Project description
The impact of early life stress in later life
Early life stress (ELS) is a major risk factor for depression and two of its main physical comorbidities, coronary heart disease and diabetes. Some research suggests that depression develops from a complex interaction between biological and psychological processes. The EU-funded EarlyCause project will identify the biological contributions from four key interconnected domains: epigenetics, inflammation, neuroendocrine system and microbiome. It will take into account the effects of factors such as sex/gender, socioeconomics, lifestyle and behaviour. The project will combine basic, pre-clinical and clinical research, including causal inference methods, animal models of potential and postnatal stress, cellular models in various tissues, integrative bioinformatics and machine learning methods. The findings will deepen our understanding of biomarkers and innovation outputs in relation to new integrated care pathways.
Call for proposal
H2020-SC1-2019-Two-Stage-RTD
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Funding Scheme
RIA - Research and Innovation actionCoordinator
08007 Barcelona
Spain
Participants (13)
69117 Heidelberg
3015 GD Rotterdam
8006 Zurich
WC2R 2LS London
28006 Madrid
67404 Illkirch Graffenstaden
90014 Oulu
25125 Brescia
BA2 7AY Bath
1081 HV Amsterdam
53111 Bonn
33100 Tampere
08002 Barcelona
