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Deciphering the cellular origin and evolution of malignant rhabdoid tumors

Project description

Understanding the origin and progression of rhabdoid tumours

Malignant rhabdoid tumour is a highly aggressive, paediatric soft-tissue cancer with a low survival rate. It presents in various tissues including brain and kidney, and probably originates from aberrant differentiation during development. Understanding the origin and relationships of rhabdoid tumours is crucial for discovering new treatment options. The EU-funded RhabdoEvo project aims to identify the cellular origin of rhabdoid tumours and the molecular mechanisms driving disease progression and chemotherapy resistance. Having developed rhabdoid tumour organoid culture from patient tissue, researchers will apply single-cell epigenomic and transcriptomic analyses for characterisation of cellular identity and heterogeneity within tumours. Using genetic lineage-tracing technology to process the data obtained will help to uncover clonal dynamics in rhabdoid tumour progression and therapy resistance.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/colorectal cancer

Call for proposal

ERC-2019-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Address
Heidelberglaan 25
3584CS Utrecht
Netherlands
Activity type
Other
EU contribution
€ 1 500 000

Beneficiaries (1)

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
EU contribution
€ 1 500 000
Address
Heidelberglaan 25
3584CS Utrecht
Activity type
Other