Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Mid-Term recruitment report

MidTerm Recruitment Report M30 Overview of recruitment by study site including numbers recruiting problems and any measures made to compensate if recruitment delays occurred

Recruitment completion review

D1.4 Recruitment Completion Review [M42]. Completion of recruitment and patient assignment for all prospective samples and patient data sent for analysis. Includes report on the status of the study registry.

Consortium Data management plan

Consortium Data Management Plan [M3]

Kick-Off meeting report

Kick-Off meeting report [M1]

Stakeholder engagement plan

Stakeholder Engagement Plan [M12] Regular plan to allow periodical discussion and assessment of DIAMONDS progress.

Annual meeting reports

Annual Meeting Reports [M13, M31, M43, M55] Reports prepared following on from each consortium meeting, focusing on progress on major deliverables and milestones.

EDTL

Establishing a European Diagnostic Transcriptomic Library [M36]. A European library of gene expression data will be created in order to provide data for the molecular taxonomy of infectious and inflammatory diseases, and subsequent generation of the PMSD.

Publications

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England

Author(s): Fabian J. S. van der Velden, Emma Lim, Lily Gills, Jasmin Broadey, Louise Hayes, Eve Roberts, Jack Courtney, Joanne Ball, Jethro Herberg, Rachel Galassini, Marieke Emonts & DIAMONDS consortium
Published in: BMC Medical Ethics, 2023, ISSN 1472-6939
Publisher: BioMed Central
DOI: 10.1186/s12910-023-00925-w

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

Author(s): Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D’Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Dani
Published in: Journal of the Pediatric Infectious Diseases Society, Issue 12, 2023, Page(s) 322-331, ISSN 2048-7207
Publisher: Oxford University Press (OUP)
DOI: 10.1093/jpids/piad035

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Author(s): Harsita Patel, Michael J. Carter, Heather Jackson, Oliver Powell, Matthew Fish, Manuela Terranova-Barberio, Filomena Spada, Nedyalko Petrov, Paul Wellman, Sarah Darnell, Sobia Mustafa, Katrina Todd, Cynthia Bishop, Jonathan M. Cohen, Julia Kenny, Sarah van den Berg, Thomas Sun, Francesca Davis, Aislinn Jennings, Emma Timms, Jessica Thomas, Maggie Nyirendra, Samuel Nichols, Leire Estamiana Elorieta
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-52246-0

The value of white blood cell count in predicting serious bacterial infections in children presenting to the emergency department: a multicentre observational study

Author(s): Naomi Kemps, Clementien Vermont, Chantal D Tan, Ulrich von Both, Enitan Carrol, Marieke Emonts, Michiel van der Flier, Jethro Adam Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Gerard Nijman, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Maria Tsolia, Dace Zavadska, Werner Zenz, Henriette A Moll, Joany M Zachariasse
Published in: Archives of Disease in Childhood, Issue 110, 2025, Page(s) 191-196, ISSN 0003-9888
Publisher: BMJ Publishing Group
DOI: 10.1136/archdischild-2024-327493

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

Author(s): Heather R Jackson, Judith Zandstra, Stephanie Menikou, Melissa Shea Hamilton, Andrew J McArdle, Roman Fischer, Adam M Thorne, Honglei Huang, Michael W Tanck, Machiel H Jansen, Tisham De, Philipp K A Agyeman, Ulrich Von Both, Enitan D Carrol, Marieke Emonts, Irini Eleftheriou, Michiel Van der Flier, Colin Fink, Jolein Gloerich, Ronald De Groot, Henriette A Moll, Marko Pokorn, Andrew J Pollard, Lure
Published in: The Lancet Digital Health, Issue 5, 2026, Page(s) e774-e785, ISSN 2589-7500
Publisher: Elsevier BV
DOI: 10.1016/s2589-7500(23)00149-8

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe

Author(s): Laura Kolberg, Aakash Khanijau, Fabian J S van der Velden, Jethro Herberg, Tisham De, Rachel Galassini, Aubrey J Cunnington, Victoria J Wright, Priyen Shah, Myrsini Kaforou, Clare Wilson, Taco Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Henriette Moll, Clementien Vermont, Marko Pokorn, Mojca Kolnik, Andrew J Pollard, Philipp K A Agyeman, Luregn J Schlapbach, Maria N Tsolia, Shunmay Ye
Published in: Clinical Infectious Diseases, Issue 78, 2024, Page(s) 526-534, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciad615

