MiCrovasculaR rarefaction in vascUlar Cognitive Impairement and heArt faiLure

Información del proyecto

CRUCIAL

Identificador del acuerdo de subvención: 848109

DOI

10.3030/848109

Proyecto cerrado

Fecha de la firma de la CE 6 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 6 000 000,00

Aportación de la UE

€ 6 000 000,00

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

Website and twitter account

Launch of website and twitter account

Communication Strategy

Communication Strategy - Initial strategy will be produced by the 6 month deadline. The strategy will be updated at the Periodic Reporting M18. A final communication strategy will be produced for M36.

Other (1)

Microvascular Helix

Publicaciones

Peer reviewed articles (37)

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Autores: Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones
Publicado en: Cardiovascular Diabetology, Edición 24, 2025, ISSN 1475-2840
Editor: BioMed Central
DOI: 10.1186/s12933-025-02623-w

Vessel Enlargement in Development and Pathophysiology

Autores: Laia Gifre-Renom, Elizabeth A. V. Jones
Publicado en: Frontiers in Physiology, Edición 12, 2021, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.639645

Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems

Autores: Kristof Van Schoor, Emmanuel Bruet, Elizabeth Anne Vincent Jones, Isabelle Migeotte
Publicado en: Frontiers in Physiology, Edición 15, 2024, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2024.1395006

CCR2⁺ monocyte-derived macrophages drive cardiac hypertrophy in early HFpEF

Autores: Jana Raman, Steven Simmonds, Ellen Caluwé, Rick van Leeuwen, Caroline Walschap, Mathias Stroobants, Ümare Cöl, Petra Vandervoort, Stephane Heymans, Elizabeth A. V. Jones
Publicado en: American Journal of Physiology-Heart and Circulatory Physiology, Edición 329, 2025, Página(s) H109-H123, ISSN 0363-6135
Editor: American Physiological Society
DOI: 10.1152/ajpheart.00022.2025

Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure

Autores: Chirinos JA, Zhao L, Reese-Petersen AL, Cohen JB, Genovese F, Richards AM, Doughty RN, Díez J, González A, Querejeta R, Zamani P, Nuñez J, Wang Z, Ebert C, Kammerhoff K, Maranville J, Basso M, Qian C, Rasmussen DGK, Schafer PH, Seiffert D, Karsdal MA, Gordon DA, Ramirez-Valle F, Cappola TP
Publicado en: NEJM Evidence, 2022, ISSN 2766-5526
Editor: /
DOI: 10.1056/evidx2200258

Extracerebral microvascular dysfunction is related to brain MRI markers of cerebral small vessel disease: The Maastricht Study

Autores: van Dinther M, Schram MT, Jansen JFA, Backes WH, Houben AJHM, Berendschot TTJM, Schalkwijk CG, Stehouwer CDA, van Oostenbrugge RJ, Staals J.
Publicado en: Geroscience, 2022, ISSN 2509-2723
Editor: /
DOI: 10.1007/s11357-021-00493-0

Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis

Autores: Ebba Brakenhielm, Arantxa González, Javier Díez
Publicado en: Journal of the American College of Cardiology, Edición 76/6, 2020, Página(s) 735-744, ISSN 0735-1097
Editor: Elsevier BV
DOI: 10.1016/j.jacc.2020.05.076

Vessel architecture imaging reveals microvascular rarefaction and capillary-to-arteriole shift in cerebral small vessel disease

Autores: Paulien HM Voorter, Maud van Dinther, Gerhard S Drenthen, Elles P Elschot, Julie Staals, Robert J van Oostenbrugge, Jacobus FA Jansen, Walter H Backes, null null
Publicado en: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251358968

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA

Autores: Aghagolzadeh P, Plaisance I, Bernasconi R, Treibel TA, Pulido Quetglas C, Wyss T, Wigger L, Nemir M, Sarre A, Chouvardas P, Johnson R, González A, Pedrazzini T
Publicado en: Circulation, Edición Aug 29;148(9), 2023, Página(s) 778-797, ISSN 0009-7322
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.122.062601

