Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis

Projektinformationen

DIAMONDS

ID Finanzhilfevereinbarung: 848196

DOI

10.3030/848196

Projekt abgeschlossen

EK-Unterschriftsdatum 6 Dezember 2019

Startdatum 1 Januar 2020

Enddatum 31 März 2026

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 23 816 918,75

EU-Beitrag

€ 22 582 021,13

Koordiniert durch

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (6)

Mid-Term recruitment report

MidTerm Recruitment Report M30 Overview of recruitment by study site including numbers recruiting problems and any measures made to compensate if recruitment delays occurred

Recruitment completion review

D1.4 Recruitment Completion Review [M42]. Completion of recruitment and patient assignment for all prospective samples and patient data sent for analysis. Includes report on the status of the study registry.

Consortium Data management plan

Consortium Data Management Plan [M3]

Kick-Off meeting report

Kick-Off meeting report [M1]

Stakeholder engagement plan

Stakeholder Engagement Plan [M12] Regular plan to allow periodical discussion and assessment of DIAMONDS progress.

Annual meeting reports

Annual Meeting Reports [M13, M31, M43, M55] Reports prepared following on from each consortium meeting, focusing on progress on major deliverables and milestones.

Open Research Data Pilot (1)

EDTL

Establishing a European Diagnostic Transcriptomic Library [M36]. A European library of gene expression data will be created in order to provide data for the molecular taxonomy of infectious and inflammatory diseases, and subsequent generation of the PMSD.

Websites, patent fillings, videos etc. (1)

Project website

Project Website [M4] Website will be developed at the earliest stage possible, maintained throughout the duration of the project, in collaboration with WP2.

Veröffentlichungen

Peer reviewed articles (42)

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England

Autoren: Fabian J. S. van der Velden, Emma Lim, Lily Gills, Jasmin Broadey, Louise Hayes, Eve Roberts, Jack Courtney, Joanne Ball, Jethro Herberg, Rachel Galassini, Marieke Emonts & DIAMONDS consortium
Veröffentlicht in: BMC Medical Ethics, 2023, ISSN 1472-6939
Herausgeber: BioMed Central
DOI: 10.1186/s12910-023-00925-w

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

Autoren: Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D’Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Dani
Veröffentlicht in: Journal of the Pediatric Infectious Diseases Society, Ausgabe 12, 2023, Seite(n) 322-331, ISSN 2048-7207
Herausgeber: Oxford University Press (OUP)
DOI: 10.1093/jpids/piad035

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Autoren: Harsita Patel, Michael J. Carter, Heather Jackson, Oliver Powell, Matthew Fish, Manuela Terranova-Barberio, Filomena Spada, Nedyalko Petrov, Paul Wellman, Sarah Darnell, Sobia Mustafa, Katrina Todd, Cynthia Bishop, Jonathan M. Cohen, Julia Kenny, Sarah van den Berg, Thomas Sun, Francesca Davis, Aislinn Jennings, Emma Timms, Jessica Thomas, Maggie Nyirendra, Samuel Nichols, Leire Estamiana Elorieta
Veröffentlicht in: Nature Communications, Ausgabe 15, 2024, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-024-52246-0

The value of white blood cell count in predicting serious bacterial infections in children presenting to the emergency department: a multicentre observational study

Autoren: Naomi Kemps, Clementien Vermont, Chantal D Tan, Ulrich von Both, Enitan Carrol, Marieke Emonts, Michiel van der Flier, Jethro Adam Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Gerard Nijman, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Maria Tsolia, Dace Zavadska, Werner Zenz, Henriette A Moll, Joany M Zachariasse
Veröffentlicht in: Archives of Disease in Childhood, Ausgabe 110, 2025, Seite(n) 191-196, ISSN 0003-9888
Herausgeber: BMJ Publishing Group
DOI: 10.1136/archdischild-2024-327493

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

Autoren: Heather R Jackson, Judith Zandstra, Stephanie Menikou, Melissa Shea Hamilton, Andrew J McArdle, Roman Fischer, Adam M Thorne, Honglei Huang, Michael W Tanck, Machiel H Jansen, Tisham De, Philipp K A Agyeman, Ulrich Von Both, Enitan D Carrol, Marieke Emonts, Irini Eleftheriou, Michiel Van der Flier, Colin Fink, Jolein Gloerich, Ronald De Groot, Henriette A Moll, Marko Pokorn, Andrew J Pollard, Lure
Veröffentlicht in: The Lancet Digital Health, Ausgabe 5, 2026, Seite(n) e774-e785, ISSN 2589-7500
Herausgeber: Elsevier BV
DOI: 10.1016/s2589-7500(23)00149-8

