Understanding the impact of nanoplastics on the development of neurological disorders

Información del proyecto

NanoGlia

Identificador del acuerdo de subvención: 851257

DOI

10.3030/851257

Proyecto cerrado

Fecha de la firma de la CE 23 Enero 2020

Fecha de inicio 1 Abril 2020

Fecha de finalización 31 Marzo 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 497 193,00

Aportación de la UE

€ 1 497 193,00

Coordinado por

RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Publicaciones

Peer reviewed articles (17)

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue

Autores: Katharina Sieckmann, Nora Winnerling, Dalila Juliana Silva Ribeiro, Seniz Yüksel, Ronja Kardinal, Lisa Maria Steinheuer, Fabian Frechen, Luis Henrique Corrêa, Geza Schermann, Christina Klausen, Nelli Blank-Stein, Jonas Schulte-Schrepping, Collins Osei-Sarpong, Matthias Becker, Lorenzo Bonaguro, Marc Beyer, Helen Louise May-Simera, Jelena Zurkovic, Christoph Thiele, Kevin Thurley, Lydia Sorokin,
Publicado en: The EMBO Journal, Edición 44, 2026, Página(s) 5315-5336, ISSN 1460-2075
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44318-025-00524-y

Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism

Autores: Nikola Makdissi, Maria Francesca Viola, Lisa Maria Steinheuer, Nelli Blank-Stein, Ronja Kardinal, Fabrizio Musacchio, Eliana Franco Taveras, Virginia Aliprandi, Katharina Sieckmann, Akram Abdulkadyrov, Marina L. Mayer, Marie-Louise Diefenbach-Wilke, Diana Fink, Hannes Beckert, Stefan Böhmdorfer, Quentin Deveuve, Frederike J. Graelmann, Katharina Mauel, Nele Kronau, Jake Thomas, David Bejarano, An
Publicado en: Nature Metabolism, 2026, ISSN 2522-5812
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42255-026-01615-8

Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner

Autores: Seyhmus Bayar, Lea Seep, Karolína Doubková, Jelena Zurkovic, Margret H. Bülow, Katrin Kierdorf, Reinhard Bauer, Christoph Thiele, Gaia Tavosanis, Jan Hasenauer, Elvira Mass
Publicado en: Cells & Development, Edición 183, 2026, Página(s) 204040, ISSN 2667-2901
Editor: Elsevier BV
DOI: 10.1016/j.cdev.2025.204040

Emerging principles of primary cilia dynamics in controlling tissue organization and function

Autores: Jay Gopalakrishnan, Kerstin Feistel, Benjamin M Friedrich, Anne Grapin‐Botton, Nathalie Jurisch‐Yaksi, Elvira Mass, David U Mick, Roman‐Ulrich Müller, Helen May‐Simera, Bernhard Schermer, Miriam Schmidts, Peter Walentek, Dagmar Wachten
Publicado en: The EMBO Journal, Edición 42, 2026, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.2023113891

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Autores: Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Mel
Publicado en: Nature Cell Biology, Edición 23, 2023, Página(s) 1224-1239, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-021-00774-y

CD163+ red pulp macrophages interact with marginal metallophilic macrophages during blood-stage malaria to maintain splenic architecture

Autores: Katharina Mauel, Daria Hirschmann, Nelli Blank-Stein, Marie-Louise Diefenbach-Wilke, Theresa Eulgem, Shirley Le, Samuel N. Breit, Miguel P. Soares, Vicky Wang-Wei Tsai, Florent Ginhoux, William R. Heath, Lynette Beattie, Elvira Mass
Publicado en: Immunity, 2026, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2026.07.006

From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists

Autores: Lea Seep, Stephan Grein, Iva Splichalova, Danli Ran, Mickel Mikhael, Staffan Hildebrand, Mario Lauterbach, Karsten Hiller, Dalila Juliana Silva Ribeiro, Katharina Sieckmann, Ronja Kardinal, Hao Huang, Jiangyan Yu, Sebastian Kallabis, Janina Behrens, Andreas Till, Viktoriya Peeva, Akim Strohmeyer, Johanna Bruder, Tobias Blum, Ana Soriano-Arroquia, Dominik Tischer, Katharina Kuellmer, Yuanfang Li, M
Publicado en: Scientific Data, Edición 11, 2026, ISSN 2052-4463
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41597-024-03349-2

Tissue-specific macrophages: how they develop and choreograph tissue biology

Autores: Elvira Mass, Falk Nimmerjahn, Katrin Kierdorf & Andreas Schlitzer
Publicado en: Nature Reviews Immunology, 2023, ISSN 1474-1733
Editor: Nature Publishing Group
DOI: 10.1038/s41577-023-00848-y

Kupffer cell programming by maternal obesity triggers fatty liver disease

Autores: Hao Huang, Nora R. Balzer, Lea Seep, Iva Splichalova, Nelli Blank-Stein, Maria Francesca Viola, Eliana Franco Taveras, Kerim Acil, Diana Fink, Franzisca Petrovic, Nikola Makdissi, Seyhmus Bayar, Katharina Mauel, Carolin Radwaniak, Jelena Zurkovic, Amir H. Kayvanjoo, Klaus Wunderling, Malin Jessen, Mohamed H. Yaghmour, Lukas Kenner, Thomas Ulas, Stephan Grein, Joachim L. Schultze, Charlotte L. Scot
Publicado en: Nature, Edición 644, 2025, Página(s) 790-798, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-025-09190-w

Macrophage and monocyte subsets in response to ischemic stroke

Autores: Nelli Blank‐Stein, Elvira Mass
Publicado en: European Journal of Immunology, Edición 53, 2024, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202250233