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Author(s): Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder, Chris Davis, Lily Tong, Katherine Smollett, Maria Manali, Jay Allan, Konrad Rawlik, Sarah E. McDonald, Elen Vink, Louisa Pollock, Louise Gannon, Clair Evans, Jim McMenamin, Kirsty Roy, Kimberly Marsh, Titus Divala, Matthew T. G. Holden, Michael Lockhart, David Yirrell, Sandra Currie, Maureen O’Leary, David Henderson, Sa
Published in: Nature, 2023, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05948-2

Febrile illness in high-risk children: a prospective, international observational study

Author(s): Fabian J. S. van der Velden, Gabriella de Vries, Alexander Martin, Emma Lim, Ulrich von Both, Laura Kolberg, Enitan D. Carrol, Aakash Khanijau, Jethro A. Herberg, Tisham De, Rachel Galassini, Taco W. Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Clementien L. Vermont, Nienke N. Hagedoorn, Marko Pokorn, Andrew J. Pollard, Luregn J. Schlapbach, Maria Tsolia, Irini Elefhteriou, Shunmay Yeu
Published in: European Journal of Pediatrics, Issue 182, 2023, Page(s) 543-554, ISSN 1432-1076
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00431-022-04642-1

Correction to: Group A streptococcal disease in paediatric inpatients: a European perspective

Author(s): Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan Driessen, Jan Hazelzet, Werner Zenz, Enitan D. Carrol, Suzanne T. Anderson, Federico Martinon-Torres, Philipp K. A. Agyeman, Rachel Galassini, Jethro Herberg, Michael Levin, Luregn J. Schlapbach, Marieke Emonts, null null, Michael Levin, Lachlan Coin, Stuart Gormley, Shea Hamilton, Jethro Herberg, Bernardo Hourmat, Clive Hoggart, Myrsini Kafo
Published in: European Journal of Pediatrics, Issue 182, 2023, Page(s) 707-707, ISSN 1432-1076
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00431-022-04787-z

Genomic investigations of unexplained acute hepatitis in children

Author(s): Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson, José Afonso Guerra-Assunção, Mahdi Moradi Marjaneh, Riccardo Zennezini Chiozzi, Nathaniel Storey, Luis Campos, J. Ciaran Hutchinson, John R. Counsell, Gabriele Pollara, Sunando Roy, Cristina Venturini, Juan F. Antinao Diaz, Ala’a Siam, Luke J. Tappouni, Zeinab Asgarian, Joanne Ng, Killian S. Hanlon, Alexander Len
Published in: Nature, 2023, ISSN 1476-4687
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06003-w

A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia

Author(s): Sandra Viz-Lasheras, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. P
Published in: iScience, Issue 28, 2025, Page(s) 111747, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2025.111747

Predicting trajectories of illness using RNA velocity of whole blood

Author(s): Claire Dunican, Clare Wilson, Dominic Habgood-Coote, Suzanna Paterson, Mahdad Noursadeghi, Raymond Moseki, Cari Stek, Robert J. Wilkinson, Philipp K. A. Agyeman, Coco R. Beudeker, Giske Biesbroek, Ulrich von Both, Karen Brengel-Pesce, Enitan D. Carrol, Lachlan J. M. Coin, Giselle D’Souza, Tisham De, Marieke Emonts, Katy Fidler, Colin G. Fink, Michiel van der Flier, Ioanna Georgaki, Laura Kolberg
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-026-71685-5

Group A streptococcal disease in paediatric inpatients:a European perspective

Author(s): Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan Driessen, Jan Hazelzet, Werner Zenz, Enitan D. Carrol, Suzanne T. Anderson, Federico Martinon-Torres, Philipp K. A. Agyeman, Rachel Galassini, Jethro Herberg, Michael Levin, Luregn J. Schlapbach, Marieke Emonts & EUCLIDS consortium
Published in: European Journal of Pediatrics, 2023, ISSN 1432-1076
Publisher: SpringerLink
DOI: 10.1007/s00431-022-04787-z