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe

Autoren: Laura Kolberg, Aakash Khanijau, Fabian J S van der Velden, Jethro Herberg, Tisham De, Rachel Galassini, Aubrey J Cunnington, Victoria J Wright, Priyen Shah, Myrsini Kaforou, Clare Wilson, Taco Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Henriette Moll, Clementien Vermont, Marko Pokorn, Mojca Kolnik, Andrew J Pollard, Philipp K A Agyeman, Luregn J Schlapbach, Maria N Tsolia, Shunmay Ye
Veröffentlicht in: Clinical Infectious Diseases, Ausgabe 78, 2024, Seite(n) 526-534, ISSN 1058-4838
Herausgeber: University of Chicago Press
DOI: 10.1093/cid/ciad615

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Autoren: Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder, Chris Davis, Lily Tong, Katherine Smollett, Maria Manali, Jay Allan, Konrad Rawlik, Sarah E. McDonald, Elen Vink, Louisa Pollock, Louise Gannon, Clair Evans, Jim McMenamin, Kirsty Roy, Kimberly Marsh, Titus Divala, Matthew T. G. Holden, Michael Lockhart, David Yirrell, Sandra Currie, Maureen O’Leary, David Henderson, Sa
Veröffentlicht in: Nature, 2023, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-023-05948-2

Febrile illness in high-risk children: a prospective, international observational study

Autoren: Fabian J. S. van der Velden, Gabriella de Vries, Alexander Martin, Emma Lim, Ulrich von Both, Laura Kolberg, Enitan D. Carrol, Aakash Khanijau, Jethro A. Herberg, Tisham De, Rachel Galassini, Taco W. Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Clementien L. Vermont, Nienke N. Hagedoorn, Marko Pokorn, Andrew J. Pollard, Luregn J. Schlapbach, Maria Tsolia, Irini Elefhteriou, Shunmay Yeu
Veröffentlicht in: European Journal of Pediatrics, Ausgabe 182, 2023, Seite(n) 543-554, ISSN 1432-1076
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/s00431-022-04642-1

Correction to: Group A streptococcal disease in paediatric inpatients: a European perspective

Autoren: Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan Driessen, Jan Hazelzet, Werner Zenz, Enitan D. Carrol, Suzanne T. Anderson, Federico Martinon-Torres, Philipp K. A. Agyeman, Rachel Galassini, Jethro Herberg, Michael Levin, Luregn J. Schlapbach, Marieke Emonts, null null, Michael Levin, Lachlan Coin, Stuart Gormley, Shea Hamilton, Jethro Herberg, Bernardo Hourmat, Clive Hoggart, Myrsini Kafo
Veröffentlicht in: European Journal of Pediatrics, Ausgabe 182, 2023, Seite(n) 707-707, ISSN 1432-1076
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/s00431-022-04787-z

Genomic investigations of unexplained acute hepatitis in children

Autoren: Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson, José Afonso Guerra-Assunção, Mahdi Moradi Marjaneh, Riccardo Zennezini Chiozzi, Nathaniel Storey, Luis Campos, J. Ciaran Hutchinson, John R. Counsell, Gabriele Pollara, Sunando Roy, Cristina Venturini, Juan F. Antinao Diaz, Ala’a Siam, Luke J. Tappouni, Zeinab Asgarian, Joanne Ng, Killian S. Hanlon, Alexander Len
Veröffentlicht in: Nature, 2023, ISSN 1476-4687
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-023-06003-w

A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia

Autoren: Sandra Viz-Lasheras, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. P
Veröffentlicht in: iScience, Ausgabe 28, 2025, Seite(n) 111747, ISSN 2589-0042
Herausgeber: Elsevier BV
DOI: 10.1016/j.isci.2025.111747

Predicting trajectories of illness using RNA velocity of whole blood

Autoren: Claire Dunican, Clare Wilson, Dominic Habgood-Coote, Suzanna Paterson, Mahdad Noursadeghi, Raymond Moseki, Cari Stek, Robert J. Wilkinson, Philipp K. A. Agyeman, Coco R. Beudeker, Giske Biesbroek, Ulrich von Both, Karen Brengel-Pesce, Enitan D. Carrol, Lachlan J. M. Coin, Giselle D’Souza, Tisham De, Marieke Emonts, Katy Fidler, Colin G. Fink, Michiel van der Flier, Ioanna Georgaki, Laura Kolberg
Veröffentlicht in: Nature Communications, Ausgabe 17, 2026, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-026-71685-5

