Deciphering the cellular origin and evolution of malignant rhabdoid tumors

Project Information

RhabdoEvo

Grant agreement ID: 850571

DOI

10.3030/850571

Project closed

EC signature date 26 November 2019

Start date 1 December 2019

End date 31 May 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Open Research Data Pilot

Publications

Peer reviewed articles (15)

Organoid models of childhood kidney tumours

Author(s): Ariadne H. A. G. Ooms, Camilla Calandrini, Ronald R. de Krijger, Jarno Drost
Published in: Nature Reviews Urology, Issue 17, 2023, Page(s) 311-313, ISSN 1759-4812
Publisher: Nature Publishing Group
DOI: 10.1038/s41585-020-0315-y

In vitro Modeling of Embryonal Tumors

Author(s): Lars Custers, Irene Paassen, Jarno Drost
Published in: Frontiers in Cell and Developmental Biology, Issue February 2021 | Volume 9 | Article 640633, 2021, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2021.640633

Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities

Author(s): Camilla Calandrini, Jarno Drost
Published in: STAR Protocols, Issue Volume 3, Issue 1, 18 March 2022, 2022, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.101079

Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

Author(s): Irene Paassen, Justin Williams, Carla Ríos Arceo, Femke Ringnalda, Kimberly Shea Mercer, Juliane L. Buhl, Natalia Moreno, Aniello Federico, Niels E. Franke, Mariette Kranendonk, Santhosh A. Upadhyaya, Kornelius Kerl, Marc van de Wetering, Hans Clevers, Marcel Kool, Eelco W. Hoving, Martine F. Roussel, Jarno Drost
Published in: Oncogene, Issue 42, 2023, Page(s) 1661-1671, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-023-02681-y

Generation of Human Kidney Tubuloids from Tissue and Urine

Author(s): Camilla Calandrini, Jarno Drost
Published in: The Journal of Visualized Experiments, 2021, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62404

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma

Author(s): Jeff DeMartino, Michael T. Meister, Lindy L. Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Amber K. L. Wezenaar, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Anne C. Rios, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38886-8

Single cell derived mRNA signals across human kidney tumors

Author(s): Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H.
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23949-5

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying SFPQ-TFE3 driven translocation RCC

Author(s): Maroussia M.P. Ganpat, Francisco Morales-Rodriguez, Nhung Pham, Philip Lijnzaad, Terezinha de Souza, Sepide Derakhshan, Arianna Fumagalli, Peter Zeller, Aleksandra Balwierz, Dilara Ayyildiz, Marry M. van den Heuvel-Eibrink, Ronald R. de Krijger, Alexander van Oudenaarden, Thanasis Margaritis, Susana M. Chuva de Sousa Lopes, Jarno Drost
Published in: iScience, Issue 28, 2025, Page(s) 112122, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2025.112122

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Author(s): Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21675-6

Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

Author(s): Camilla Calandrini, Sander R. van Hooff, Irene Paassen, Dilara Ayyildiz, Sepide Derakhshan, M. Emmy M. Dolman, Karin P.S. Langenberg, Marieke van de Ven, Cecilia de Heus, Nalan Liv, Marcel Kool, Ronald R. de Krijger, Godelieve A.M. Tytgat, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Jarno Drost
Published in: Cell Reports, Issue AUGUST 24, 2021, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109568

Bridging the gap: advancing cancer cell culture to reveal key metabolic targets

Author(s): Marjolein M. G. Kes, Celia R. Berkers, Jarno Drost
Published in: Frontiers in Oncology, Issue 14, 2024, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2024.1480613

Integration of multiple lineage measurements from the same cell reconstructs parallel tumor evolution

Author(s): Lennart Kester, Buys de Barbanson, Anna Lyubimova, Li-Ting Chen, Valérie van der Schrier, Anna Alemany, Dylan Mooijman, Josi Peterson-Maduro, Jarno Drost, Jeroen de Ridder, Alexander van Oudenaarden
Published in: Cell Genomics, 2022, ISSN 2666-979X
Publisher: CellPress
DOI: 10.1016/j.xgen.2022.100096

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

Author(s): Meister, M.T., Groot Koerkamp, M.J.A., de Souza, T., Breunis, W.B., Frazer-Mendelewska, E., Brok, M., DeMartino, J., Manders, F., Calandrini, C., Kerstens, H.H.D., Janse, A., Dolman, M.E.M., Eising, S., Langenberg, K.P.S., van Tuil, M., Knops, R.R.G., van Scheltinga, S.T., Hiemcke-Jiwa, L.S., Flucke, U., Merks, J.H.M., van Noesel, M.M., Tops, B.B.J., Hehir-Kwa, J.Y., Kemmeren, P., Molenaar, J.J.,
Published in: EMBO Molecular Medicine, 2022, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202216001

SMARCB1 loss activates patient-specific distal oncogenic enhancers in malignant rhabdoid tumors.

Author(s): Ning Qing Liu, Irene Paassen, Lars Custers, Peter Zeller, Hans Teunissen, Dilara Ayyildiz, Jiayou He, Juliane Laura Buhl, Eelco Wieger Hoving, Alexander van Oudenaarden, Elzo de Wit, Jarno Drost.
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43498-3

High resolution clonal architecture of hypomutated Wilms tumours

Author(s): Henry Lee-Six, Taryn D. Treger, Manas Dave, Tim HH Coorens, Nathaniel D. Anderson, Yvonne Tiersma, Sepide Derakhshan, Sanne de Haan, Marry M. van den Heuvel-Eibrink, Yichen Wang, Anna Wenger, Reem Al-Saadi, Alice Lawford, Aleksandra Letunovska, Jenny Wegert, Conor Parks, Guillaume Morcrette, Manfred Gessler, Gordan Vujanic, Tanzina Chowdhury, Maureen J O’Sullivan, Ronald R. de Krijger, Michael R
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-59854-4