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

Author(s): Alexander James Martin, Fabian Johannes Stanislaus van der Velden, Ulrich von Both, Maria N Tsolia, Werner Zenz, Manfred Sagmeister, Clementien Vermont, Gabriella de Vries, Laura Kolberg, Emma Lim, Marko Pokorn, Dace Zavadska, Federico Martinón-Torres, Irene Rivero-Calle, Nienke N Hagedoorn, Effua Usuf, Luregn Schlapbach, Taco W Kuijpers, Andrew J Pollard, Shunmay Yeung, Colin Fink, Marie Voice,
Published in: Archives of Disease in Childhood, Issue 109, 2024, Page(s) 58-66, ISSN 0003-9888
Publisher: BMJ Publishing Group
DOI: 10.1136/archdischild-2023-325869

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England

Author(s): Fabian J. S. van der Velden, Emma Lim, Lily Gills, Jasmin Broadey, Louise Hayes, Eve Roberts, Jack Courtney, Joanne Ball, Jethro Herberg, Rachel Galassini, Marieke Emonts, null null, Michael Levin, Aubrey Cunnington, Myrsini Kaforou, Victoria Wright, Evangelos Bellos, Claire Broderick, Samuel Channon-Wells, Samantha Cooray, Tisham De, Giselle D’Souza, Leire Estramiana Elorrieta, Diego Estrada-Ri
Published in: BMC Medical Ethics, Issue 24, 2023, ISSN 1472-6939
Publisher: BioMed Central
DOI: 10.1186/s12910-023-00925-w

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

Author(s): Martin AJ, van der Velden FJS, von Both U on behalf of the PERFORM consortium, et al
Published in: Archives of Disease in Childhood, 2023, ISSN 0003-9888
Publisher: BMJ Publishing Group
DOI: 10.1136/archdischild2023-325869

Author(s): Laura Kolberg, Aakash Khanijau, Fabian J S van der Velden, Jethro Herberg, Tisham De, Rachel Galassini, Aubrey J Cunnington, Victoria J Wright, Priyen Shah, Myrsini Kaforou, Clare Wilson, Taco Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Henriette Moll, Clementien Vermont, Marko Pokorn, Mojca Kolnik, Andrew J Pollard, Philipp K A Agyeman, Luregn J Schlapbach, Maria N Tsolia, Shunmay Ye
Published in: Clinical Infectious Diseases, 2023, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciad615

Enhancing sepsis biomarker development: key considerations from public and private perspectives

Author(s): Jean-Francois Llitjos, Enitan D. Carrol, Marcin F. Osuchowski, Marc Bonneville, Brendon P. Scicluna, Didier Payen, Adrienne G. Randolph, Stephan Witte, Jesus Rodriguez-Manzano, Bruno François, null null
Published in: Critical Care, Issue 28, 2024, ISSN 1364-8535
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s13054-024-05032-9

Case Report: Severe Acute Pulmonary COVID-19 in a Teenager Post Autologous Hematopoietic Stem Cell Transplant

Author(s): Fabian J. S. van der Velden, Frederik van Delft, Stephen Owens, Judit Llevadias, Michael McKean, Lindsey Pulford, Yusri Taha, Grace Williamson, Quentin Campbell-Hewson, Sophie Hambleton, Rebecca Payne, Christopher Duncan, Catriona Johnston, Jarmila Spegarova, Marieke Emonts
Published in: Frontiers in Pediatrics, Issue 10, 2022, ISSN 2296-2360
Publisher: Frontiers Media SA
DOI: 10.3389/fped.2022.809061

Molecular Pathogen Testing for Identifying the Etiology of Febrile Illness in Immunocompromised Children

Author(s): Fabian JS van der Velden, Priyen Shah, Marie Voice, Emma Lim
Published in: Journal of Biotechnology and Biomedicine, Issue 06, 2023, ISSN 2642-9128
Publisher: Fortune Journals
DOI: 10.26502/jbb.2642-91280100

Biomarkers for Diagnosing Febrile Illness in Immunocompromised Children: A Systematic Review of the Literature

Author(s): Fabian J. S. van der Velden, Andrew R. Gennery, Marieke Emonts
Published in: Frontiers in Pediatrics, Issue 10, 2022, ISSN 2296-2360
Publisher: Frontiers Media SA
DOI: 10.3389/fped.2022.828569

Causes of Fever in a Cohort of Nepali Children and the Potential Impact of Molecular Testing During a Dengue Fever Outbreak