Group A streptococcal disease in paediatric inpatients:a European perspective

Autoren: Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan Driessen, Jan Hazelzet, Werner Zenz, Enitan D. Carrol, Suzanne T. Anderson, Federico Martinon-Torres, Philipp K. A. Agyeman, Rachel Galassini, Jethro Herberg, Michael Levin, Luregn J. Schlapbach, Marieke Emonts & EUCLIDS consortium
Veröffentlicht in: European Journal of Pediatrics, 2023, ISSN 1432-1076
Herausgeber: SpringerLink
DOI: 10.1007/s00431-022-04787-z

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

Autoren: Alexander James Martin, Fabian Johannes Stanislaus van der Velden, Ulrich von Both, Maria N Tsolia, Werner Zenz, Manfred Sagmeister, Clementien Vermont, Gabriella de Vries, Laura Kolberg, Emma Lim, Marko Pokorn, Dace Zavadska, Federico Martinón-Torres, Irene Rivero-Calle, Nienke N Hagedoorn, Effua Usuf, Luregn Schlapbach, Taco W Kuijpers, Andrew J Pollard, Shunmay Yeung, Colin Fink, Marie Voice,
Veröffentlicht in: Archives of Disease in Childhood, Ausgabe 109, 2024, Seite(n) 58-66, ISSN 0003-9888
Herausgeber: BMJ Publishing Group
DOI: 10.1136/archdischild-2023-325869

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England

Autoren: Fabian J. S. van der Velden, Emma Lim, Lily Gills, Jasmin Broadey, Louise Hayes, Eve Roberts, Jack Courtney, Joanne Ball, Jethro Herberg, Rachel Galassini, Marieke Emonts, null null, Michael Levin, Aubrey Cunnington, Myrsini Kaforou, Victoria Wright, Evangelos Bellos, Claire Broderick, Samuel Channon-Wells, Samantha Cooray, Tisham De, Giselle D’Souza, Leire Estramiana Elorrieta, Diego Estrada-Ri
Veröffentlicht in: BMC Medical Ethics, Ausgabe 24, 2023, ISSN 1472-6939
Herausgeber: BioMed Central
DOI: 10.1186/s12910-023-00925-w

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

Autoren: Martin AJ, van der Velden FJS, von Both U on behalf of the PERFORM consortium, et al
Veröffentlicht in: Archives of Disease in Childhood, 2023, ISSN 0003-9888
Herausgeber: BMJ Publishing Group
DOI: 10.1136/archdischild2023-325869

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe

Autoren: Laura Kolberg, Aakash Khanijau, Fabian J S van der Velden, Jethro Herberg, Tisham De, Rachel Galassini, Aubrey J Cunnington, Victoria J Wright, Priyen Shah, Myrsini Kaforou, Clare Wilson, Taco Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Henriette Moll, Clementien Vermont, Marko Pokorn, Mojca Kolnik, Andrew J Pollard, Philipp K A Agyeman, Luregn J Schlapbach, Maria N Tsolia, Shunmay Ye
Veröffentlicht in: Clinical Infectious Diseases, 2023, ISSN 1058-4838
Herausgeber: University of Chicago Press
DOI: 10.1093/cid/ciad615

Enhancing sepsis biomarker development: key considerations from public and private perspectives

Autoren: Jean-Francois Llitjos, Enitan D. Carrol, Marcin F. Osuchowski, Marc Bonneville, Brendon P. Scicluna, Didier Payen, Adrienne G. Randolph, Stephan Witte, Jesus Rodriguez-Manzano, Bruno François, null null
Veröffentlicht in: Critical Care, Ausgabe 28, 2024, ISSN 1364-8535
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/s13054-024-05032-9

Case Report: Severe Acute Pulmonary COVID-19 in a Teenager Post Autologous Hematopoietic Stem Cell Transplant

