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Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Project description

The impact of early life stress in later life

Early life stress (ELS) is a major risk factor for depression and two of its main physical comorbidities, coronary heart disease and diabetes. Some research suggests that depression develops from a complex interaction between biological and psychological processes. The EU-funded EarlyCause project will identify the biological contributions from four key interconnected domains: epigenetics, inflammation, neuroendocrine system and microbiome. It will take into account the effects of factors such as sex/gender, socioeconomics, lifestyle and behaviour. The project will combine basic, pre-clinical and clinical research, including causal inference methods, animal models of potential and postnatal stress, cellular models in various tissues, integrative bioinformatics and machine learning methods. The findings will deepen our understanding of biomarkers and innovation outputs in relation to new integrated care pathways.

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
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Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITAT DE BARCELONA
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 680 937,50

Participants (13)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 502 950
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 551 250
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 581 250
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 465 685
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 398 427,50
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 323 125
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
OULUN YLIOPISTO
Finland
EU contribution
€ 508 000
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI
Italy
EU contribution
€ 320 950
Address
Via Pilastroni 4
25125 Brescia
Activity type
Research Organisations
UNIVERSITY OF BATH
United Kingdom
EU contribution
€ 418 663,75
Address
Claverton Down
BA2 7AY Bath
Activity type
Higher or Secondary Education Establishments
STICHTING VUMC
Netherlands
EU contribution
€ 419 080
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH
Germany
EU contribution
€ 430 625
Address
Oxfordstrasse 2
53111 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
COMBINOSTICS OY
Finland
EU contribution
€ 325 500
Address
Hatanpään Valtatie 24
33100 Tampere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDAD POMPEU FABRA
Spain
EU contribution
€ 70 937,50
Address
Placa De La Merce, 10-12
08002 Barcelona
Activity type
Higher or Secondary Education Establishments