Author(s): Peter J. O’Reilly, Madhav C. Gautam, Bhishma Pokhrel, Sonu Shrestha, Meeru Gurung, Sanjeev M. Bijukchhe, Elizabeth O’Mahony, Catherine Davis, Andrew Taylor, Sarah Kelly, Ruby Basi, Anushiya Kattel, Kushal Gautam, Shriya Bista, Roshan Jha, Ram Khadka, Saugat Bhandari, Puja Amatya, Ganesh Shah, Ira Shrestha, Michael Carter, Shreekrishna Maharjan, Colin Fink, Michael Levin, Aubrey J. Cunnington,
Published in: Pediatric Infectious Disease Journal, 2026, ISSN 0891-3668
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/inf.0000000000005167

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author(s): Samuel Channon-Wells; Ortensia Vito, Andrew J McArdle, Eleanor G Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunningto
Published in: The Lancet Rheumatology, 2023, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(23)00029-2

Adoption of C-reactive protein rapid tests for the management of acute childhood infections in hospitals in the Netherlands and England: a comparative health systems analysis

Author(s): Juan Emmanuel Dewez, Ruud G. Nijman, Elizabeth J. A. Fitchett, Edmond C. Li, Queena F. Luu, Rebecca Lynch, Marieke Emonts, Ronald de Groot, Michiel van der Flier, Ria Philipsen, Stefanie Ettelt, Shunmay Yeung
Published in: BMC Health Services Research, Issue 24, 2024, ISSN 1472-6963
Publisher: BioMed Central
DOI: 10.1186/s12913-024-10698-6

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Author(s): Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder, Chris Davis, Lily Tong, Katherine Smollett, Maria Manali, Jay Allan, Konrad Rawlik, Sarah E. McDonald, Elen Vink, Louisa Pollock, Louise Gannon, Clair Evans, Jim McMenamin, Kirsty Roy, Kimberly Marsh, Titus Divala, Matthew T. G. Holden, Michael Lockhart, David Yirrell, Sandra Currie, Maureen O’Leary, David Henderson, Sa
Published in: Nature, Issue 617, 2023, Page(s) 555-563, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-05948-2

Quantifying the costs of hospital admission for families of children with a febrile illness in the North East of England

Author(s): Fabian Johannes Stanislaus van der Velden, Emma Lim, Holly Smith, Rebecca Walsh, Marieke Emonts
Published in: BMJ Paediatrics Open, Issue 8, 2025, Page(s) e002489, ISSN 2399-9772
Publisher: BMJ
DOI: 10.1136/bmjpo-2023-002489

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

Author(s): Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D’Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Dani
Published in: Journal of the Pediatric Infectious Diseases Society, 2023, ISSN 2048-7207
Publisher: University of Chicago Press
DOI: 10.1093/jpids/piad035

A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment

Author(s): Sandra Viz-Lasheras, Alberto Gómez-Carballa, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Nina Schweintzger, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. P
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-55932-9

Treatment of Multisystem Inflammatory Syndrome in Children

Author(s): Andrew J. McArdle, Ortensia Vito, Harsita Patel, Eleanor G. Seaby, Priyen Shah, Clare Wilson, Claire Broderick, Ruud Nijman, Adriana H. Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Michael Levin
Published in: New England Journal of Medicine, Issue 385, 2025, Page(s) 11-22, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmoa2102968

Priorities for the development of a new rapid diagnostic test for patients with fever: a cross-sectional online survey among hospital physicians across Europe

Author(s): Gabrielle Bonnet, Maryke Joanne Nielsen, Anna M Foss, Alex Lewin, Ruud Gerard Nijman, Elizabeth Fitchett, Enitan Carrol, Shunmay Yeung
Published in: BMJ Open, Issue 16, 2026, Page(s) e107663, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2025-107663

Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases

Author(s): Sophya Yeoh, Diego Estrada-Rivadeneyra, Heather Jackson, Ilana Keren, Rachel Galassini, Samantha Cooray, Priyen Shah, Philipp Agyeman, Romain Basmaci, Enitan Carrol, Marieke Emonts, Colin Fink, Taco Kuijpers, Federico Martinon-Torres, Marine Mommert-Tripon, Stephane Paulus, Marko Pokorn, Pablo Rojo, Lorenza Romani, Luregn Schlapbach, Nina Schweintzger, Ching-Fen Shen, Maria Tsolia, Effua Usuf, Mic
Published in: Pediatric Infectious Disease Journal, Issue 43, 2025, Page(s) 444-453, ISSN 0891-3668
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/inf.0000000000004267