Autoren: Fabian J. S. van der Velden, Frederik van Delft, Stephen Owens, Judit Llevadias, Michael McKean, Lindsey Pulford, Yusri Taha, Grace Williamson, Quentin Campbell-Hewson, Sophie Hambleton, Rebecca Payne, Christopher Duncan, Catriona Johnston, Jarmila Spegarova, Marieke Emonts
Veröffentlicht in: Frontiers in Pediatrics, Ausgabe 10, 2022, ISSN 2296-2360
Herausgeber: Frontiers Media SA
DOI: 10.3389/fped.2022.809061

Molecular Pathogen Testing for Identifying the Etiology of Febrile Illness in Immunocompromised Children

Autoren: Fabian JS van der Velden, Priyen Shah, Marie Voice, Emma Lim
Veröffentlicht in: Journal of Biotechnology and Biomedicine, Ausgabe 06, 2023, ISSN 2642-9128
Herausgeber: Fortune Journals
DOI: 10.26502/jbb.2642-91280100

Biomarkers for Diagnosing Febrile Illness in Immunocompromised Children: A Systematic Review of the Literature

Autoren: Fabian J. S. van der Velden, Andrew R. Gennery, Marieke Emonts
Veröffentlicht in: Frontiers in Pediatrics, Ausgabe 10, 2022, ISSN 2296-2360
Herausgeber: Frontiers Media SA
DOI: 10.3389/fped.2022.828569

Causes of Fever in a Cohort of Nepali Children and the Potential Impact of Molecular Testing During a Dengue Fever Outbreak

Autoren: Peter J. O’Reilly, Madhav C. Gautam, Bhishma Pokhrel, Sonu Shrestha, Meeru Gurung, Sanjeev M. Bijukchhe, Elizabeth O’Mahony, Catherine Davis, Andrew Taylor, Sarah Kelly, Ruby Basi, Anushiya Kattel, Kushal Gautam, Shriya Bista, Roshan Jha, Ram Khadka, Saugat Bhandari, Puja Amatya, Ganesh Shah, Ira Shrestha, Michael Carter, Shreekrishna Maharjan, Colin Fink, Michael Levin, Aubrey J. Cunnington,
Veröffentlicht in: Pediatric Infectious Disease Journal, 2026, ISSN 0891-3668
Herausgeber: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/inf.0000000000005167

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Autoren: Samuel Channon-Wells; Ortensia Vito, Andrew J McArdle, Eleanor G Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunningto
Veröffentlicht in: The Lancet Rheumatology, 2023, ISSN 2665-9913
Herausgeber: Elsevier
DOI: 10.1016/s2665-9913(23)00029-2

Adoption of C-reactive protein rapid tests for the management of acute childhood infections in hospitals in the Netherlands and England: a comparative health systems analysis

Autoren: Juan Emmanuel Dewez, Ruud G. Nijman, Elizabeth J. A. Fitchett, Edmond C. Li, Queena F. Luu, Rebecca Lynch, Marieke Emonts, Ronald de Groot, Michiel van der Flier, Ria Philipsen, Stefanie Ettelt, Shunmay Yeung
Veröffentlicht in: BMC Health Services Research, Ausgabe 24, 2024, ISSN 1472-6963
Herausgeber: BioMed Central
DOI: 10.1186/s12913-024-10698-6

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Autoren: Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder, Chris Davis, Lily Tong, Katherine Smollett, Maria Manali, Jay Allan, Konrad Rawlik, Sarah E. McDonald, Elen Vink, Louisa Pollock, Louise Gannon, Clair Evans, Jim McMenamin, Kirsty Roy, Kimberly Marsh, Titus Divala, Matthew T. G. Holden, Michael Lockhart, David Yirrell, Sandra Currie, Maureen O’Leary, David Henderson, Sa
Veröffentlicht in: Nature, Ausgabe 617, 2023, Seite(n) 555-563, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-023-05948-2

Quantifying the costs of hospital admission for families of children with a febrile illness in the North East of England

Autoren: Fabian Johannes Stanislaus van der Velden, Emma Lim, Holly Smith, Rebecca Walsh, Marieke Emonts
Veröffentlicht in: BMJ Paediatrics Open, Ausgabe 8, 2025, Seite(n) e002489, ISSN 2399-9772
Herausgeber: BMJ
DOI: 10.1136/bmjpo-2023-002489

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

Autoren: Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D’Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Dani
Veröffentlicht in: Journal of the Pediatric Infectious Diseases Society, 2023, ISSN 2048-7207
Herausgeber: University of Chicago Press
DOI: 10.1093/jpids/piad035

