CORDIS
EU research results

CORDIS

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Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Project information

Grant agreement ID: 848158

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 5 997 381,25

  • EU contribution

    € 5 997 381,25

Coordinated by:

UNIVERSITAT DE BARCELONA

Spain

Project description

English EN

The impact of early life stress in later life

Early life stress (ELS) is a major risk factor for depression and two of its main physical comorbidities, coronary heart disease and diabetes. Some research suggests that depression develops from a complex interaction between biological and psychological processes. The EU-funded EarlyCause project will identify the biological contributions from four key interconnected domains: epigenetics, inflammation, neuroendocrine system and microbiome. It will take into account the effects of factors such as sex/gender, socioeconomics, lifestyle and behaviour. The project will combine basic, pre-clinical and clinical research, including causal inference methods, animal models of potential and postnatal stress, cellular models in various tissues, integrative bioinformatics and machine learning methods. The findings will deepen our understanding of biomarkers and innovation outputs in relation to new integrated care pathways.

Coordinator

UNIVERSITAT DE BARCELONA

Address

Gran Via De Les Corts Catalanes 585
08007 Barcelona

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 680 937,50

Participants (13)

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 502 950

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 551 250

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 581 250

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 465 685

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 398 427,50

CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

France

EU Contribution

€ 323 125

OULUN YLIOPISTO

Finland

EU Contribution

€ 508 000

PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI

Italy

EU Contribution

€ 320 950

UNIVERSITY OF BATH

United Kingdom

EU Contribution

€ 418 663,75

STICHTING VUMC

Netherlands

EU Contribution

€ 419 080

EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH

Germany

EU Contribution

€ 430 625

COMBINOSTICS OY

Finland

EU Contribution

€ 325 500

UNIVERSIDAD POMPEU FABRA

Spain

EU Contribution

€ 70 937,50

Project information

Grant agreement ID: 848158

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 5 997 381,25

  • EU contribution

    € 5 997 381,25

Coordinated by:

UNIVERSITAT DE BARCELONA

Spain