular rarefaction and capillary-to-arteriole shift in cerebral small vessel disease

Autorzy: Paulien HM Voorter, Maud van Dinther, Gerhard S Drenthen, Elles P Elschot, Julie Staals, Robert J van Oostenbrugge, Jacobus FA Jansen, Walter H Backes, null null
Opublikowane w: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251358968

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA

Autorzy: Aghagolzadeh P, Plaisance I, Bernasconi R, Treibel TA, Pulido Quetglas C, Wyss T, Wigger L, Nemir M, Sarre A, Chouvardas P, Johnson R, González A, Pedrazzini T
Opublikowane w: Circulation, Numer Aug 29;148(9), 2023, Strona(/y) 778-797, ISSN 0009-7322
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.062601

Fluid flow as a driver of embryonic morphogenesis

Autorzy: Margo Daems, Hanna M. Peacock, Elizabeth A. V. Jones
Opublikowane w: Development, Numer 147/15, 2020, ISSN 0950-1991
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dev.185579

The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model

Autorzy: Ilona Cuijpers, Paolo Carai, Pedro Mendes-Ferreira, Steven J. Simmonds, Paul Mulder, Daniela Miranda-Silva, Daria De Giorgio, Peter Pokreisz, Stephane Heymans, Elizabeth A. V. Jones
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-72924-5

Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging

Autorzy: van Dinther M, Voorter PH, Jansen JF, Jones EA, van Oostenbrugge RJ, Staals J, Backes WH
Opublikowane w: J Cereb Blood Flow Metab, 2022, ISSN 1559-7016
Wydawca: /
DOI: 10.1177/0271678x221076557

SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19

Autorzy: Daems M, Liesenborghs L, Boudewijns R, Simmonds SJ, Kraisin S, Van Wauwe J, Cuijpers I, Raman J, Geuens N, Buyten TV, Lox M, Verhamme P, Van Linthout S, Martinod K, Heymans S, Tschöpe C, Neyts J, Jones EAV
Opublikowane w: Front Cardiovasc Med, 2022, ISSN 2297-055X
Wydawca: /
DOI: 10.3389/fcvm.2022.964512

Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study

Autorzy: Marieke van den Kerkhof, Joost J.A. de Jong, Paulien H.M. Voorter, Alida A. Postma, Abraham A. Kroon, Robert J. van Oostenbrugge, Jacobus F.A. Jansen, Walter H. Backes
Opublikowane w: Hypertension, Numer 81, 2025, Strona(/y) 2162-2172, ISSN 0194-911X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.22617

Management of cardiac fibrosis is the largest unmet medical need in heart failure

Autorzy: Javier Díez, Rudolf A de Boer
Opublikowane w: Cardiovascular Research, 2021, ISSN 0008-6363
Wydawca: Elsevier BV
DOI: 10.1093/cvr/cvab228

Safety of ward-based, non-physician-led, cardiac monitor implantation

Autorzy: William T.C. Procter, Jonathan Bennett, James Elliott, Rok Mravljak, George D. Thornton, Nikoo Aziminia, Francisco Gama, Christian Nitsche, Zoe Carter, Jincymol Binoy, Christopher Monkhouse, Mark Earley, Ross J. Hunter, Thomas A. Treibel
Opublikowane w: Heart Rhythm, Numer 22, 2025, Strona(/y) 271-272, ISSN 1547-5271
Wydawca: Elsevier BV
DOI: 10.1016/j.hrthm.2024.07.003

Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease`

Autorzy: Paulien H. M. Voorter, Walter H. Backes, Oliver J. Gurney-Champion, Sau-May Wong, Julie Staals, Robert J. van Oostenbrugge, Merel M. van der Thiel, Jacobus F. A. Jansen, Gerhard S. Drenthen
Opublikowane w: Magnetic Resonance in Medicine``, 2023, ISSN 1522-2594
Wydawca: International Society for Magnetic Resonance in Medicine
DOI: 10.1002/mrm.29753

Diffusion‐derived intravoxel‐incoherent motion anisotropy relates to CSF and blood flow