Kupffer cells control neonatal hepatic metabolism via Igf1 signaling

Autores: Nikola Makdissi, Daria J. Hirschmann, Aleksej Frolov, Inaam Sado, Bastian Bennühr, Fabian Nikolka, Jingyuan Cheng, Nelli Blank-Stein, Maria Francesca Viola, Mohamed Yaghmour, Philipp Arnold, Lorenzo Bonaguro, Matthias Becker, Christoph Thiele, Felix Meissner, Karsten Hiller, Marc D. Beyer, Elvira Mass
Publicado en: Development, Edición 153, 2026, ISSN 0950-1991
Editor: The Company of Biologists Ltd.
DOI: 10.1242/dev.204962

Differential impact of high-salt levels in vitro and in vivo on macrophage core functions

Autores: Linda Müller, Aya Rafea Nasr, Bettina Jux, Nikola Makdissi, Justin Wayne Trowbridge, Susanne V. Schmidt, Joachim L. Schultze, Thomas Quast, Jonas Schulte-Schrepping, Waldemar Kolanus, Elvira Mass
Publicado en: Molecular Biology Reports, Edición 343, 2024, Página(s) Volume 51, Edición 1, ISSN 1573-4978
Editor: Springer Nature
DOI: 10.21203/rs.3.rs-3768163/v1

Renal tissue-resident macrophages promote cystogenesis in early polycystic kidney disease

Autores: Rudolfo Karl, Arsila Palliyulla Kariat Ashraf, Maria Francesca Viola, Katharina Hopp, Elvira Mass, Dagmar Wachten
Publicado en: Journal of Cell Science, Edición 138, 2025, ISSN 0021-9533
Editor: The Company of Biologists Ltd.
DOI: 10.1242/jcs.263992

From macrophage biology to macrophage-based cellular immunotherapies

Autores: Elvira Mass, Nico Lachmann
Publicado en: Gene Therapy, Edición 28/9, 2021, Página(s) 473-476, ISSN 0969-7128
Editor: Nature Publishing Group
DOI: 10.1038/s41434-021-00221-5

Validation and refinement of existing methods for timed mating and early pregnancy detection in guinea pigs

Autores: Marina Luisa Mayer, Ilja Finkelberg, Elvira Mass
Publicado en: PLOS One, Edición 21, 2026, Página(s) e0347318, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0347318

Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

Autores: Aleksej Frolov, Hao Huang, Dagmar Schütz, Maren Köhne, Nelli Blank-Stein, Collins Osei-Sarpong, Maren Büttner, Tarek Elmzzahi, Mukhran Khundadze, Marina Zahid, Michael Reuter, Matthias Becker, Elena De Domenico, Lorenzo Bonaguro, Axel Kallies, Helen Morrison, Christian A. Hübner, Kristian Händler, Ralf Stumm, Elvira Mass, Marc D. Beyer
Publicado en: Journal of Experimental Medicine, Edición 222, 2025, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20232357

Developmental programming of tissue-resident macrophages

Autores: Maria Francesca Viola, Eliana Franco Taveras, Elvira Mass
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1475369

Non-peer reviewed articles (1)

How much plastic is too much for our brain?

Autores: Elvira Mass
Publicado en: The Project Repository journal, Edición 6, 2020, Página(s) 8–11, ISSN 2632-4067
Editor: European Dissemination Media Agency

Book chapters (4)

Ontogeny and function of microglia and nerve-associated macrophages

Autores: Marina Mayer, Eliana Franco Taveras, Elvira Mass
Publicado en: Advances in Immunology, 2025, Página(s) 91-122
Editor: Elsevier
DOI: 10.1016/bs.ai.2025.04.002

The development and physiological and pathophysiological functions of resident macrophages and glial cells

Autores: Nelli Blank, Marina Mayer, Elvira Mass
Publicado en: Advances in Immunology volume 151, Edición 151, 2021, Página(s) 1-47, ISBN 9780128245996
Editor: Elsevier
DOI: 10.1016/bs.ai.2021.08.001

Fate-Mapping of Yolk Sac-Derived Macrophages

Autores: Iva Splichalova, Elvira Mass
Publicado en: Methods in Molecular Biology, Tissue-Resident Macrophages, 2023, Página(s) 129-137
Editor: Springer US
DOI: 10.1007/978-1-0716-3437-0_8

Fate-Mapping of Hematopoietic Stem Cell-Derived Macrophages

Autores: Katharina Mauel, Elvira Mass
Publicado en: Methods in Molecular Biology, Tissue-Resident Macrophages, 2023, Página(s) 139-148
Editor: Springer US
DOI: 10.1007/978-1-0716-3437-0_9

Conference proceedings (1)

THE IMPACT OF PLASTIC POLLUTION ON HUMAN NEURODEVELOPMENT AND NEUROINFLAMMATION

Autores: Nelli Blank-Stein, Marina L. Mayer, Maria Francesca Viola, Elvira Mass
Publicado en: GLIA (Meeting Abstract Supplement), Edición Volume 73, Supplement S1, 26. Juni 2025, 2025, Página(s) 852, ISSN 0894-1491
Editor: John Wiley & Sons, Inc.

Other (1)

Our plastic world – what does it mean for our health?

Autores: Marina Mayer, Nikola Makdissi, Maria Francesca Viola, Elvira Mass
Publicado en: The Project Repository Journal (PRj), Edición Volume 19, November 2023, 2023, ISSN 2632-4113
Editor: European Dissemination Media Agency (EDMA)