Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis

Livrables

MidTerm Recruitment Report M30 Overview of recruitment by study site including numbers recruiting problems and any measures made to compensate if recruitment delays occurred

Consortium Data management plan

Consortium Data Management Plan [M3]

Kick-Off meeting report

Kick-Off meeting report [M1]

Stakeholder engagement plan

Stakeholder Engagement Plan [M12] Regular plan to allow periodical discussion and assessment of DIAMONDS progress.

Annual meeting reports

Annual Meeting Reports [M13, M31, M43, M55] Reports prepared following on from each consortium meeting, focusing on progress on major deliverables and milestones.

EDTL

Establishing a European Diagnostic Transcriptomic Library [M36]. A European library of gene expression data will be created in order to provide data for the molecular taxonomy of infectious and inflammatory diseases, and subsequent generation of the PMSD.

Project website

Project Website [M4] Website will be developed at the earliest stage possible, maintained throughout the duration of the project, in collaboration with WP2.

Publications

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England

Auteurs: Fabian J. S. van der Velden, Emma Lim, Lily Gills, Jasmin Broadey, Louise Hayes, Eve Roberts, Jack Courtney, Joanne Ball, Jethro Herberg, Rachel Galassini, Marieke Emonts & DIAMONDS consortium
Publié dans: BMC Medical Ethics, 2023, ISSN 1472-6939
Éditeur: BioMed Central
DOI: 10.1186/s12910-023-00925-w

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Auteurs: Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder, Chris Davis, Lily Tong, Katherine Smollett, Maria Manali, Jay Allan, Konrad Rawlik, Sarah E. McDonald, Elen Vink, Louisa Pollock, Louise Gannon, Clair Evans, Jim McMenamin, Kirsty Roy, Kimberly Marsh, Titus Divala, Matthew T. G. Holden, Michael Lockhart, David Yirrell, Sandra Currie, Maureen O’Leary, David Henderson, Sa
Publié dans: Nature, 2023, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-023-05948-2

Genomic investigations of unexplained acute hepatitis in children

Auteurs: Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson, José Afonso Guerra-Assunção, Mahdi Moradi Marjaneh, Riccardo Zennezini Chiozzi, Nathaniel Storey, Luis Campos, J. Ciaran Hutchinson, John R. Counsell, Gabriele Pollara, Sunando Roy, Cristina Venturini, Juan F. Antinao Diaz, Ala’a Siam, Luke J. Tappouni, Zeinab Asgarian, Joanne Ng, Killian S. Hanlon, Alexander Len
Publié dans: Nature, 2023, ISSN 1476-4687
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-023-06003-w

Group A streptococcal disease in paediatric inpatients:a European perspective

Auteurs: Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan Driessen, Jan Hazelzet, Werner Zenz, Enitan D. Carrol, Suzanne T. Anderson, Federico Martinon-Torres, Philipp K. A. Agyeman, Rachel Galassini, Jethro Herberg, Michael Levin, Luregn J. Schlapbach, Marieke Emonts & EUCLIDS consortium
Publié dans: European Journal of Pediatrics, 2023, ISSN 1432-1076
Éditeur: SpringerLink
DOI: 10.1007/s00431-022-04787-z

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

Auteurs: Martin AJ, van der Velden FJS, von Both U on behalf of the PERFORM consortium, et al
Publié dans: Archives of Disease in Childhood, 2023, ISSN 0003-9888
Éditeur: BMJ Publishing Group
DOI: 10.1136/archdischild2023-325869

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe

Auteurs: Laura Kolberg, Aakash Khanijau, Fabian J S van der Velden, Jethro Herberg, Tisham De, Rachel Galassini, Aubrey J Cunnington, Victoria J Wright, Priyen Shah, Myrsini Kaforou, Clare Wilson, Taco Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Henriette Moll, Clementien Vermont, Marko Pokorn, Mojca Kolnik, Andrew J Pollard, Philipp K A Agyeman, Luregn J Schlapbach, Maria N Tsolia, Shunmay Ye
Publié dans: Clinical Infectious Diseases, 2023, ISSN 1058-4838
Éditeur: University of Chicago Press
DOI: 10.1093/cid/ciad615

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Auteurs: Samuel Channon-Wells; Ortensia Vito, Andrew J McArdle, Eleanor G Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunningto
Publié dans: The Lancet Rheumatology, 2023, ISSN 2665-9913
Éditeur: Elsevier
DOI: 10.1016/s2665-9913(23)00029-2

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

Auteurs: Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D’Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Dani
Publié dans: Journal of the Pediatric Infectious Diseases Society, 2023, ISSN 2048-7207
Éditeur: University of Chicago Press
DOI: 10.1093/jpids/piad035

Molecular Pathogen Testing for Identifying the Etiology of Febrile Illness in Immunocompromised Children

Auteurs: Fabian JS van der Velden, Priyen Shah, Marie Voice, Emma Lim, Jethro Herberg, Victoria Wright3, Tisham De, Enitan D. Carrol, Aakash Khanijau, Andrew J Pollard, Stéphane Paulus, Ulrich von Both8, Laura Kolberg, Clementien L Vermont, Nienke N Hagedoorn, Federico Martinón-Torres, Irene Rivero Calle, Philipp KA Agyeman, Luregn J Schlapbach, Maria Tsolia, Irini Eleftheriou, Marko Pokorn, Mojca Kolnik
Publié dans: Journal of Biotechnology and Biomedicine, 2023, ISSN 2642-9128
Éditeur: Fortune Journals
DOI: 10.26502/jbb.2642-91280100

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