Autorzy: Paulien H. M. Voorter, Jacobus F. A. Jansen, Merel M. van der Thiel, Maud van Dinther, Alida A. Postma, Robert J. van Oostenbrugge, Oliver J. Gurney‐Champion, Gerhard S. Drenthen, Walter H. Backes
Opublikowane w: Magnetic Resonance in Medicine, Numer 93, 2024, Strona(/y) 930-941, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.30294

Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI

Autorzy: van Dinther M, Voorter PHM, Schram MT, Berendschot TTJM, Houben AJHM, Webers CAB, van Oostenbrugge RJ, Backes WH, Staals J, Jansen JFA
Opublikowane w: J Neurol Sci, 2022, ISSN 0022-510X
Wydawca: Elsevier BV
DOI: 10.1016/j.jns.2022.120359

Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations

Autorzy: Bram Callewaert, Elizabeth A. V. Jones, Uwe Himmelreich, Willy Gsell
Opublikowane w: Diagnostics, Numer 11/6, 2021, Strona(/y) 926, ISSN 2075-4418
Wydawca: /
DOI: 10.3390/diagnostics11060926

EvaluationofMicrovascularRarefactionin VascularCognitiveImpairmentandHeart Failure(CRUCIAL):StudyProtocolforan ObservationalStudy

Autorzy: Maud van Dinther, Jonathan Bennett, George D. Thornton, Paulien H.M. Voorter, Ana Ezponda Casajús, Alun Hughes, Gabriella Captur, Robert J. Holtackers, CRUCIAL Consortium Clinical Members, Julie Staals, Walter H. Backes, Gorka Bastarika, Elizabeth A.V. Jones, Arantxa González, Robert J. van Oostenbrugge, Thomas Alexander Treibel
Opublikowane w: Cerebrovasc Dis Extra, Numer 13(1), 2023, Strona(/y) 18-32, ISSN 1664-5456
Wydawca: Karger
DOI: 10.1159/000529067

Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment

Autorzy: Maud van Dinther, Astrid M. Hooghiemstra, Esther E. Bron, Adriaan Versteeg, Anna E. Leeuwis, Tugba Kalay, Justine E. Moonen, Sanne Kuipers, Walter H. Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie Staals, Robert J. van Oostenbrugge, Heart-Brain Connection consortium
Opublikowane w: Alzheimer's & Dementia, 2023, ISSN 1552-5279
Wydawca: Alzheimer’s Association
DOI: 10.1002/alz.13408

Q-VAT: Quantitative Vascular Analysis Tool

Autorzy: Bram Callewaert, Willy Gsell, Uwe Himmelreich, Elizabeth A. V. Jones
Opublikowane w: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Wydawca: Frontiers In
DOI: 10.3389/fcvm.2023.1147462

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Autorzy: Alastruey J, Charlton PH, Bikia V, Paliakaite B, Hametner B, Bruno RM, Mulder MP, Vennin S, Piskin S, Khir AW, Guala A, Mayer CC, Mynard J, Hughes AD, Segers P, Westerhof BE
Opublikowane w: Am J Physiol Heart Circ Physiol, Numer 325(1), 2023, Strona(/y) H1-H29, ISSN 0363-6135
Wydawca: American Physiological Society
DOI: 10.1152/ajpheart.00705.2022

DCE-MRI reveals spatial pattern in heterogeneous blood-brain barrier leakage within white matter in cerebral small vessel disease

Autorzy: Damon Verstappen, Joost J.A. de Jong, Paulien H.M Voorter, Maud van Dinther, Robert J van Oostenbrugge, Julie Staals, Jacobus F.A Jansen, Walter H Backes
Opublikowane w: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251364151

Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines

Autorzy: Ramírez-Vélez R, González A, García-Hermoso A, Amézqueta IL, Izquierdo M, Díez J.
Opublikowane w: Metabolism, 2023, ISSN 1532-8600
Wydawca: /
DOI: 10.1016/j.metabol.2022.155348

Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Autorzy: Bennett J, van Dinther M, Voorter P, Backes W, Barnes J, Barkhof F, Captur G, Hughes AD, Sudre C, Treibel TA.
Opublikowane w: Medicina, Numer Sep 4;59(9), 2023, Strona(/y) 1596, ISSN 1648-9144
Wydawca: MDPI
DOI: 10.3390/medicina59091596

Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement

Autorzy: Jonathan Bennett, George D. Thornton, Christian Nitsche, Francisco F. Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H. Davies, James C. Moon, Thomas A. Treibel, Benjamin Adams, Shirish Ambekar, Dincer Aktuerk, Wael Awad, Andreas Baumbach, Sanjeev Bhattacharyya, Carmelo Di Salvo, Shyamsunder Kolvekar, Kulvinder Lall, David Lawrence, Miss Ana Lopez-Marco, Guy Lloyd, Simon Ke
Opublikowane w: Circulation: Cardiovascular Imaging, Numer 17, 2024, ISSN 1941-9651
Wydawca: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.124.017425

Editorial: Endothelial Dynamics in Health and Disease

Autorzy: Elizabeth A. V. Jones, Mariona Graupera, Jaap D. van Buul, Stephan Huveneers
Opublikowane w: Frontiers in Physiology, Numer 11, 2020, ISSN 1664-042X
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.611117

Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Autorzy: González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Ben Gal T, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñ
Opublikowane w: Eur J Heart Fail, 2022, ISSN 1879-0844
Wydawca: /
DOI: 10.1002/ejhf.2493

A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI

Autorzy: Bram Callewaert, Willy Gsell, Marleen Lox, Uwe Himmelreich, Elizabeth A.V. Jones
Opublikowane w: Neurobiology of Disease, Numer 202, 2024, Strona(/y) 106709, ISSN 0969-9961
Wydawca: Academic Press
DOI: 10.1016/j.nbd.2024.106709

Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction

Autorzy: Simmonds SJ, Grootaert MOJ, Cuijpers I, Carai P, Geuens N, Herwig M, Baatsen P, Hamdani N, Luttun A, Heymans S, Jones EAV
Opublikowane w: Eur Heart J Open, Numer Dec 9;4(1), 2023, Strona(/y) oead129, ISSN 2752-4191
Wydawca: Oxford University Press on behalf of the European Society of Cardiology
DOI: 10.1093/ehjopen/oead129

Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Autorzy: Paulien H. M. Voorter, Maud van Dinther, Willemijn J. Jansen, Alida A. Postma, Julie Staals, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Merel M. van der Thiel, Walter H. Backes
Opublikowane w: Journal of Magnetic Resonance Imaging, 2023, ISSN 1522-2586
Wydawca: Wiley
DOI: 10.1002/jmri.28989

The Myocardium in Aortic Stenosis Revisited

Autorzy: Patrizia Camelliti, Janos Kriston-Vizi, Rocío Eiros, George D. Thornton, Konstantinos Savvatis, Michael A. Ashworth, Begoña Lopez, Arantxa González, James C. Moon, Thomas A. Treibel
Opublikowane w: JACC: Cardiovascular Imaging, Numer 13/10, 2020, Strona(/y) 2270-2273, ISSN 1936-878X
Wydawca: Elsevier BV
DOI: 10.1016/j.jcmg.2020.05.023

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Autorzy: Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J
Opublikowane w: ACS Biomater Sci Eng, Numer Feb 12;10(2), 2024, Strona(/y) 987-997, ISSN 2373-9878
Wydawca: ACS Publications
DOI: 10.1021/acsbiomaterials.3c01302

Time‐efficient measurement of subtle blood–brain barrier leakage using a T 1 mapping MRI protocol at 7 T

Autorzy: Marieke Kerkhof, Paulien H. M. Voorter, Lisanne P. W. Canjels, Joost J. A. Jong, Robert J. Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Opublikowane w: Magnetic Resonance in Medicine, Numer 85/5, 2021, Strona(/y) 2761-2770, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28629

The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach

Autorzy: Maud van Dinther, Paulien H. M. Voorter, Eleana Zhang, Sander M. J. van Kuijk, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Walter H. Backes, Julie Staals
Opublikowane w: GeroScience, Numer 46, 2024, Strona(/y) 5061-5073, ISSN 2509-2723
Wydawca: Springer
DOI: 10.1007/s11357-024-01235-8