Project description
The impact of early life stress in later life
Early life stress (ELS) is a major risk factor for depression and two of its main physical comorbidities, coronary heart disease and diabetes. Some research suggests that depression develops from a complex interaction between biological and psychological processes. The EU-funded EarlyCause project will identify the biological contributions from four key interconnected domains: epigenetics, inflammation, neuroendocrine system and microbiome. It will take into account the effects of factors such as sex/gender, socioeconomics, lifestyle and behaviour. The project will combine basic, pre-clinical and clinical research, including causal inference methods, animal models of potential and postnatal stress, cellular models in various tissues, integrative bioinformatics and machine learning methods. The findings will deepen our understanding of biomarkers and innovation outputs in relation to new integrated care pathways.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
08007 Barcelona
Spain
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Participants (13)
69117 Heidelberg
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3015 GD Rotterdam
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8006 Zurich
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WC2R 2LS London
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28006 Madrid
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67404 Illkirch Graffenstaden
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90014 Oulu
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25125 Brescia
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BA2 7AY Bath
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1081 HV Amsterdam
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53111 Bonn
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
33100 Tampere
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
08002 Barcelona
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