Fluid flow as a driver of embryonic morphogenesis

Autores: Margo Daems, Hanna M. Peacock, Elizabeth A. V. Jones
Publicado en: Development, Edición 147/15, 2020, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.185579

The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model

Autores: Ilona Cuijpers, Paolo Carai, Pedro Mendes-Ferreira, Steven J. Simmonds, Paul Mulder, Daniela Miranda-Silva, Daria De Giorgio, Peter Pokreisz, Stephane Heymans, Elizabeth A. V. Jones
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-72924-5

Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging

Autores: van Dinther M, Voorter PH, Jansen JF, Jones EA, van Oostenbrugge RJ, Staals J, Backes WH
Publicado en: J Cereb Blood Flow Metab, 2022, ISSN 1559-7016
Editor: /
DOI: 10.1177/0271678x221076557

SARS-CoV-2 infection causes prolonged cardiomyocyte swelling and inhibition of HIF1α translocation in an animal model COVID-19

Autores: Daems M, Liesenborghs L, Boudewijns R, Simmonds SJ, Kraisin S, Van Wauwe J, Cuijpers I, Raman J, Geuens N, Buyten TV, Lox M, Verhamme P, Van Linthout S, Martinod K, Heymans S, Tschöpe C, Neyts J, Jones EAV
Publicado en: Front Cardiovasc Med, 2022, ISSN 2297-055X
Editor: /
DOI: 10.3389/fcvm.2022.964512

Blood-Brain Barrier Integrity Decreases With Higher Blood Pressure: A 7T DCE-MRI Study

Autores: Marieke van den Kerkhof, Joost J.A. de Jong, Paulien H.M. Voorter, Alida A. Postma, Abraham A. Kroon, Robert J. van Oostenbrugge, Jacobus F.A. Jansen, Walter H. Backes
Publicado en: Hypertension, Edición 81, 2025, Página(s) 2162-2172, ISSN 0194-911X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.22617

Management of cardiac fibrosis is the largest unmet medical need in heart failure

Autores: Javier Díez, Rudolf A de Boer
Publicado en: Cardiovascular Research, 2021, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvab228

Safety of ward-based, non-physician-led, cardiac monitor implantation

Autores: William T.C. Procter, Jonathan Bennett, James Elliott, Rok Mravljak, George D. Thornton, Nikoo Aziminia, Francisco Gama, Christian Nitsche, Zoe Carter, Jincymol Binoy, Christopher Monkhouse, Mark Earley, Ross J. Hunter, Thomas A. Treibel
Publicado en: Heart Rhythm, Edición 22, 2025, Página(s) 271-272, ISSN 1547-5271
Editor: Elsevier BV
DOI: 10.1016/j.hrthm.2024.07.003

Improving microstructural integrity, interstitial fluid, and blood microcirculation images from multi-b-value diffusion MRI using physics-informed neural networks in cerebrovascular disease`

Autores: Paulien H. M. Voorter, Walter H. Backes, Oliver J. Gurney-Champion, Sau-May Wong, Julie Staals, Robert J. van Oostenbrugge, Merel M. van der Thiel, Jacobus F. A. Jansen, Gerhard S. Drenthen
Publicado en: Magnetic Resonance in Medicine``, 2023, ISSN 1522-2594
Editor: International Society for Magnetic Resonance in Medicine
DOI: 10.1002/mrm.29753

Diffusion‐derived intravoxel‐incoherent motion anisotropy relates to CSF and blood flow

Autores: Paulien H. M. Voorter, Jacobus F. A. Jansen, Merel M. van der Thiel, Maud van Dinther, Alida A. Postma, Robert J. van Oostenbrugge, Oliver J. Gurney‐Champion, Gerhard S. Drenthen, Walter H. Backes
Publicado en: Magnetic Resonance in Medicine, Edición 93, 2024, Página(s) 930-941, ISSN 0740-3194
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mrm.30294

Retinal microvascular function is associated with the cerebral microcirculation as determined by intravoxel incoherent motion MRI

Autores: van Dinther M, Voorter PHM, Schram MT, Berendschot TTJM, Houben AJHM, Webers CAB, van Oostenbrugge RJ, Backes WH, Staals J, Jansen JFA
Publicado en: J Neurol Sci, 2022, ISSN 0022-510X
Editor: Elsevier BV
DOI: 10.1016/j.jns.2022.120359

Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations

Autores: Bram Callewaert, Elizabeth A. V. Jones, Uwe Himmelreich, Willy Gsell
Publicado en: Diagnostics, Edición 11/6, 2021, Página(s) 926, ISSN 2075-4418
Editor: /
DOI: 10.3390/diagnostics11060926

EvaluationofMicrovascularRarefactionin VascularCognitiveImpairmentandHeart Failure(CRUCIAL):StudyProtocolforan ObservationalStudy

Autores: Maud van Dinther, Jonathan Bennett, George D. Thornton, Paulien H.M. Voorter, Ana Ezponda Casajús, Alun Hughes, Gabriella Captur, Robert J. Holtackers, CRUCIAL Consortium Clinical Members, Julie Staals, Walter H. Backes, Gorka Bastarika, Elizabeth A.V. Jones, Arantxa González, Robert J. van Oostenbrugge, Thomas Alexander Treibel
Publicado en: Cerebrovasc Dis Extra, Edición 13(1), 2023, Página(s) 18-32, ISSN 1664-5456
Editor: Karger
DOI: 10.1159/000529067

Lower cerebral blood flow predicts cognitive decline in patients with vascular cognitive impairment

Autores: Maud van Dinther, Astrid M. Hooghiemstra, Esther E. Bron, Adriaan Versteeg, Anna E. Leeuwis, Tugba Kalay, Justine E. Moonen, Sanne Kuipers, Walter H. Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie Staals, Robert J. van Oostenbrugge, Heart-Brain Connection consortium
Publicado en: Alzheimer's & Dementia, 2023, ISSN 1552-5279
Editor: Alzheimer’s Association
DOI: 10.1002/alz.13408

Q-VAT: Quantitative Vascular Analysis Tool

Autores: Bram Callewaert, Willy Gsell, Uwe Himmelreich, Elizabeth A. V. Jones
Publicado en: Frontiers in Cardiovascular Medicine, 2023, ISSN 2297-055X
Editor: Frontiers In
DOI: 10.3389/fcvm.2023.1147462

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Autores: Alastruey J, Charlton PH, Bikia V, Paliakaite B, Hametner B, Bruno RM, Mulder MP, Vennin S, Piskin S, Khir AW, Guala A, Mayer CC, Mynard J, Hughes AD, Segers P, Westerhof BE
Publicado en: Am J Physiol Heart Circ Physiol, Edición 325(1), 2023, Página(s) H1-H29, ISSN 0363-6135
Editor: American Physiological Society
DOI: 10.1152/ajpheart.00705.2022

DCE-MRI reveals spatial pattern in heterogeneous blood-brain barrier leakage within white matter in cerebral small vessel disease

Autores: Damon Verstappen, Joost J.A. de Jong, Paulien H.M Voorter, Maud van Dinther, Robert J van Oostenbrugge, Julie Staals, Jacobus F.A Jansen, Walter H Backes
Publicado en: Journal of Cerebral Blood Flow & Metabolism, 2025, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x251364151

Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines

Autores: Ramírez-Vélez R, González A, García-Hermoso A, Amézqueta IL, Izquierdo M, Díez J.
Publicado en: Metabolism, 2023, ISSN 1532-8600
Editor: /
DOI: 10.1016/j.metabol.2022.155348

Assessment of Microvascular Disease in Heart and Brain by MRI: Application in Heart Failure with Preserved Ejection Fraction and Cerebral Small Vessel Disease

Autores: Bennett J, van Dinther M, Voorter P, Backes W, Barnes J, Barkhof F, Captur G, Hughes AD, Sudre C, Treibel TA.
Publicado en: Medicina, Edición Sep 4;59(9), 2023, Página(s) 1596, ISSN 1648-9144
Editor: MDPI
DOI: 10.3390/medicina59091596

Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement

Autores: Jonathan Bennett, George D. Thornton, Christian Nitsche, Francisco F. Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H. Davies, James C. Moon, Thomas A. Treibel, Benjamin Adams, Shirish Ambekar, Dincer Aktuerk, Wael Awad, Andreas Baumbach, Sanjeev Bhattacharyya, Carmelo Di Salvo, Shyamsunder Kolvekar, Kulvinder Lall, David Lawrence, Miss Ana Lopez-Marco, Guy Lloyd, Simon Ke
Publicado en: Circulation: Cardiovascular Imaging, Edición 17, 2024, ISSN 1941-9651
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circimaging.124.017425

Editorial: Endothelial Dynamics in Health and Disease

Autores: Elizabeth A. V. Jones, Mariona Graupera, Jaap D. van Buul, Stephan Huveneers
Publicado en: Frontiers in Physiology, Edición 11, 2020, ISSN 1664-042X
Editor: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.611117

Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Autores: González A, Richards AM, de Boer RA, Thum T, Arfsten H, Hülsmann M, Falcao-Pires I, Díez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Ben Gal T, Cohen-Solal A, Böhm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, Núñ
Publicado en: Eur J Heart Fail, 2022, ISSN 1879-0844
Editor: /
DOI: 10.1002/ejhf.2493

A timeline study on vascular co-morbidity induced cerebral endothelial dysfunction assessed by perfusion MRI

Autores: Bram Callewaert, Willy Gsell, Marleen Lox, Uwe Himmelreich, Elizabeth A.V. Jones
Publicado en: Neurobiology of Disease, Edición 202, 2024, Página(s) 106709, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2024.106709

Pericyte loss initiates microvascular dysfunction in the development of diastolic dysfunction

Autores: Simmonds SJ, Grootaert MOJ, Cuijpers I, Carai P, Geuens N, Herwig M, Baatsen P, Hamdani N, Luttun A, Heymans S, Jones EAV
Publicado en: Eur Heart J Open, Edición Dec 9;4(1), 2023, Página(s) oead129, ISSN 2752-4191
Editor: Oxford University Press on behalf of the European Society of Cardiology
DOI: 10.1093/ehjopen/oead129

Blood–Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights

Autores: Paulien H. M. Voorter, Maud van Dinther, Willemijn J. Jansen, Alida A. Postma, Julie Staals, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Merel M. van der Thiel, Walter H. Backes
Publicado en: Journal of Magnetic Resonance Imaging, 2023, ISSN 1522-2586
Editor: Wiley
DOI: 10.1002/jmri.28989

The Myocardium in Aortic Stenosis Revisited

Autores: Patrizia Camelliti, Janos Kriston-Vizi, Rocío Eiros, George D. Thornton, Konstantinos Savvatis, Michael A. Ashworth, Begoña Lopez, Arantxa González, James C. Moon, Thomas A. Treibel
Publicado en: JACC: Cardiovascular Imaging, Edición 13/10, 2020, Página(s) 2270-2273, ISSN 1936-878X
Editor: Elsevier BV
DOI: 10.1016/j.jcmg.2020.05.023

Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays

Autores: Paz-Artigas L, González-Lana S, Polo N, Vicente P, Montero-Calle P, Martínez MA, Rábago G, Serra M, Prósper F, Mazo MM, González A, Ochoa I, Ciriza J
Publicado en: ACS Biomater Sci Eng, Edición Feb 12;10(2), 2024, Página(s) 987-997, ISSN 2373-9878
Editor: ACS Publications
DOI: 10.1021/acsbiomaterials.3c01302

Time‐efficient measurement of subtle blood–brain barrier leakage using a T 1 mapping MRI protocol at 7 T

Autores: Marieke Kerkhof, Paulien H. M. Voorter, Lisanne P. W. Canjels, Joost J. A. Jong, Robert J. Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Publicado en: Magnetic Resonance in Medicine, Edición 85/5, 2021, Página(s) 2761-2770, ISSN 0740-3194
Editor: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28629

The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach

Autores: Maud van Dinther, Paulien H. M. Voorter, Eleana Zhang, Sander M. J. van Kuijk, Jacobus F. A. Jansen, Robert J. van Oostenbrugge, Walter H. Backes, Julie Staals
Publicado en: GeroScience, Edición 46, 2024, Página(s) 5061-5073, ISSN 2509-2723
Editor: Springer
DOI: 10.1007/s11357-024-01235-8