Immunity to <i>Streptococcus pyogenes</i> and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions

Author(s): Kitt Dokal, Samuel Channon-Wells, Catherine Davis, Diego Estrada-Rivadeneyra, Kristin K. Huse, Amelia Lias, Shea Hamilton, Rebecca L. Guy, Theresa Lamagni, Sam Nichols, Andrew Taylor, Philipp K. A. Agyeman, Amutha Anpananthar, Romain Basmaci, Enitan D. Carrol, Michael J. Carter, Tisham De, Marien I. de Jonge, Marieke Emonts, Leire Estramiana Elorrieta, Katy Fidler, Mojca Kolnik, Taco W. Kuijpers,
Published in: JAMA Network Open, Issue 8, 2025, Page(s) e2537808, ISSN 2574-3805
Publisher: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2025.37808

Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases

Genomic investigations of unexplained acute hepatitis in children

Author(s): Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson, José Afonso Guerra-Assunção, Mahdi Moradi Marjaneh, Riccardo Zennezini Chiozzi, Nathaniel Storey, Luis Campos, J. Ciaran Hutchinson, John R. Counsell, Gabriele Pollara, Sunando Roy, Cristina Venturini, Juan F. Antinao Diaz, Ala’a Siam, Luke J. Tappouni, Zeinab Asgarian, Joanne Ng, Killian S. Hanlon, Alexander Len
Published in: Nature, Issue 617, 2023, Page(s) 564-573, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06003-w

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author(s): Samuel Channon-Wells, Ortensia Vito, Andrew J McArdle, Eleanor G Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunningto
Published in: The Lancet Rheumatology, Issue 5, 2025, Page(s) e184-e199, ISSN 2665-9913
Publisher: Elsevier BV
DOI: 10.1016/s2665-9913(23)00029-2

Which low urgent triaged febrile children are suitable for a fast track? An observational European study

Author(s): Chantal D Tan, Clementien L Vermont, Joany M Zachariasse, Ulrich von Both, Enitan D Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K Maconochie, Federico Martinon-Torres, Ruud G Nijman, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Maria Tsolia, Werner Zenz, Dace Zavadska, Henriette A Moll
Published in: Emergency Medicine Journal, Issue 41, 2025, Page(s) 236-241, ISSN 1472-0205
Publisher: BMJ Publishing Group
DOI: 10.1136/emermed-2023-213375

Quantifying the costs of hospital admission for families of children with a febrile illness in the North East of England

Molecular Pathogen Testing for Identifying the Etiology of Febrile Illness in Immunocompromised Children

Author(s): Fabian JS van der Velden, Priyen Shah, Marie Voice, Emma Lim, Jethro Herberg, Victoria Wright3, Tisham De, Enitan D. Carrol, Aakash Khanijau, Andrew J Pollard, Stéphane Paulus, Ulrich von Both8, Laura Kolberg, Clementien L Vermont, Nienke N Hagedoorn, Federico Martinón-Torres, Irene Rivero Calle, Philipp KA Agyeman, Luregn J Schlapbach, Maria Tsolia, Irini Eleftheriou, Marko Pokorn, Mojca Kolnik
Published in: Journal of Biotechnology and Biomedicine, 2023, ISSN 2642-9128
Publisher: Fortune Journals
DOI: 10.26502/jbb.2642-91280100

Enhancing sepsis biomarker development: key considerations from public and private perspectives

Procalcitonin use in febrile children attending European emergency departments: a prospective multicenter study

Author(s): Dorine M. Borensztajn, Joany M. Zachariasse, Enitan D. Carrol, Ruud G. Nijman, Ulrich von Both, Marieke Emonts, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K. Maconochie, Federico Martinón-Torres, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Chantal D. Tan, Maria Tsolia, Clementien Vermont, Dace Zavadska, Werner Zenz, Henriette A. Moll, null null, Nienke N. Hagedoorn,
Published in: BMC Pediatrics, Issue 25, 2025, ISSN 1471-2431
Publisher: BioMed Central
DOI: 10.1186/s12887-025-05483-1

Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Author(s): Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. N
Published in: Journal of Experimental Medicine, Issue 221, 2024, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20240699

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

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