THERVACB: A THERAPEUTIC VACCINE TO CURE HEPATITIS B

Livrables

Synopsis and protocol of the patient registry

In close cooperation with all WP partners MHH will provide a short protocol as well as the study synopsis of the patient registry.

Cross-network SOPs for immunoassays

SOPs for centralized and decentralized immunoassays available and in place; initial cross-validation of decentralized immunoassays to ensure inter-lab precision finished

Agreement of sample storage

HMGU will provide an informed consent form and an SOPs for sample preparation and storage (plasma and PBMCs) for all participating centers

Incidental Findings Policy

Report on the Incidental Findings Policy

THERVACB web site and the relevant social media

Overview of the objectives of the THERVACB public website as part of the dissemination strategy, and its main functionalities, as well as an outline of the THERVACB social media strategy.

Publications

PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B

Auteurs: Till Bunse, Anna D Kosinska, Thomas Michler, Ulrike Protzer
Publié dans: Biomolecules, Numéro 12(3):470, 2022, ISSN 2218-273X
Éditeur: MDPI Open Access Journals
DOI: 10.3390/biom12030470

Practical Benefits, Challenges, and Recommendations on Social Media Recruitment: Multi-Stakeholder Interview Study

Auteurs: Goldman N, Willem T, Buyx A, Zimmermann B
Publié dans: Journal of Medical Internet Research, Numéro 25:e44587, 2023, ISSN 1438-8871
Éditeur: Journal of medical Internet Research
DOI: 10.2196/44587

Social media advertising for clinical studies: Ethical and data protection implications of online targeting

Auteurs: Rainer Mühlhoff, Theresa Willem
Publié dans: Big Data & Society, Numéro 10 (1), 2023, ISSN 2053-9517
Éditeur: SAGE
DOI: 10.1177/205395172311561

Ethical Issues in Social Media Recruitment for Clinical Studies: Ethical Analysis and Framework

Auteurs: Zimmermann BM, Willem T, Bredthauer CJ, Buyx A
Publié dans: J Med Internet Res, Numéro 24 (5), 2022, ISSN 1438-8871
Éditeur: Journal of medical Internet Research
DOI: 10.2196/31231

Correction: Ethical Issues in Social Media Recruitment for Clinical Studies: Ethical Analysis and Framework

Auteurs: Bettina M Zimmermann; Theresa Willem; Carl Justus Bredthauer; Alena Buyx
Publié dans: J Med Internet Res, 2022, ISSN 1438-8871
Éditeur: Journal of medical Internet Research
DOI: 10.2196/40848

Immunogenicity and Antiviral Response of Therapeutic Hepatitis B Vaccination in a Mouse Model of HBeAg-Negative, Persistent HBV Infection

Auteurs: Kosinska, A.D.; Festag, J.; Mück-Häusl, M.; Festag, M.M.; Asen, T.; Protzer, U.
Publié dans: Vaccines, Numéro 9(8), 841, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9080841

Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models

Auteurs: Jinpeng Su, Livia Brunner, Edanur Ates Oz, Julia Sacherl, Geraldine Frank, Helene Anne Kerth, Frank Thiele, Marian Wiegand, Carolin Mogler, Julio Cesar Aguilar, Percy A. Knolle, Nicolas Collin, Anna D. Kosinska, Ulrike Protzer
Publié dans: Journal of Hepatology, 2023, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/j.jhep.2022.12.013

Evaluation of the Effect of CD70 Co-Expression on CD8 T Cell Response in Protein-Prime MVA-Boost Vaccination in Mice

Auteurs: Ann-Sophie Stephan; Anna D. Kosinska; Martin Mück-Häusl; Andreas Muschaweckh; Clemens Jäger; Natalie Röder; Mathias Heikenwälder; Claudia Dembek; Ulrike Protzer
Publié dans: Volume 11, Numéro 1, 2023, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11020245

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