A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment

Autoren: Sandra Viz-Lasheras, Alberto Gómez-Carballa, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Nina Schweintzger, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. P
Veröffentlicht in: Nature Communications, Ausgabe 16, 2025, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-025-55932-9

Treatment of Multisystem Inflammatory Syndrome in Children

Autoren: Andrew J. McArdle, Ortensia Vito, Harsita Patel, Eleanor G. Seaby, Priyen Shah, Clare Wilson, Claire Broderick, Ruud Nijman, Adriana H. Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Michael Levin
Veröffentlicht in: New England Journal of Medicine, Ausgabe 385, 2025, Seite(n) 11-22, ISSN 0028-4793
Herausgeber: Massachusetts Medical Society
DOI: 10.1056/nejmoa2102968

Priorities for the development of a new rapid diagnostic test for patients with fever: a cross-sectional online survey among hospital physicians across Europe

Autoren: Gabrielle Bonnet, Maryke Joanne Nielsen, Anna M Foss, Alex Lewin, Ruud Gerard Nijman, Elizabeth Fitchett, Enitan Carrol, Shunmay Yeung
Veröffentlicht in: BMJ Open, Ausgabe 16, 2026, Seite(n) e107663, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmjopen-2025-107663

Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases

Autoren: Sophya Yeoh, Diego Estrada-Rivadeneyra, Heather Jackson, Ilana Keren, Rachel Galassini, Samantha Cooray, Priyen Shah, Philipp Agyeman, Romain Basmaci, Enitan Carrol, Marieke Emonts, Colin Fink, Taco Kuijpers, Federico Martinon-Torres, Marine Mommert-Tripon, Stephane Paulus, Marko Pokorn, Pablo Rojo, Lorenza Romani, Luregn Schlapbach, Nina Schweintzger, Ching-Fen Shen, Maria Tsolia, Effua Usuf, Mic
Veröffentlicht in: Pediatric Infectious Disease Journal, Ausgabe 43, 2025, Seite(n) 444-453, ISSN 0891-3668
Herausgeber: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/inf.0000000000004267

Immunity to <i>Streptococcus pyogenes</i> and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions

Autoren: Kitt Dokal, Samuel Channon-Wells, Catherine Davis, Diego Estrada-Rivadeneyra, Kristin K. Huse, Amelia Lias, Shea Hamilton, Rebecca L. Guy, Theresa Lamagni, Sam Nichols, Andrew Taylor, Philipp K. A. Agyeman, Amutha Anpananthar, Romain Basmaci, Enitan D. Carrol, Michael J. Carter, Tisham De, Marien I. de Jonge, Marieke Emonts, Leire Estramiana Elorrieta, Katy Fidler, Mojca Kolnik, Taco W. Kuijpers,
Veröffentlicht in: JAMA Network Open, Ausgabe 8, 2025, Seite(n) e2537808, ISSN 2574-3805
Herausgeber: American Medical Association (AMA)
DOI: 10.1001/jamanetworkopen.2025.37808

Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases

Autoren: Sophya Yeoh, Diego Estrada-Rivadeneyra, Heather Jackson, Ilana Keren, Rachel Galassini, Samantha Cooray, Priyen Shah, Philipp Agyeman, Romain Basmaci, Enitan Carrol, Marieke Emonts, Colin Fink, Taco Kuijpers, Federico Martinon-Torres, Marine Mommert-Tripon, Stephane Paulus, Marko Pokorn, Pablo Rojo, Lorenza Romani, Luregn Schlapbach, Nina Schweintzger, Ching-Fen Shen, Maria Tsolia, Effua Usuf, Mic
Veröffentlicht in: Pediatric Infectious Disease Journal, Ausgabe 43, 2025, Seite(n) 444-453, ISSN 0891-3668
Herausgeber: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/inf.0000000000004267

Genomic investigations of unexplained acute hepatitis in children

Autoren: Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson, José Afonso Guerra-Assunção, Mahdi Moradi Marjaneh, Riccardo Zennezini Chiozzi, Nathaniel Storey, Luis Campos, J. Ciaran Hutchinson, John R. Counsell, Gabriele Pollara, Sunando Roy, Cristina Venturini, Juan F. Antinao Diaz, Ala’a Siam, Luke J. Tappouni, Zeinab Asgarian, Joanne Ng, Killian S. Hanlon, Alexander Len
Veröffentlicht in: Nature, Ausgabe 617, 2023, Seite(n) 564-573, ISSN 0028-0836
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41586-023-06003-w

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Autoren: Samuel Channon-Wells, Ortensia Vito, Andrew J McArdle, Eleanor G Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunningto
Veröffentlicht in: The Lancet Rheumatology, Ausgabe 5, 2025, Seite(n) e184-e199, ISSN 2665-9913
Herausgeber: Elsevier BV
DOI: 10.1016/s2665-9913(23)00029-2

Which low urgent triaged febrile children are suitable for a fast track? An observational European study

Autoren: Chantal D Tan, Clementien L Vermont, Joany M Zachariasse, Ulrich von Both, Enitan D Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K Maconochie, Federico Martinon-Torres, Ruud G Nijman, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Maria Tsolia, Werner Zenz, Dace Zavadska, Henriette A Moll
Veröffentlicht in: Emergency Medicine Journal, Ausgabe 41, 2025, Seite(n) 236-241, ISSN 1472-0205
Herausgeber: BMJ Publishing Group
DOI: 10.1136/emermed-2023-213375

Quantifying the costs of hospital admission for families of children with a febrile illness in the North East of England

Autoren: Fabian Johannes Stanislaus van der Velden, Emma Lim, Holly Smith, Rebecca Walsh, Marieke Emonts
Veröffentlicht in: BMJ Paediatrics Open, Ausgabe 8, 2025, Seite(n) e002489, ISSN 2399-9772
Herausgeber: BMJ
DOI: 10.1136/bmjpo-2023-002489

Molecular Pathogen Testing for Identifying the Etiology of Febrile Illness in Immunocompromised Children

Autoren: Fabian JS van der Velden, Priyen Shah, Marie Voice, Emma Lim, Jethro Herberg, Victoria Wright3, Tisham De, Enitan D. Carrol, Aakash Khanijau, Andrew J Pollard, Stéphane Paulus, Ulrich von Both8, Laura Kolberg, Clementien L Vermont, Nienke N Hagedoorn, Federico Martinón-Torres, Irene Rivero Calle, Philipp KA Agyeman, Luregn J Schlapbach, Maria Tsolia, Irini Eleftheriou, Marko Pokorn, Mojca Kolnik
Veröffentlicht in: Journal of Biotechnology and Biomedicine, 2023, ISSN 2642-9128
Herausgeber: Fortune Journals
DOI: 10.26502/jbb.2642-91280100

Enhancing sepsis biomarker development: key considerations from public and private perspectives

Autoren: Jean-Francois Llitjos, Enitan D. Carrol, Marcin F. Osuchowski, Marc Bonneville, Brendon P. Scicluna, Didier Payen, Adrienne G. Randolph, Stephan Witte, Jesus Rodriguez-Manzano, Bruno François, null null
Veröffentlicht in: Critical Care, Ausgabe 28, 2024, ISSN 1364-8535
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/s13054-024-05032-9

Procalcitonin use in febrile children attending European emergency departments: a prospective multicenter study

Autoren: Dorine M. Borensztajn, Joany M. Zachariasse, Enitan D. Carrol, Ruud G. Nijman, Ulrich von Both, Marieke Emonts, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K. Maconochie, Federico Martinón-Torres, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Chantal D. Tan, Maria Tsolia, Clementien Vermont, Dace Zavadska, Werner Zenz, Henriette A. Moll, null null, Nienke N. Hagedoorn,
Veröffentlicht in: BMC Pediatrics, Ausgabe 25, 2025, ISSN 1471-2431
Herausgeber: BioMed Central
DOI: 10.1186/s12887-025-05483-1

Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Autoren: Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. N
Veröffentlicht in: Journal of Experimental Medicine, Ausgabe 221, 2024, ISSN 0022-1007
Herausgeber: Rockefeller University Press
DOI: 10.1084/jem.20240699

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Autoren: Harsita Patel, Michael J. Carter, Heather Jackson, Oliver Powell, Matthew Fish, Manuela Terranova-Barberio, Filomena Spada, Nedyalko Petrov, Paul Wellman, Sarah Darnell, Sobia Mustafa, Katrina Todd, Cynthia Bishop, Jonathan M. Cohen, Julia Kenny, Sarah van den Berg, Thomas Sun, Francesca Davis, Aislinn Jennings, Emma Timms, Jessica Thomas, Maggie Nyirendra, Samuel Nichols, Leire Estamiana Elorieta
Veröffentlicht in: Nature Communications, Ausgabe 15, 2024, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-024-52246-0